ID G1SHL5_RABIT Unreviewed; 4965 AA.
AC G1SHL5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSOCUP00000002126.3};
GN Name=RYR2 {ECO:0000313|Ensembl:ENSOCUP00000002126.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000002126.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000002126.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000002126.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000002126.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000002126.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Ca(2+)(in) = Ca(2+)(out); Xref=Rhea:RHEA:29671,
CC ChEBI:CHEBI:29108; Evidence={ECO:0000256|ARBA:ARBA00036634};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Sarcoplasmic
CC reticulum membrane {ECO:0000256|ARBA:ARBA00004326}; Multi-pass membrane
CC protein {ECO:0000256|ARBA:ARBA00004326}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAGW02026444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02026453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR Ensembl; ENSOCUT00000002456.3; ENSOCUP00000002126.3; ENSOCUG00000002425.3.
DR GeneTree; ENSGT00940000154906; -.
DR InParanoid; G1SHL5; -.
DR Proteomes; UP000001811; Chromosome 16.
DR Bgee; ENSOCUG00000002425; Expressed in heart and 9 other cell types or tissues.
DR ExpressionAtlas; G1SHL5; baseline.
DR GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
DR GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
DR GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR GO; GO:0043924; F:suramin binding; IEA:Ensembl.
DR GO; GO:0060402; P:calcium ion transport into cytosol; IEA:Ensembl.
DR GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR GO; GO:0003300; P:cardiac muscle hypertrophy; IEA:Ensembl.
DR GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR GO; GO:0071872; P:cellular response to epinephrine stimulus; IEA:Ensembl.
DR GO; GO:0005513; P:detection of calcium ion; IEA:Ensembl.
DR GO; GO:0003143; P:embryonic heart tube morphogenesis; IEA:Ensembl.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0072599; P:establishment of protein localization to endoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR GO; GO:0051284; P:positive regulation of sequestering of calcium ion; IEA:Ensembl.
DR GO; GO:0098735; P:positive regulation of the force of heart contraction; IEA:Ensembl.
DR GO; GO:0086029; P:Purkinje myocyte to ventricular cardiac muscle cell signaling; IEA:Ensembl.
DR GO; GO:0098910; P:regulation of atrial cardiac muscle cell action potential; IEA:Ensembl.
DR GO; GO:0098904; P:regulation of AV node cell action potential; IEA:Ensembl.
DR GO; GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Ensembl.
DR GO; GO:0098907; P:regulation of SA node cell action potential; IEA:Ensembl.
DR GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR GO; GO:0014850; P:response to muscle activity; IEA:Ensembl.
DR GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
DR GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR GO; GO:0097050; P:type B pancreatic cell apoptotic process; IEA:Ensembl.
DR GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR CDD; cd12877; SPRY1_RyR; 1.
DR CDD; cd12878; SPRY2_RyR; 1.
DR CDD; cd12879; SPRY3_RyR; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.490.160; -; 3.
DR Gene3D; 2.60.120.920; -; 3.
DR Gene3D; 2.80.10.50; -; 2.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR013333; Ryan_recept.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR003032; Ryanodine_rcpt.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR InterPro; IPR048581; RYDR_Jsol.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR InterPro; IPR035761; SPRY1_RyR.
DR InterPro; IPR035764; SPRY2_RyR.
DR InterPro; IPR035762; SPRY3_RyR.
DR InterPro; IPR003877; SPRY_dom.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF7; RYANODINE RECEPTOR 2; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR Pfam; PF21119; RYDR_Jsol; 1.
DR Pfam; PF02026; RyR; 4.
DR Pfam; PF00622; SPRY; 3.
DR PRINTS; PR00795; RYANODINER.
DR SMART; SM00472; MIR; 4.
DR SMART; SM00449; SPRY; 3.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 2.
DR PROSITE; PS50188; B302_SPRY; 3.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS50919; MIR; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568};
KW Calmodulin-binding {ECO:0000256|ARBA:ARBA00022860};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 4277..4296
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4497..4517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4572..4591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4708..4729
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4766..4787
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 4842..4865
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 108..163
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 223..278
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 284..343
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 349..406
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT DOMAIN 597..807
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1023..1220
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 1355..1560
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT DOMAIN 4020..4055
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1854..1884
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2352..2377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4207..4227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4333..4358
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 4415..4466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1866..1884
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4209..4227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 4337..4358
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4965 AA; 564761 MW; 5CE66B5A6A1FAC8D CRC64;
MSNLIFFSFS LSLQDDEVVL QCTATIHKEQ QKLCLAAEGF GNRLCFLEST SNSKNVPPDL
SICTFVLEQS LSVRALQEML ANTVEKSEGQ VDVEKWKFMM KTAQGGGHRT LLYGHAILLR
HSYSGMYLCC LSTSRSSTDK LAFDVGLQED TTGEACWWTI HPASKQRSEG EKVRVGDDLI
LVSVSSERYL HLSYGNGSLH VDAAFQQTLW SVAPISSGSE AAQGYLIGGD VLRLLHGHMD
ECLTVPSGEH GEEQRRTVHY EGGAVSVHAR SLWRLETLRV AWSGSHIRWG QPSRLRHVTT
GKYLSLMEDK NLLLMDKEKA DVKSTAFSFR SSKEKLDGGV RKEVDGMGTS EIKYGDSICY
IQHVDTGLWL TYQSVDVKSV RMGSIQRKAI MHHEGHMDDG LNLSRSQHEE SRTARVIRST
VFLFNRFIRG LDALSKKAKA SSVDLPIESV SLSLQDLIGY FHPPDEHLEH EDKQNRLRAL
KNRQNLFQEE GMINLVLECI DRLHVYSSAA HFADVAGREA GESWKSILNS LYELLAALIR
GNRKNCAQFS GSLDWLISRL ERLEASSGIL EVLHCVLVES PEALNIIKEG HIKSIISLLD
KHGRNHKVLD VLCSLCVCHG VAVRSNQHLI CDNLLPGRDL LLQTRLVNHV SSMRPNIFLG
VSEGSAQYKK WYYELMVDHT EPFVTAEATH LRVGWASTEG YSPYPGGGEE WGGNGVGDDL
FSYGFDGLHL WSGCIARTVS SPNQHLLRTD DVISCCLDLS APSISFRING QPVQGMFENF
NIDGLFFPVV SFSAGIKVRF LLGGRHGEFK FLPPPGYAPC YEAVLPKEKL KVEHSREYKQ
ERTYTRDLLG PTVSLTQAAF TPIPVDTSQI VLPPHLERIR EKLAENIHEL WVMNKIELGW
QYGPVRDDNK RQHPCLVEFS KLPEQERNYN LQMSLETLKT LLALGCHVGI SDEHAEEKVK
KMKLPKNYQL TSGYKPAPMD LSFIKLTPSQ EAMVDKLAEN AHNVWARDRI RQGWTYGIQQ
DVKNRRNPRL VPYTLLDDRT KKSNKDSLRE AVRTLLGYGY NLEAPDQDHA ARAEVCSGTG
ERFRIFRAEK TYAVKAGRWY FEFEAVTSGD MRVGWSRPGC QPDQELGSDE RAFAFDGFKA
QRWHQGNEHY GRSWQAGDVV GCMVDMNEHT MMFTLNGEIL LDDSGSELAF KDFDVGDGFI
PVCSLGVAQV GRMNFGKDVS TLKYFTICGL QEGYEPFAVN TNRDITMWLS KRLPQFLQVP
SNHEHIEVTR IDGTIDSSPC LKVTQKSFGS QNSNTDIMFY RLSMPIECAE VFSKTVPGGL
PGAGLFGPKN DLEDYDADSD FEVLMKTAHG HLVPDRVDKD KETTKAEFNN HKDYAQEKPS
RLKQRFLLRR TKPDYSTSHS ARLTEDVLAD DRDDYDFLMQ TSTYYYSVRI FPGQEPANVW
VGWITSDFHQ YDTGFDLDRV RTVTVTLGDE KGKVHESIKR SNCYMVCAGE SMSPGQGRNN
NGLEIGCVVD AASGLLTFIA NGKELSTYYQ VEPSTKLFPA VFAQATSPNV FQFELGRIKN
VMPLSAGLFK SEHKNPVPQC PPRLHVQFLS HVLWSRMPNQ FLKVDVSRIS ERQGWLVQCL
DPLQFMSLHI PEENRSVDIL ELTEQEELLK FHYHTLRLYS AVCALGNHRV AHALCSHVDE
PQLLYAIENK YMPGLLRTGY YDLLIDIHLS SYATARLMMN NEFIVPMTEE TKSITLFPDE
NKKHGLPGIG LSTSLRPRMQ FSSPSFVSIN NECYQYSPEF PLDILKAKTI QMLTEAVKEG
SLHARDPVGG TTEFLFVPLI KLFYTLLIMG IFHNEDLRHI LQLIEPSVFK DAATPEEEGD
TLEEEPSVED TKLEGAGEEE AKVGKRPKEG LLQMKLPEPV KLQMCLLLQY LCDCQVRHRI
EAIVAFSDDF VAKLQDNQRF RYNEVMQALN MSAALTARKT KEFRSPPQEQ INMLLNFKDD
KSECPCPEEI RDQLLDFHED LMTHCGIELD EDGSLDGNSD LTIRGRLLSL VEKVTYLKKK
QTEKPVESDS RKSSTLQQLI SETMVRWAQE SVIEDPELVR AMFVLLHRQY DGIGGLVRAL
PKTYTINGVS VEDTINLLAS LGQIRSLLSV RMGKEEEKLM IRGLGDIMNN KVFYQHPNLM
RALGMHETVM EVMVNVLGGG ESKEITFPKM VANCCRFLCY FCRISRQNQK AMFDHLSYLL
ENSSVGLASP AMRGSTPLDV AAASVMDNNE LALALREPDL EKVVRYLAGC GLQSCQMLVS
KGYPDIGWNP VEGERYLDFL RFAVFCNGES VEENANVVVR LLIRRPECFG PALRGEGGNG
LLAAMEEAIK IAEDPSRDGP SPTSGSSKTL DTEEEEDDTI HMGNAIMTFY AALIDLLGRC
APEMHLIHAG KGEAIRIRSI LRSLIPLGDL VGVISIAFQM PTIAKDGNVV EPDMSAGFCP
DHKAAMVLFL DRVYGIEVQD FLLHLLEVGF LPDLRAAASL DTAALSATDM ALALNRYLCT
AVLPLLTRCA PLFAGTEHHA SLIDSLLHTV YRLSKGCSLT KAQRDSIEVC LLSICGQLRP
SMMQHLLRRL VFDVPLLNEH AKMPLKLLTN HYERCWKYYC LPGGWGNFGA ASEEELHLSR
KLFWGIFDAL SQKKYEQELF KLALPCLSAV AGALPPDYME SNYVSMMEKQ SSMDSEGNFN
PQPVDTSNII IPEKLEYFIN KYAEHSHDKW SMDKLANGWI YGEIYSDSSK IQPLMKPYKL
LSEKEKEIYR WPIKESLKTM LAWGWRIERT REGDSMALYN RTRRISQTSQ VSVDAAHGYS
PRAIDMSNVT LSRDLHAMAE MMAENYHNIW AKKKKLELES KGGGNHPLLV PYDTLTAKEK
AKDREKAQDI LKFLQINGYA VSRGFKDLEL DTPSIEKRFA YSFLQQLIRY VDEAHQYILE
FDGGSRSKGE HFPYEQEIKF FAKVVLPLID QYFKNHRLYF LSAASRPLCS GGHASNKEKE
MVTSLFCKLG VLVRHRISLF GNDATSIVNC LHILGQTLDA RTVMKTGLES VKSALRAFLD
NAAEDLEKTM ENLKQGQFTH TRNQPRGVTQ IINYTTVALL PMLSSLFEHI GQHQFGEDLI
LEDVQVSCYR ILTSLYALGT SKSIYVERQR SALGECLAAF AGAFPVAFLE THLNKHNIYS
IYNTKSSRER AALSLPANVE DVCPNIPSLE KLMEEIVELA ESGIRYTQMP HVMEVILPML
CSYMSRWWEH GPESNPGRAE MCCTALNSEH MNTLLGNILK IIYNNLGIDE GAWMKRLAVF
SQPIINKVKP QLLKTHFLPL MEKLKKKAAM VVSEEDHLKA EARGDMSEAE LLILDEFTTL
ARDLYAFYPL LIRFVDYNRA KWLKEPTPEA EELFRMVAEV FIYWSKSHNF KREEQNFVVQ
NEINNMSFLI TDTKSKMSKA AVSDQERKKM KRKGDRYSMQ TSLIVAALKR LLPIGLNICP
GDQELIALAK NRFSLKDTED EVRDIIRNNI HLQGKLEDPA IRWQMALYKD LPNRTEETSD
PEKTVERVLD IANVLFHLEQ KSKFIGRRYY NLVEHPQRSK KAVWHKLLSK QRKRAVVACF
RMAPLYNLPR HRAVNLFLQG YEKSWIETEE HYFEDKLIED LAKPGAEPPE EDEVTKRVDP
LHQLILLFSR TALTEKCKLE EDFLYMAYAD IMAKSCHDEE DDDGEEEVKS FEEKEMEKQK
LLYQQARLHD RGAAEMVLQT ISASKGETGP MVAATLKLGI AILNGGNSTV QQKMLDYLKE
KKDVGFFQSL AGLMQSCSVL DLNAFERQNK AEGLGMVTEE GSGEKVLQDD EFTCDLFRFL
QLLCEGHNSD FQNYLRTQTG NNTTVNIIIS TVDYLLRVQE SISDFYWYYS GKDVIDEQGQ
RNFSKAIQVA KQVFNTLTEY IQGPCTGNQQ SLAHSRLWDA VVGFLHVFAH MQMKLSQDSS
QIELLKELMD LQKDMVVMLL SMLEGNVVNG TIGKQMVDML VESSNNVEMI LKFFDMFLKL
KDLTSSDTFK EYDPDGKGII SKRDFHKAME SHKHYTQSET EFLLSCAETD ENETLDYEEF
VKRFHEPAKD IGFNVAVLLT NLSEHMPNDT RLQTFLELAE SVLNYFQPFL GRIEIMGSAK
RIERVYFEIS ESSRTQWEKP QVKESKRQFI FDVVNEGGEK EKMELFVNFC EDTIFEMQLA
AQISESDLNE RSANKEESEK ERPEEQGPKM GFFSVLTVRS ALFALRYNIL TLMRMLSLKS
LKKQMKKMKK MTVKDMVTAF FSSYWSIFMT LLHFVASVFR GFFRIVCSLL LGGSLVEGAK
KIKVAELLAN MPDPTQDEVR GDGEEGERKP METTLPSEDL TDLKELTEES DLLSDIFGLD
LKREGGQYKL IPHNPNAGLS DLMSNPVLIP EEQEKFQEQK TKEEEKEEKE ETKSEPEKAE
GEDGEKEEKV KEDKGKQKLR QLHTHRYGEP EVPESAFWKK IIAYQQKLLN YFARNFYNMR
MLALFVAFAI NFILLFYKVS TSSVVEGKEL PSRSTSENAK VTTSLDSSSH RIIAVHYVLE
ESSGYMEPTL RILAILHTVI SFFCIIGYYC LKVPLVIFKR EKEVARKLEF DGLYITEQPS
EDDIKGQWDR LVINTQSFPN NYWDKFVKRK VMDKYGEFYG RDRISELLGM DKAALDFSDA
REKKKPKKDS SLSAVLNSID VKYQMWKLGV VFTDNSFLYL AWYMTMSILG HYNNFFFAAH
LLDIAMGFKT LRTILSSVTH NGKQLVLTVG LLAVVVYLYT VVAFNFFRKF YNKSEDGDTP
DMKCDDMLTC YMFHMYVGVR AGGGIGDEIE DPAGDEYEIY RIIFDITFFF FVIVILLAII
QGLIIDAFGE LRDQQEQVKE DMETKCFICG IGNDYFDTVP HGFETHTLQE HNLANYLFFL
MYLINKDETE HTGQESYVWK MYQERCWEFF PAGDCFRKQY EDQLN
//
