ID G1SHP7_RABIT Unreviewed; 446 AA.
AC G1SHP7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Differentially expressed in FDCP 8 homolog {ECO:0000313|Ensembl:ENSOCUP00000002160.3};
GN Name=DEF8 {ECO:0000313|Ensembl:ENSOCUP00000002160.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000002160.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000002160.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000002160.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000002160.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DEF8 family.
CC {ECO:0000256|ARBA:ARBA00029450}.
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DR AlphaFoldDB; G1SHP7; -.
DR SMR; G1SHP7; -.
DR STRING; 9986.ENSOCUP00000002160; -.
DR PaxDb; 9986-ENSOCUP00000002160; -.
DR Ensembl; ENSOCUT00000002496.3; ENSOCUP00000002160.3; ENSOCUG00000002498.3.
DR eggNOG; KOG1829; Eukaryota.
DR GeneTree; ENSGT00940000159182; -.
DR HOGENOM; CLU_034500_1_1_1; -.
DR InParanoid; G1SHP7; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000002498; Expressed in uterus and 14 other cell types or tissues.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0032418; P:lysosome localization; IEA:Ensembl.
DR GO; GO:0045780; P:positive regulation of bone resorption; IEA:Ensembl.
DR GO; GO:1900029; P:positive regulation of ruffle assembly; IEA:Ensembl.
DR CDD; cd20819; C1_DEF8; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR047983; DEF8_C1.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR025258; RH_dom.
DR PANTHER; PTHR12326:SF3; DIFFERENTIALLY EXPRESSED IN FDCP 8 HOMOLOG; 1.
DR PANTHER; PTHR12326; PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF13901; RH_dom; 1.
DR SMART; SM00109; C1; 2.
DR SMART; SM01175; DUF4206; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 156..207
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 446 AA; 51659 MW; 97CA367BFDF8266A CRC64;
LSQERGTQKR GGEKRWSTRG DAMEYDEKLA RFRQAHLNPF NKQLGPRQHE QGPREEVLEV
TLPELPLGEP EFRCTERVMD LGLSEDHFSR PVGLFLASDI QQLRQAIEEC KQLILELPEQ
SEQQKDAVVR LIHLRLKLQE LKDPSEDEPN IRVLLQHRFY KEKSKSVKQT CDKCNTIIWG
LIQTWYTCTG CCYRCHSKCL NLISKPCVSS KVSHQAEYEL NICPETGLDS QDYRCVECRA
LISLRECWWG QSEMGLWSGQ LVTLCHPEDE VGDHRLPMNR RRRGGRATPA SWLRPSPSAH
LQKLRQDILL MKPYFITCKE AMEARLLLQL QDRQHFVEND EMYSVQDLLD VHMGRLGCSL
TEIHTLFAKH IKLDCERCQA KGFVCELCRE GDVLFPFDSH TSVCTDCSAV FHRDCYYDNS
TTCPKCARLT LRKQSLFQEP GPEEDA
//
