ID G1SI06_RABIT Unreviewed; 1103 AA.
AC G1SI06;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 24-JAN-2024, entry version 64.
DE RecName: Full=GPI ethanolamine phosphate transferase 3 {ECO:0000256|ARBA:ARBA00020841};
GN Name=PIGO {ECO:0000313|Ensembl:ENSOCUP00000002293.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000002293.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000002293.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000002293.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000002293.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000002293.3};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- PATHWAY: Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor
CC biosynthesis. {ECO:0000256|ARBA:ARBA00004687}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.
CC {ECO:0000256|ARBA:ARBA00008695}.
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DR EMBL; AAGW02033496; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008269131.1; XM_008270909.2.
DR AlphaFoldDB; G1SI06; -.
DR PaxDb; 9986-ENSOCUP00000002293; -.
DR Ensembl; ENSOCUT00000002654.4; ENSOCUP00000002293.3; ENSOCUG00000002653.4.
DR GeneID; 100339282; -.
DR KEGG; ocu:100339282; -.
DR CTD; 84720; -.
DR eggNOG; KOG2126; Eukaryota.
DR GeneTree; ENSGT00910000144278; -.
DR HOGENOM; CLU_004298_2_0_1; -.
DR OMA; LGDSTWT; -.
DR OrthoDB; 5479199at2759; -.
DR UniPathway; UPA00196; -.
DR Proteomes; UP000001811; Chromosome 1.
DR Bgee; ENSOCUG00000002653; Expressed in uterus and 14 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0051377; F:mannose-ethanolamine phosphotransferase activity; IEA:InterPro.
DR CDD; cd16023; GPI_EPT_3; 1.
DR Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR InterPro; IPR002591; Phosphodiest/P_Trfase.
DR InterPro; IPR037675; PIG-O_N.
DR InterPro; IPR039524; PIGO/GPI13.
DR PANTHER; PTHR23071:SF1; GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3; 1.
DR PANTHER; PTHR23071; PHOSPHATIDYLINOSITOL GLYCAN; 1.
DR Pfam; PF01663; Phosphodiest; 1.
DR SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor biosynthesis {ECO:0000256|ARBA:ARBA00022502};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..42
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 467..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 491..513
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 520..539
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 559..579
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 680..700
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 715..734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 746..772
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 843..862
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 869..891
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 956..975
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1030..1050
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1062..1084
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 981..1003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 983..997
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1103 AA; 120130 MW; BAA8FF320F16B2F8 CRC64;
MRWLGSGTVY LQMQKVSVLL FLAWVCLLFY AGIALFTSGF LLTRLELTNH SSCQEPPGPG
SLPWGHRGQP GACWMAAQFS RVVLVLIDAL RFDFAQPQRS HGSGEPPASL PFLGKLGSLQ
RILETEPHRA RLYRAQVDPP TTTMQRLKAL TTGSLPTFVD AGSNFASHAI VEDNLIKQLN
SAGRRIVFMG DDTWKALFPG AFSQAFFFPS FNTRDLHTVD NGILEHLYPT MDSGEWDVLI
AHFLGVDHCG HRHGPHHPEM AKKLSQMDQV IQGLVERLEN DTLLVVAGDH GMTVSGDHGG
DSELEVSAAL FLYSPTALFP STPPEEPEVI PQISLVPTLA LLLGLPIPFG NIGEVIAELF
SGGKDSQPLS SALAQASALH INAQQVSRFL HTYSAATQDF HVEELRRLQN LFSKASADYQ
WLLKNPQGAE ETLKAVTAEL QQFLRGARAV CIEFWARFSL VRMAGGAALL AAACFLCMLA
SQWATSPAFP FYSLLLMPVA WGVTGAVVCA GLLATTGLKL DAVVLAAVAA VGSLLPFLWK
AWAGWGPRRP LTSLLPIPRP ILLLLLIRLA AFFSDSFVVA EAKATPFLLG SLILLLVVQL
HWEGQMLPPK LLTIPRLGSS APTGLPRHSG TYALRLGVGL LLCTRLAGLF HRCPEETPAC
HSSPWLNPLA SMVGGRAKNL WYGACVGALV ALLAAVRLWL RHYGNLKSPE PPVLFVRWGL
PLMALGTAAY WALASGAEEA PPRLRALVAG ASAVLPRAVV GLAAAGLVLL LWRPVTVLVK
AGASAPRTRT VLTPFSGPPT SQADLDYVVP QIYRHMQEEF RGRLERTRSE GPLTVAAYQL
GSVYSAAMVT ALTLLAFPLL LLHTERISLV FLLLFLQSFL LLHLLAAGIP VPRPGPFTVP
WQAVSAWALM ATQTFYSTGH QPVFPAIHWH AAFVGFPEGH GSSTWLPALL VGANTFASHL
LFAVGCPLLL LWPFLCESQG PKRRQHPPGH EAEAKVRPEE EEEEEPLMEM RLREAPHHFN
AALLQLGLKY LFVLGVQILA CVLAASILRR HLMVWKVFAP KFIFEALGFI VSSVGLLLGI
ALVMRVDGAV SSWFRQLVLS QQR
//