ID G1SIY5_RABIT Unreviewed; 480 AA.
AC G1SIY5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Chitobiase {ECO:0000313|Ensembl:ENSOCUP00000002659.3};
GN Name=CTBS {ECO:0000313|Ensembl:ENSOCUP00000002659.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000002659.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000002659.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000002659.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000002659.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000002659.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Lysosome {ECO:0000256|ARBA:ARBA00004371}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 18 family.
CC {ECO:0000256|ARBA:ARBA00009336, ECO:0000256|RuleBase:RU004453}.
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DR EMBL; AAGW02001717; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SIY5; -.
DR SMR; G1SIY5; -.
DR STRING; 9986.ENSOCUP00000002659; -.
DR PaxDb; 9986-ENSOCUP00000002659; -.
DR Ensembl; ENSOCUT00000003057.4; ENSOCUP00000002659.3; ENSOCUG00000003059.4.
DR eggNOG; KOG2806; Eukaryota.
DR GeneTree; ENSGT00390000012891; -.
DR HOGENOM; CLU_061189_1_0_1; -.
DR InParanoid; G1SIY5; -.
DR TreeFam; TF332677; -.
DR Proteomes; UP000001811; Chromosome 13.
DR Bgee; ENSOCUG00000003059; Expressed in liver and 17 other cell types or tissues.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-SubCell.
DR GO; GO:0008061; F:chitin binding; IEA:InterPro.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd02875; GH18_chitobiase; 1.
DR Gene3D; 3.10.50.10; -; 1.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR011583; Chitinase_II.
DR InterPro; IPR029070; Chitinase_insertion_sf.
DR InterPro; IPR047898; DIAC_cat.
DR InterPro; IPR001223; Glyco_hydro18_cat.
DR InterPro; IPR001579; Glyco_hydro_18_chit_AS.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR46290; DI-N-ACETYLCHITOBIASE; 1.
DR PANTHER; PTHR46290:SF1; DI-N-ACETYLCHITOBIASE; 1.
DR Pfam; PF00704; Glyco_hydro_18; 1.
DR SMART; SM00636; Glyco_18; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
DR PROSITE; PS01095; GH18_1; 1.
DR PROSITE; PS51910; GH18_2; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 89..480
FT /note="GH18"
FT /evidence="ECO:0000259|PROSITE:PS51910"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 48..98
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..71
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 480 AA; 53809 MW; E5C2E7F16104B92E CRC64;
MSTQATRETR RVTNTRESQL PVEQGFSVGR LLGVQHWLIP GTRPGRPLTP SWLPARPCPH
LPRPPRPAPR GPRGKSSRAR QEEPTSVARR SAGMAGPQLR GRRLLARRPP LPLPLPPPLL
LLLPLLTPVP AAGNHCPCRE PALCLPIRQR PDFEVFVFHV GQKTWKSYDW TQITTVAVFG
RYNSELMCHA HSKGARVVLK GDVSLKKITD PTFRASWIAE KLKLAKAQHM DGINIDIEQE
VTCSSPEYDA LTALVKETTD AFHHEIEGSQ VTFDVAWSPK NIDGRCYNYT GIADACDFLF
VMSYDEQSQV WSECIAAANA PFNQTLTGYR DYIKMGINPK KLVMGVPWYG YDYTCLNLSE
SHVCTIAKVP FRGAPCSDAA GHQVPYKVIM KEIHSSISGS QWDEDQQAPY YNYKDPSGQL
HQVWYDNPRS ISLKAEHIPQ YGLRGIGMWN ADCLDYSGGA VAKQQTEEMW KALKPKPAQR
//
