ID G1SK43_RABIT Unreviewed; 1299 AA.
AC G1SK43;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Cingulin like 1 {ECO:0000313|Ensembl:ENSOCUP00000003157.3};
GN Name=CGNL1 {ECO:0000313|Ensembl:ENSOCUP00000003157.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000003157.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000003157.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000003157.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000003157.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000003157.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02024949; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02024950; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02024951; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02024952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02024953; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02024954; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; G1SK43; -.
DR STRING; 9986.ENSOCUP00000003157; -.
DR PaxDb; 9986-ENSOCUP00000003157; -.
DR Ensembl; ENSOCUT00000003639.3; ENSOCUP00000003157.3; ENSOCUG00000003637.3.
DR eggNOG; ENOG502QSXG; Eukaryota.
DR GeneTree; ENSGT00940000154489; -.
DR HOGENOM; CLU_002036_2_1_1; -.
DR InParanoid; G1SK43; -.
DR TreeFam; TF332247; -.
DR Proteomes; UP000001811; Chromosome 17.
DR Bgee; ENSOCUG00000003637; Expressed in kidney and 16 other cell types or tissues.
DR GO; GO:0005923; C:bicellular tight junction; IEA:Ensembl.
DR GO; GO:0016459; C:myosin complex; IEA:InterPro.
DR GO; GO:0007015; P:actin filament organization; IEA:Ensembl.
DR GO; GO:0051058; P:negative regulation of small GTPase mediated signal transduction; IEA:Ensembl.
DR GO; GO:0051497; P:negative regulation of stress fiber assembly; IEA:Ensembl.
DR GO; GO:0150105; P:protein localization to cell-cell junction; IEA:Ensembl.
DR InterPro; IPR002928; Myosin_tail.
DR PANTHER; PTHR46349:SF2; CINGULIN-LIKE PROTEIN 1; 1.
DR PANTHER; PTHR46349; CINGULIN-LIKE PROTEIN 1-RELATED; 1.
DR Pfam; PF01576; Myosin_tail_1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 1013..1252
FT /note="Myosin tail"
FT /evidence="ECO:0000259|Pfam:PF01576"
FT REGION 104..135
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 161..209
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 242..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..441
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 448..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 587..607
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 653..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 879..921
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1257..1299
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..208
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..389
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 587..605
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 879..898
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1299 AA; 148417 MW; A273737F783FE6F2 CRC64;
MELYFGEYQH VQQEYGVHLR LASDETKKPR NFQHSKAGSY GVSIRVQGID GHPYIVLNNT
ERCLAGSSFP ENGPTCPSPV VSNLPVHSNR GSVLKNRAEE LQLPENPYAQ PSPIRNLKQP
SVHEGKNGVL ERKDGPMKST HVLNFQRHPE LLQPYDPEKN ELSLQNHQSP ESNWLKPLAE
EPTNGKKPWT CFPKPTSSQP TSTPLEDLGK PNVTAIRVCS SVVIDDPKKQ TSVCVNVQSC
TKEGVPEEGA SPSGRPVSAY SPHAHSETKK TRPDVLPFRR QDSAGPVLDG ARSRRSSSSS
TTPTSVNSLY RFLLDDQECA IHADNVNRHE NRRYIPFLPG TGRDIDTGSI AGVDQLIEKF
DQKSGLQRRG RSGKRNRINP DDRKRSRSVD SAFPFGLQGN SEYLTEFSRH LGKSSEHLLR
PSQVCPQRPQ SQERRGKQSV GRTFAKLQGA VQDAHPRPPQ LTKDGKVLED KGGWESTATC
ASSPLASSKK EEEVKTATAT LKLQSRSVAT SPDSGVKKVS VKAFPSTSST QATPDLLKGQ
QELTQQTNEE TAKQILYNYL KEGSTDNDDA TKRKVNLVFE KIQTLKSRAA GSPQANNQAS
DSSSEVKDLL EQKNKLTLEV AELQRQLQLE IKNQENIKDE RERMRANLEA LRSQHDSKVE
ENSVLKQRLE ESEGELRKNL EELFQVKMER EQHQTEIRDL QDQLSEMHDE LDSAKQSEDS
EKSALIEELL QAKQDLQDLL ITKEEQEDLL RKRERELTAL KGALKEEVSS HDQEMDKLKE
QYDAELQALR ESVEEATKNV EVLASRSSAS EQNKVGAEMR EQLLKEENEK LQGRIGELER
RAAQLQRHVS DLKGDEAKAK DTLQKYEGQV RQLEEALAHA RKEEKEATSA RKTLENELTD
AQRSLSRTTQ EKQLSEQLKD EVEQKEQLRR LKNDMENERW HLDKTIEKLQ KEMADIVEAS
RTSTLELQNQ LDEYKEKNRR ELADMQRQLK EKTLEVEKSR LAAVKMQDEM RLMEEELRDY
QRAQDEALTK RQLLEQTLKD LEYELEAKSH LRDDRGRLVK QLEDKVSQLE MELEEERNNS
DLLSERITRS REQMEQVRSE LLQERAVRQD LECDKISLER QNKDLKSRII HLEGSYRSSK
DGLVAQMEAR IAELEERLQS EERDRASLQL SNRRLERKVK ELVLQVDDEH LSLTDQKDQL
SLRLKAMKRQ VEEAEEEIDR LESSKKKLQR ELEEQMDVNE QLQGQLSSMK KDLRLKKLPS
KVLDDVDDDD DDLSTDGGSL YEAPLSYTYP KDSTLTSQI
//
