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Database: UniProt
Entry: G1SKB4_RABIT
LinkDB: G1SKB4_RABIT
Original site: G1SKB4_RABIT 
ID   G1SKB4_RABIT            Unreviewed;      1544 AA.
AC   G1SKB4;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   13-NOV-2013, sequence version 2.
DT   22-NOV-2017, entry version 31.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|Ensembl:ENSOCUP00000003244};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000003244, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000003244, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000003244}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000003244};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000003244}.
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DR   EMBL; AAGW02048491; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02048492; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02048493; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOCUT00000003744; ENSOCUP00000003244; ENSOCUG00000003734.
DR   eggNOG; ENOG410KCT9; Eukaryota.
DR   eggNOG; ENOG411219K; LUCA.
DR   GeneTree; ENSGT00760000119127; -.
DR   InParanoid; G1SKB4; -.
DR   OMA; NERMAMK; -.
DR   OrthoDB; EOG091G0DHL; -.
DR   Proteomes; UP000001811; Chromosome 1.
DR   Bgee; ENSOCUG00000003734; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0005261; F:cation channel activity; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro.
DR   GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR   Gene3D; 1.20.5.1010; -; 1.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR004166; MHCK_EF2_kinase.
DR   InterPro; IPR029597; TRPM6.
DR   InterPro; IPR032415; TRPM_tetra.
DR   InterPro; IPR037162; TRPM_tetra_sf.
DR   PANTHER; PTHR13800:SF15; PTHR13800:SF15; 1.
DR   Pfam; PF02816; Alpha_kinase; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF16519; TRPM_tetra; 1.
DR   SMART; SM00811; Alpha_kinase; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51158; ALPHA_KINASE; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    364    383       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    500    520       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    577    600       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    621    640       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1273   1502       Alpha-type protein kinase.
FT                                {ECO:0000259|PROSITE:PS51158}.
SQ   SEQUENCE   1544 AA;  177463 MW;  17E1207EF99F11C4 CRC64;
     MFLLQHTLLS NYKITLIDIG LVIEHLIGGA YRSSYTRKNF RALYNNFYRT YKGANSFPQS
     LSQHSLHRRR HSGTRNESAE STLHSQFIRT AQPYKVKEKS ATVLHKSRKK SKDGQTLSDD
     PESPGFTYPY NDLLVWAVLM KRQRMAMFFW QHGEEATVKA VIACILYQAM AREAEENNMV
     DDTSEELKNY SKQFSQLALD VLEKAFKQNE RMAMKLLTCE LKNWSNSTCL KLAVSGGLQP
     VVSHSCTQML LTDMWTGRLK MRKNSWLKII ISILLPPTIL TLEFKSKAEM SHVPQSQDFQ
     FTWYYGDQNP STTKENACPK NHDLEKGSDE KQDENQHFDI KNGPKSLPWT RKLYEFYCAP
     IVKFWFYTMA YLAFLMLFTY TVLVEMQPQP SVQEWLVIIY IITSALEKAR EIYISEPVKF
     TQKVKVWISD YWNLMESVAI CLFLVGFGLR WGEPPFRTAG RLIYCIDTIF WYTQLLDFFA
     VNQHAGPYVT MIAKMTANMF YIVIIMAIVL LSFGVARKAI LSPKEPPSWS LARDIVFEPY
     WMMYGEVYAS EIDVCESTPS CPPGSFLTPF LQAVYLFVQY IIMVNLLISF CNNVYVEMIS
     VSNKLWRYNR YRYIMTYHEK LWLPPPFILL SYVGLLLRHL CCQRTPNDQE EGDVGLKLYL
     SKEDLKKLHD FEEECVEKYF HEKMECLNCS SEERIRVTSE RVTEMYLHMK EMNEKVSFIK
     DSLLSLDSQV GHLQDLSALT VDTLKVLSAV DTLQEDKALL AKRKHPTCRK VPHSWNNVIC
     AEMLGSVGLS GGKKLQYYSM PPSLLRSLAR SQHQLGSQRQ VLLEITDSQR ETTSVSDDQK
     QQATETRIVA SGMSLNRQAH SKYGKFLLVP SYLKQVPFSA ETILPPSRPS MEAKEDVLAT
     EQVYQSEVTD HPNWQTPVVS EQASVAEPQE QDEPVTQTPD KQDKVEQTLP TLSCTPTPLA
     MTSLPSQAKS SYTGGGYVNW AFSEGNEPGV FSIKRKWQTC LPSTHSSDST QSEQSQMQSQ
     SGSLSENPTR LAQTSDCSEK RPWLQPHTSF WISSLCRDKS FFRSHSFRFY KEEKLMKICK
     SKTNSRYSET GAAWIKAKML TNKRLPKKKK KTQGLQVPVI TVNTCCRSDQ LESEPGKDNT
     AEENCSKTWL TVSGLGHQGL EPYRYQKMKT KEIEQQSIQV GDSLKQSQED LKEASLWNSR
     STNLSRSSLL RSSDGVDKIP ASLKSPQESH HHYSAIERNN LMRLSQNIPF TPIQLFAGEE
     VTVYRLEESS PMNLDKSMSS WSQRGRSAMI QVLSREEMGG LRRAMRVIST LSEDDVLEPG
     QVFIVKSFLP EVVQTWYKIF QESTVLHLCL REIQQQRAAQ KLIYTFNQVK PHTIRYTPRF
     LEVFLIYCHS ANQWLTIEKY MTGEFRKYNN NNGDEITPRN TLEELMLAFS HWTYEYTRGE
     LLVLDLQGVG ENLTDPSVIK PEDKQSRGMV FGPANLGEDA IRNFIAKHRC NSCCRKLKLP
     DLKRNDYSPG RINSTLGLDI KKEPPEGPSE KERDGNSPED HTRL
//
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