ID G1SKJ3_RABIT Unreviewed; 1518 AA.
AC G1SKJ3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Rap guanine nucleotide exchange factor 6 {ECO:0000313|Ensembl:ENSOCUP00000003337.3};
GN Name=RAPGEF6 {ECO:0000313|Ensembl:ENSOCUP00000003337.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000003337.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000003337.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000003337.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000003337.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000003337.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
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DR EMBL; AAGW02027932; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02027933; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02027934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02027935; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PaxDb; 9986-ENSOCUP00000003337; -.
DR Ensembl; ENSOCUT00000003850.3; ENSOCUP00000003337.3; ENSOCUG00000003847.3.
DR eggNOG; KOG3542; Eukaryota.
DR GeneTree; ENSGT00940000158124; -.
DR HOGENOM; CLU_002782_0_1_1; -.
DR TreeFam; TF313184; -.
DR Proteomes; UP000001811; Chromosome 3.
DR Bgee; ENSOCUG00000003847; Expressed in testis and 14 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 1.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01785; RA_PDZ-GEF1; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45161; CYTOSKELETON-ASSOCIATED PROTEIN 4; 1.
DR PANTHER; PTHR45161:SF4; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 6; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00595; PDZ; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR SMART; SM00100; cNMP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 193..293
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 325..439
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 443..513
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 662..748
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 773..1004
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 89..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 985..1004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1105..1188
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1203..1245
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1367..1395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1413..1518
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1111..1128
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1138..1188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1203..1217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1454..1497
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1518 AA; 169583 MW; 74A06F691C703EE0 CRC64;
MVLPPCSFGK QFGGKRGCDC LVLEPSEMIV VENSKDNEDS FLQREIPARQ SRRRFRKINY
KGERQTITDN VDINSYLSLP ADLTKMHLTD SPHPQVTHVS SSQSGCSIAS DSGSSSLSDI
YQATESEVGD VDLTRLPEGP VDSEDEEEDD EEIDRTDPLH GRDLVRECLE KEPADKTDDD
IEQLLEFMHQ LPAFANMTMS VRRELCSVMI FEVVEQAGAI ILEDGQELDS WYVILNGTVE
ISHPDGKVEN LFMGNSFGIT PSLDKQYMHG VVRTKVDDCQ FVCIAQQDYW RILNHVEKNT
HKVEEEGEIV MVHEHRELDR SGTRKGHIVI KATPERLIMH LIEEHSIVDP TYIEDFLLTY
RTFLESPLDV GIKLLEWFKI DSLRDKVTRI VLLWVNNHFN DFEGDPAMTR FLEEFEKHLE
DTKMNGHLRL LNIACAAKAK WRQVVLQKAS RESPLHFSLN GGSEKGFGVF VEGVEPGSKA
ADAGLKRGDQ IMEVNGQNFE NITIVKALEI LRNNTHLALT VKTNIFVFKE LLSRTEQEKS
GIPHIPKIAE KKSNRHSIQD VPGDIEQTSQ EKGSKKVKAN TVSGGRNKIR KILDKTRFSI
LPPKLFSDGG LSQSQDDSIV GTRHCRHSLA IMPIPGTLSS SSPDLLQPTT SMLDFSNPSD
IPDQVIRVFK ADQQSCYIII SKDTTAKEVV CHAVHEFGLA GASDTYSLCE VSVTPEGVIK
QRRLPDQFSK LADRIQLNGR YYLKNNMETE TLCSDEDAQE LVKESQLSML QLSTIEVATQ
LSMRDFDLFR NIEPTEYIDD LFKLDSKIGN THLKAFEDIV NQETFWVASE ILTESNQLKR
MKIIKHFIKI ALHCRECKNF NSMFAIISGL NLAPVARLRG TWEKLPSKYE KHLQDLQDLF
DPSRNMAKYR NILSSQSMQP PIIPLFPVVK KDMTFLHEGN DSKVDGLVNF EKLRMIAKEI
RQVIRMTSAN MDPAMMFRQR SLSQGSTNSN MLDIQGGSHK KRARRSSLLN AKKLYEDAQM
ARKVKQYLSG LDVETDEEKF QMMSLQWEPA YGTLPKNVNE KRSAKSSEMS PVPMRSAGQI
AKVHLHQPHR VSQVLQVPAV NLHPIRKRGQ TKDSALSTSL PQKVLGTTDE TSSKKHTEDT
LSVASSLHSS PPASPQGSPR KSYTLTPSAK SDNFSDSSHS EISSRSSIVS NCSVDSMSAA
LQDERCSSQV LTVPESTRTL EKTEHPSGTG DHSHHGPGGT LSKPSLIKGL AVSSSMSSEE
ISHEHIIIEA ADSGRGSWTS CSSSSHDNFQ SLPNPKSWDF LNSYRHTHLD DPIAEVEPTD
CESYSCPKGC SRTCSQCKGS LESNRSRQSW ASSSSLSDTF EPNYGTVKRR VLESGPAEST
EGMDSKDATD PVYKTVTSST EKGLIVYCVT SPKKDNRYRE PPPTPPGYMG ISLADLKEGP
HPHLKPPDYS VAVQRSKMMQ NSLSRLPPAS PSSNPVACVS STILTQPQRQ NPQPSHPKLA
DVTDADSEAD ENEQVSAV
//
