ID G1SKL7_RABIT Unreviewed; 323 AA.
AC G1SKL7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=BRCA1 DNA repair associated {ECO:0000313|Ensembl:ENSOCUP00000003362.3};
GN Name=BRCA1 {ECO:0000313|Ensembl:ENSOCUP00000003362.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000003362.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000003362.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000003362.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000003362.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000003362.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02039774; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02039775; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02039776; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SKL7; -.
DR PaxDb; 9986-ENSOCUP00000003362; -.
DR Ensembl; ENSOCUT00000003877.4; ENSOCUP00000003362.3; ENSOCUG00000003883.4.
DR eggNOG; KOG1197; Eukaryota.
DR GeneTree; ENSGT00440000034289; -.
DR HOGENOM; CLU_026673_3_1_1; -.
DR TreeFam; TF314255; -.
DR Proteomes; UP000001811; Chromosome 19.
DR Bgee; ENSOCUG00000003883; Expressed in uterus and 15 other cell types or tissues.
DR ExpressionAtlas; G1SKL7; baseline.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08275; MDR3; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR PANTHER; PTHR44054:SF1; SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG; 1.
DR PANTHER; PTHR44054; SYNAPTIC VESICLE MEMBRANE PROTEIN VAT-1 HOMOLOG-LIKE; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 27..315
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
FT REGION 1..54
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 323 AA; 34695 MW; 633767C2BFA6EAB3 CRC64;
MSAEREVAEA GAGEDTTSQP PKAEAASDPQ PPVASEGEAA APPPPLRSLG LTGFGGYDKT
GDRVMVLNRS GMWQEEVTVP SAQTFLMPEA MTFEEAAALL VNYITAYMVL FDFGNLRPGH
SVLVHMAAGG VGMAAVQLCR TVENVTVFGT ASASKHKALQ ENGVTHAIDY HTADYVDEIK
KISPRGVDIV MDPLGGSDTA KGYNLLKPMG KVITYGMANL LTGPKRNLMA LARTWWNQFS
VTALQLLQAN RAVCGFHLGY LEGEVELVSG VVARLLALYN QGRIKPHIDS VWPFEKVADA
MKQMQEKKNV GKVLLVPGPE KAN
//
