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Database: UniProt
Entry: G1SKY7_RABIT
LinkDB: G1SKY7_RABIT
Original site: G1SKY7_RABIT 
ID   G1SKY7_RABIT            Unreviewed;       330 AA.
AC   G1SKY7;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   11-DEC-2019, sequence version 3.
DT   24-JAN-2024, entry version 59.
DE   RecName: Full=TAR DNA-binding protein 43 {ECO:0000256|ARBA:ARBA00018889};
GN   Name=TARDBP {ECO:0000313|Ensembl:ENSOCUP00000003504.4};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000003504.4, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000003504.4, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000003504.4}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000003504.4};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC       Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; G1SKY7; -.
DR   SMR; G1SKY7; -.
DR   STRING; 9986.ENSOCUP00000003504; -.
DR   PaxDb; 9986-ENSOCUP00000003504; -.
DR   Ensembl; ENSOCUT00000004049.4; ENSOCUP00000003504.4; ENSOCUG00000004049.4.
DR   eggNOG; ENOG502QPQ8; Eukaryota.
DR   GeneTree; ENSGT00940000154343; -.
DR   HOGENOM; CLU_012062_6_0_1; -.
DR   InParanoid; G1SKY7; -.
DR   TreeFam; TF315657; -.
DR   Proteomes; UP000001811; Unplaced.
DR   Bgee; ENSOCUG00000004049; Expressed in ovary and 15 other cell types or tissues.
DR   GO; GO:0043232; C:intracellular non-membrane-bounded organelle; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0003690; F:double-stranded DNA binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0140693; F:molecular condensate scaffold activity; IEA:Ensembl.
DR   GO; GO:0003730; F:mRNA 3'-UTR binding; IEA:Ensembl.
DR   GO; GO:0061158; P:3'-UTR-mediated mRNA destabilization; IEA:Ensembl.
DR   GO; GO:0070935; P:3'-UTR-mediated mRNA stabilization; IEA:Ensembl.
DR   GO; GO:1990000; P:amyloid fibril formation; IEA:Ensembl.
DR   GO; GO:0043922; P:negative regulation by host of viral transcription; IEA:Ensembl.
DR   GO; GO:0001933; P:negative regulation of protein phosphorylation; IEA:Ensembl.
DR   GO; GO:0071765; P:nuclear inner membrane organization; IEA:Ensembl.
DR   GO; GO:0042981; P:regulation of apoptotic process; IEA:Ensembl.
DR   GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl.
DR   GO; GO:0031647; P:regulation of protein stability; IEA:Ensembl.
DR   GO; GO:0008380; P:RNA splicing; IEA:Ensembl.
DR   CDD; cd12321; RRM1_TDP43; 1.
DR   CDD; cd12322; RRM2_TDP43; 1.
DR   Gene3D; 3.30.70.330; -; 2.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR000504; RRM_dom.
DR   InterPro; IPR049124; TDP-43_C.
DR   PANTHER; PTHR48033; RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN; 1.
DR   PANTHER; PTHR48033:SF9; TAR DNA-BINDING PROTEIN 43; 1.
DR   Pfam; PF00076; RRM_1; 2.
DR   Pfam; PF20910; TDP-43_C; 1.
DR   SMART; SM00360; RRM; 2.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR   PROSITE; PS50102; RRM; 2.
PE   4: Predicted;
KW   Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT   DOMAIN          20..116
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   DOMAIN          107..178
FT                   /note="RRM"
FT                   /evidence="ECO:0000259|PROSITE:PS50102"
FT   REGION          177..219
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          257..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   330 AA;  35174 MW;  C87E0A99B5EC7133 CRC64;
     MDETDASSAV KVKRAVQKTS DLIVLGLPWK TTEQDLKEYF STFGEVLMVQ VKKDIKTGHS
     KGFGFVRFTE YETQVKVMSQ RHMIDGRWCD CKLPNSKQSP DEPLRSRKVF VGRCTEDMTA
     DELQQFFCQY GEVVDVFIPK PFRAFAFVTF ADDQVAQSLC GEDLIIKGIS VHISNAEPKH
     NSNRQLERSG RFGGNPGGFG NQGGFGNSRG GGAGLGNNQG SNMGGGMNFG AFSINPAMMA
     AAQAALQSSW GMMGMLASQQ SQSGPSGNNQ SQGNMQREPN QAFGSGNNSY SGSNSGAAIG
     WGSASNAGSG SGFNGGFGSS MDSKSSGWGM
//
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