ID G1SL30_RABIT Unreviewed; 617 AA.
AC G1SL30;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Ectonucleoside triphosphate diphosphohydrolase 4 {ECO:0000313|Ensembl:ENSOCUP00000003554.3};
GN Name=ENTPD4 {ECO:0000313|Ensembl:ENSOCUP00000003554.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000003554.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000003554.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000003554.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000003554.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000003554.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the GDA1/CD39 NTPase family.
CC {ECO:0000256|ARBA:ARBA00009283, ECO:0000256|RuleBase:RU003833}.
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DR EMBL; AAGW02011148; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002709361.1; XM_002709315.3.
DR RefSeq; XP_008247768.1; XM_008249546.2.
DR AlphaFoldDB; G1SL30; -.
DR SMR; G1SL30; -.
DR STRING; 9986.ENSOCUP00000003554; -.
DR PaxDb; 9986-ENSOCUP00000003554; -.
DR Ensembl; ENSOCUT00000004106.4; ENSOCUP00000003554.3; ENSOCUG00000004102.4.
DR GeneID; 100345399; -.
DR KEGG; ocu:100345399; -.
DR CTD; 9583; -.
DR eggNOG; KOG1386; Eukaryota.
DR GeneTree; ENSGT01100000263540; -.
DR HOGENOM; CLU_010246_6_0_1; -.
DR InParanoid; G1SL30; -.
DR OMA; WHDALFD; -.
DR OrthoDB; 180318at2759; -.
DR TreeFam; TF354343; -.
DR Proteomes; UP000001811; Chromosome 2.
DR Bgee; ENSOCUG00000004102; Expressed in skeletal muscle tissue and 15 other cell types or tissues.
DR GO; GO:0000421; C:autophagosome membrane; IEA:Ensembl.
DR GO; GO:0000139; C:Golgi membrane; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0036384; F:CDP phosphatase activity; IEA:Ensembl.
DR GO; GO:0043273; F:CTPase activity; IEA:Ensembl.
DR GO; GO:0004382; F:GDP phosphatase activity; IEA:Ensembl.
DR GO; GO:0045134; F:UDP phosphatase activity; IEA:Ensembl.
DR GO; GO:0046036; P:CTP metabolic process; IEA:Ensembl.
DR GO; GO:0046712; P:GDP catabolic process; IEA:Ensembl.
DR GO; GO:0034656; P:nucleobase-containing small molecule catabolic process; IEA:Ensembl.
DR GO; GO:0006256; P:UDP catabolic process; IEA:Ensembl.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 1.
DR Gene3D; 3.30.420.150; Exopolyphosphatase. Domain 2; 1.
DR InterPro; IPR000407; GDA1_CD39_NTPase.
DR PANTHER; PTHR11782; ADENOSINE/GUANOSINE DIPHOSPHATASE; 1.
DR PANTHER; PTHR11782:SF29; ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 4; 1.
DR Pfam; PF01150; GDA1_CD39; 1.
DR PROSITE; PS01238; GDA1_CD39_NTPASE; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Hydrolase {ECO:0000256|RuleBase:RU003833};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|PIRSR:PIRSR600407-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 565..583
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT ACT_SITE 222
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-1"
FT BINDING 274..278
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PIRSR:PIRSR600407-2"
SQ SEQUENCE 617 AA; 70298 MW; 04181DD9D1E191BD CRC64;
MGRISISCLF PASWHFSISP VGCPRILNTN LRQIVVISIL AAAVSLLYFS VVIIRNKYGR
LTRDKKFQRY LARVTDIEAT DTNNPNVNYG VVVDCGSSGS RIFVYCWPRH NGNPHDLLDI
RQMRDKNRKP VVMKIKPGIS EFATSPEKVS DYISPLLNFA AEHVPRAKHK ETPLYILCTA
GMRVLPESQQ KAILEDLLTD IPVHFDFLFS DSHAEVISGK QEGVYAWIGI NFVLGRFEHI
EDDDEAIVEV NIPGSESNEA IIRKRTAGIL DMGGVSTQIA YEVPKTVSFA SSQQEEVAKN
LLAEFNLGCD VHQTEHVYRV YVATFLGFGG NAARQRYEDR IFANTIQKNR LLGKQTGLTP
DTPYLDPCLP LDIKDEIQQN GQTMYLRGTG DFDSCRETIQ PFMNKTNETQ TSLNGVYQPP
IHFLNSEFYG FSEFYYCTED VLRMGGDYNA AKFTKAAKDY CATKWSILRE RFDRGLYASH
ADLHRLKYQC FKSAWMFEVF HRGFSFPVNY KSLKTALQVY DKEVQWTLGA ILYRTRFLPL
RDIQQEAFRA GHAHWRGVSF VYNHYLFSGC FLVVLLSILL YLLRLRRIHR RTPRSGSAAA
ALWMEEGLPS QKLAGTL
//
