ID G1SM55_RABIT Unreviewed; 191 AA.
AC G1SM55;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Ankyrin repeat domain 22 {ECO:0000313|Ensembl:ENSOCUP00000003981.2};
GN Name=ANKRD22 {ECO:0000313|Ensembl:ENSOCUP00000003981.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000003981.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000003981.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000003981.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000003981.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000003981.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02036416; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002718416.2; XM_002718370.3.
DR AlphaFoldDB; G1SM55; -.
DR SMR; G1SM55; -.
DR STRING; 9986.ENSOCUP00000003981; -.
DR PaxDb; 9986-ENSOCUP00000003981; -.
DR Ensembl; ENSOCUT00000004614.4; ENSOCUP00000003981.2; ENSOCUG00000004617.4.
DR GeneID; 100340269; -.
DR KEGG; ocu:100340269; -.
DR CTD; 118932; -.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00390000009005; -.
DR HOGENOM; CLU_121978_0_0_1; -.
DR InParanoid; G1SM55; -.
DR OMA; CINVQDG; -.
DR OrthoDB; 5476252at2759; -.
DR TreeFam; TF332383; -.
DR Proteomes; UP000001811; Chromosome 18.
DR Bgee; ENSOCUG00000004617; Expressed in skin of back and 8 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR042802; ANR22.
DR PANTHER; PTHR47276; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 22; 1.
DR PANTHER; PTHR47276:SF1; ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 22; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13857; Ank_5; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 3.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 39..71
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 134..166
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
SQ SEQUENCE 191 AA; 21994 MW; EF048692A4441397 CRC64;
MGILYSEPIC QAAYQNDFGQ VWRWVREDNH YVNVQDGFNG DTPLICACRR GHTRIVSFLL
KRNANVNLRN QKERTCLHYA VKKRFTFFDY LLIILLMPVL LIGYFLMVSK TKQNEALVRM
LLDAGVEVNA TDCYGYTALH YACEMKNLTL IPLLLGAHAD PTIKNKHGES SLDIAQRLKF
SQIEFMLRKA S
//
