ID G1SNM0_RABIT Unreviewed; 352 AA.
AC G1SNM0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 65.
DE RecName: Full=Cytoplasmic dynein 2 light intermediate chain 1 {ECO:0000256|ARBA:ARBA00018863};
GN Name=DYNC2LI1 {ECO:0000313|Ensembl:ENSOCUP00000004590.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000004590.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000004590.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000004590.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000004590.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000004590.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC {ECO:0000256|ARBA:ARBA00004138}. Cytoplasm, cytoskeleton, cilium
CC axoneme {ECO:0000256|ARBA:ARBA00004430}. Cytoplasm, cytoskeleton,
CC cilium basal body {ECO:0000256|ARBA:ARBA00004120}.
CC -!- SIMILARITY: Belongs to the dynein light intermediate chain family.
CC {ECO:0000256|ARBA:ARBA00006831}.
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DR EMBL; AAGW02006145; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02006146; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SNM0; -.
DR SMR; G1SNM0; -.
DR STRING; 9986.ENSOCUP00000004590; -.
DR PaxDb; 9986-ENSOCUP00000004590; -.
DR Ensembl; ENSOCUT00000005293.4; ENSOCUP00000004590.4; ENSOCUG00000005293.4.
DR eggNOG; KOG3929; Eukaryota.
DR GeneTree; ENSGT00390000010498; -.
DR HOGENOM; CLU_049395_0_0_1; -.
DR InParanoid; G1SNM0; -.
DR TreeFam; TF314138; -.
DR Proteomes; UP000001811; Chromosome 2.
DR Bgee; ENSOCUG00000005293; Expressed in testis and 17 other cell types or tissues.
DR GO; GO:0045177; C:apical part of cell; IEA:Ensembl.
DR GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0036064; C:ciliary basal body; IEA:Ensembl.
DR GO; GO:0035869; C:ciliary transition zone; IEA:Ensembl.
DR GO; GO:0005868; C:cytoplasmic dynein complex; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:Ensembl.
DR GO; GO:0045504; F:dynein heavy chain binding; IEA:Ensembl.
DR GO; GO:0007368; P:determination of left/right symmetry; IEA:Ensembl.
DR GO; GO:0035721; P:intraciliary retrograde transport; IEA:InterPro.
DR GO; GO:0035735; P:intraciliary transport involved in cilium assembly; IEA:Ensembl.
DR GO; GO:1902017; P:regulation of cilium assembly; IEA:Ensembl.
DR InterPro; IPR040045; DYNC2LI1.
DR InterPro; IPR022780; Dynein_light_int_chain.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13236:SF0; CYTOPLASMIC DYNEIN 2 LIGHT INTERMEDIATE CHAIN 1; 1.
DR PANTHER; PTHR13236; DYNEIN 2 LIGHT INTERMEDIATE CHAIN, ISOFORM 2; 1.
DR Pfam; PF05783; DLIC; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT REGION 306..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..352
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 352 AA; 39732 MW; FFA5FE3BD23635AD CRC64;
MPSETLWEIA KAEVEKRGTS GSEHNGVEIG EKSVFFIGSK NGGKTTIILR CLDRDEPPKP
TLALEYTYGR RAKGHNTPKD IAHFWELGGG TSLLDLISIP ITSDTLRTFS IVLVLDLSKP
NDLWPTMENL LQAAKSHVDK VIMKLGKVNS KAASEMRQKI WSNMQKDHPQ DRELIDPFPI
PLVIIGSKYD IFQDFDSEKR KVICKTLRFV AHYYGASLMF TSKSEALLLK IRGVINQLAF
GIDKSKSICV DQNKPLFITA GLDSLSQIGS PPVPDNDIGQ FHAHSPMELW KKVYEKLFPP
KSVNTLKDIK DPARDPQYAE SEVDEMRIQK DQELEQYKKS SSKSWKQIDL ES
//
