ID G1SNU7_RABIT Unreviewed; 405 AA.
AC G1SNU7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 82.
DE SubName: Full=Cyclin E2 {ECO:0000313|Ensembl:ENSOCUP00000004682.4};
GN Name=CCNE2 {ECO:0000313|Ensembl:ENSOCUP00000004682.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000004682.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000004682.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000004682.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000004682.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000004682.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the cyclin family.
CC {ECO:0000256|RuleBase:RU000383}.
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DR EMBL; AAGW02012433; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002710743.1; XM_002710697.3.
DR RefSeq; XP_008253979.1; XM_008255757.2.
DR AlphaFoldDB; G1SNU7; -.
DR SMR; G1SNU7; -.
DR STRING; 9986.ENSOCUP00000004682; -.
DR PaxDb; 9986-ENSOCUP00000004682; -.
DR Ensembl; ENSOCUT00000005398.4; ENSOCUP00000004682.4; ENSOCUG00000005398.4.
DR GeneID; 100134867; -.
DR KEGG; ocu:100134867; -.
DR CTD; 9134; -.
DR eggNOG; KOG0655; Eukaryota.
DR GeneTree; ENSGT00940000156934; -.
DR HOGENOM; CLU_020695_8_0_1; -.
DR InParanoid; G1SNU7; -.
DR OrthoDB; 5474295at2759; -.
DR TreeFam; TF101005; -.
DR Proteomes; UP000001811; Chromosome 3.
DR Bgee; ENSOCUG00000005398; Expressed in testis and 16 other cell types or tissues.
DR GO; GO:0097135; C:cyclin E2-CDK2 complex; IEA:Ensembl.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IEA:Ensembl.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0006270; P:DNA replication initiation; IEA:Ensembl.
DR GO; GO:0007129; P:homologous chromosome pairing at meiosis; IEA:Ensembl.
DR GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl.
DR GO; GO:0032880; P:regulation of protein localization; IEA:Ensembl.
DR GO; GO:0000723; P:telomere maintenance; IEA:Ensembl.
DR CDD; cd20580; CYCLIN_CCNE2_rpt1; 1.
DR CDD; cd20582; CYCLIN_CCNE2_rpt2; 1.
DR Gene3D; 1.10.472.10; Cyclin-like; 2.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like_dom.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR InterPro; IPR048258; Cyclins_cyclin-box.
DR PANTHER; PTHR10177; CYCLINS; 1.
DR PANTHER; PTHR10177:SF70; G1_S-SPECIFIC CYCLIN-E2; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR SMART; SM00385; CYCLIN; 1.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; Cyclin-like; 2.
DR PROSITE; PS00292; CYCLINS; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Cyclin {ECO:0000256|ARBA:ARBA00023127, ECO:0000256|RuleBase:RU000383};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 148..233
FT /note="Cyclin-like"
FT /evidence="ECO:0000259|SMART:SM00385"
FT DOMAIN 242..364
FT /note="Cyclin C-terminal"
FT /evidence="ECO:0000259|SMART:SM01332"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6..30
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..46
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 405 AA; 46632 MW; D2140E73E758F32B CRC64;
MSRRSSRLQA KQQSQPSQTD SPQEAQIIQA KKRKTAQDVK KRKEEKVTKK HQYEIRNCWP
PVLSGGISPC IIIETPHKEI GTSDFSRFTN YRFTNLFINP SPLPDLSWGC SKEVWLNMLK
KESRYVHDKH FEVLHSDLEP QMRSILLDWL LEVCEVYTLH RETFYLAQDF FDRFMLTQKD
INKNMLQLIG ITSLFIASKL EEIYAPKLQE FAYVTDGACS EEDILRMELI ILKALKWELC
PVTVISWLNL FLQVDALKDA PKVLLPQYSQ ETFIQIAQLL DLCVLAVDSL EFQYRILAAA
ALCHFTSIQV VKKASGLEWD NISECVDWMV PFVSVIKSTC PVKLKTFKKI PVEDRHNIQT
HTNYLAMLDE VNYVNSFRKG GQLSPVCSGG IMTPPKSTEK PPGKH
//
