ID G1SPF0_RABIT Unreviewed; 415 AA.
AC G1SPF0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE RecName: Full=TNF receptor-associated factor {ECO:0000256|PIRNR:PIRNR015614};
GN Name=TRAF1 {ECO:0000313|Ensembl:ENSOCUP00000004916.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000004916.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000004916.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000004916.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000004916.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR015614}.
CC -!- SIMILARITY: Belongs to the TNF receptor-associated factor family.
CC {ECO:0000256|PIRNR:PIRNR015614}.
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DR RefSeq; XP_002720548.1; XM_002720502.3.
DR RefSeq; XP_008271598.1; XM_008273376.2.
DR AlphaFoldDB; G1SPF0; -.
DR SMR; G1SPF0; -.
DR STRING; 9986.ENSOCUP00000004916; -.
DR PaxDb; 9986-ENSOCUP00000004916; -.
DR Ensembl; ENSOCUT00000005668.4; ENSOCUP00000004916.3; ENSOCUG00000005668.4.
DR GeneID; 100338847; -.
DR KEGG; ocu:100338847; -.
DR CTD; 7185; -.
DR eggNOG; KOG0297; Eukaryota.
DR GeneTree; ENSGT00940000161076; -.
DR HOGENOM; CLU_021061_0_0_1; -.
DR InParanoid; G1SPF0; -.
DR OMA; CIVETNA; -.
DR OrthoDB; 2913784at2759; -.
DR TreeFam; TF321154; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000005668; Expressed in uterus and 17 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0031996; F:thioesterase binding; IEA:Ensembl.
DR GO; GO:0005164; F:tumor necrosis factor receptor binding; IEA:UniProtKB-UniRule.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0019221; P:cytokine-mediated signaling pathway; IEA:UniProt.
DR GO; GO:2001236; P:regulation of extrinsic apoptotic signaling pathway; IEA:Ensembl.
DR CDD; cd03779; MATH_TRAF1; 1.
DR Gene3D; 1.20.5.110; -; 1.
DR InterPro; IPR002083; MATH/TRAF_dom.
DR InterPro; IPR012227; TNF_rcpt-assoc_TRAF_met.
DR InterPro; IPR008974; TRAF-like.
DR InterPro; IPR037306; TRAF1_MATH.
DR InterPro; IPR032070; TRAF_BIRC3-bd.
DR InterPro; IPR049342; TRAF_MEP1_MATH_dom.
DR PANTHER; PTHR10131; TNF RECEPTOR ASSOCIATED FACTOR; 1.
DR PANTHER; PTHR10131:SF96; TNF RECEPTOR-ASSOCIATED FACTOR 1; 1.
DR Pfam; PF21355; TRAF-mep_MATH; 1.
DR Pfam; PF16673; TRAF_BIRC3_bd; 1.
DR PIRSF; PIRSF015614; TRAF; 2.
DR SMART; SM00061; MATH; 1.
DR SUPFAM; SSF49599; TRAF domain-like; 1.
DR PROSITE; PS50144; MATH; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|PIRNR:PIRNR015614};
KW Metal-binding {ECO:0000256|PIRNR:PIRNR015614};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Zinc {ECO:0000256|PIRNR:PIRNR015614}.
FT DOMAIN 265..411
FT /note="MATH"
FT /evidence="ECO:0000259|PROSITE:PS50144"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 186..262
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 415 AA; 45721 MW; C3A4F9EC72E3689C CRC64;
MASSSASSPR PAPDENEFPF GCPPSAFQDP AEPRALCCTA CLSENLRNCE DRICPACKGD
NPTSVSPGSL RTQEKIHPEV AEAGAGCPFA GVGCSFKGNA QSLQEHEATS QASHLNLLLG
FMKQWKAQLG SGLGSGPMAL ERNLSDLQLQ AAVEVAGDLE VDCYRAPCSE SQEELALQHL
MKEKLLAELE GKLRVFENIV AVLNKEVEAS HLALAASIHQ SQLDRERILS LEQRVVELQQ
TLAQKDQALG KLEQSLRLME EASFDGTFLW KITNVTRRCL ESACGRTVSL FSPAFYTAKY
GYKLCLRLYL NGDGTGKRTH LSLFIVIMRG EYDALLPWPF RNKVTFMLLD QNNREHAIDA
FRPDLSSASF QRPQSETNVA SGCPLFFPLN KLQSPKHAYV KDDTMFLKCI VETSA
//
