ID G1SQG0_RABIT Unreviewed; 210 AA.
AC G1SQG0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE RecName: Full=DNA replication complex GINS protein SLD5 {ECO:0000256|ARBA:ARBA00014804, ECO:0000256|PIRNR:PIRNR007764};
GN Name=GINS4 {ECO:0000313|Ensembl:ENSOCUP00000005333.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000005333.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000005333.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000005333.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000005333.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Required for initiation of chromosomal DNA replication. Core
CC component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that
CC unwinds template DNA during replication, and around which the replisome
CC is built. {ECO:0000256|PIRNR:PIRNR007764}.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|PIRNR:PIRNR007764}.
CC -!- SIMILARITY: Belongs to the GINS4/SLD5 family.
CC {ECO:0000256|ARBA:ARBA00008187, ECO:0000256|PIRNR:PIRNR007764}.
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DR AlphaFoldDB; G1SQG0; -.
DR SMR; G1SQG0; -.
DR STRING; 9986.ENSOCUP00000005333; -.
DR Ensembl; ENSOCUT00000006155.3; ENSOCUP00000005333.3; ENSOCUG00000006154.3.
DR eggNOG; KOG3176; Eukaryota.
DR GeneTree; ENSGT00390000003246; -.
DR HOGENOM; CLU_071893_3_0_1; -.
DR InParanoid; G1SQG0; -.
DR TreeFam; TF105863; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000006154; Expressed in ovary and 15 other cell types or tissues.
DR GO; GO:0071162; C:CMG complex; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0000811; C:GINS complex; IEA:Ensembl.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:Ensembl.
DR GO; GO:0001833; P:inner cell mass cell proliferation; IEA:Ensembl.
DR CDD; cd11711; GINS_A_Sld5; 1.
DR CDD; cd21692; GINS_B_Sld5; 1.
DR Gene3D; 1.20.58.1030; -; 1.
DR Gene3D; 3.40.5.60; -; 1.
DR InterPro; IPR021151; GINS_A.
DR InterPro; IPR036224; GINS_bundle-like_dom_sf.
DR InterPro; IPR008591; GINS_Sld5.
DR InterPro; IPR031633; SLD5_C.
DR InterPro; IPR038749; Sld5_GINS_A.
DR PANTHER; PTHR21206:SF0; DNA REPLICATION COMPLEX GINS PROTEIN SLD5; 1.
DR PANTHER; PTHR21206; SLD5 PROTEIN; 1.
DR Pfam; PF05916; Sld5; 1.
DR Pfam; PF16922; SLD5_C; 1.
DR PIRSF; PIRSF007764; Sld5; 1.
DR SUPFAM; SSF158573; GINS helical bundle-like; 1.
DR SUPFAM; SSF160059; PriA/YqbF domain; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|PIRNR:PIRNR007764};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR007764};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 51..113
FT /note="GINS subunit"
FT /evidence="ECO:0000259|Pfam:PF05916"
FT DOMAIN 152..210
FT /note="DNA replication complex GINS protein SLD5 C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF16922"
SQ SEQUENCE 210 AA; 24223 MW; 87D566B19CBFFA6C CRC64;
MTEELDVLGH DSDGGSDEVI LTPAELIERL EQRFSICQFT PQMELLLVES NLRRAPKGDL
KVSIHRMELE RIRYVLSSYL RCRLTKIEKF FPHILEKEQA RPEGQPSGLS LEELVFAKEY
LANTEAYLRN VALKHMPPNL QKVDLLRAVP KPDLDSYVFL RVKQRQENIL VEPETDEQRD
YVIDLEEGSQ HLIRYKTIAP LVASGAVQLI
//
