ID G1SQL9_RABIT Unreviewed; 1043 AA.
AC G1SQL9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
GN Name=FBH1 {ECO:0000313|Ensembl:ENSOCUP00000005403.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000005403.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000005403.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000005403.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000005403.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
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DR AlphaFoldDB; G1SQL9; -.
DR STRING; 9986.ENSOCUP00000005403; -.
DR PaxDb; 9986-ENSOCUP00000005403; -.
DR Ensembl; ENSOCUT00000006243.3; ENSOCUP00000005403.3; ENSOCUG00000006237.4.
DR eggNOG; KOG2108; Eukaryota.
DR GeneTree; ENSGT00390000011669; -.
DR HOGENOM; CLU_009740_0_0_1; -.
DR InParanoid; G1SQL9; -.
DR TreeFam; TF329020; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000006237; Expressed in ovary and 14 other cell types or tissues.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0019005; C:SCF ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0043138; F:3'-5' DNA helicase activity; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0015616; F:DNA translocase activity; IEA:Ensembl.
DR GO; GO:0003690; F:double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0006308; P:DNA catabolic process; IEA:Ensembl.
DR GO; GO:0006281; P:DNA repair; IEA:Ensembl.
DR GO; GO:2000042; P:negative regulation of double-strand break repair via homologous recombination; IEA:Ensembl.
DR GO; GO:1902231; P:positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; IEA:Ensembl.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:Ensembl.
DR GO; GO:0031297; P:replication fork processing; IEA:Ensembl.
DR GO; GO:0072429; P:response to intra-S DNA damage checkpoint signaling; IEA:Ensembl.
DR CDD; cd22095; F-box_FBXO18; 1.
DR CDD; cd18786; SF1_C; 1.
DR Gene3D; 1.20.1280.50; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR036047; F-box-like_dom_sf.
DR InterPro; IPR001810; F-box_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR11070:SF30; F-BOX DNA HELICASE 1; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF12937; F-box-like; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SMART; SM00256; FBOX; 1.
DR SUPFAM; SSF81383; F-box domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50181; FBOX; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 211..260
FT /note="F-box"
FT /evidence="ECO:0000259|PROSITE:PS50181"
FT REGION 35..56
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 97..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1043 AA; 118261 MW; 1F9A95EBBEC289CE CRC64;
MRRFKRKQLT AIDCQHLAQS HLSVTQPFCQ RWTNRDPNHG LYPRPRTKRG RRGQGCQRHN
SEFFLAGQQQ CTNDMAKSSS VGQDSYQDSE SDMIVPAESS CSLPQRGDRE VRLGSSGSAL
PVRKRSLSFE DENLQATETN QCDGISKKIP RHHVSLSCTR PKEARQEAED RLSCLSAESG
ETDQDIEDIG PDPIPDSYYG LFGTLNCEEA PSHICSLPRE VLRHIFAFLP VEDLYCNLSL
VCHLWREIIS DPLFIPWKKL YHRYLMNEEQ AVSKVDGILL NCGIEKESDL CVLNLIRYTA
TTKCSPSVDP EGALWSLRDH PLRPEAEACV RQHLPDLYVA AGGVNVWALV AAVVLLSSSV
NDIQKLLFCL RRPSSTVTMP DITETLYCIA VLLYAMREKG INISNRIHYN IFYCLYLQEN
SCAQTTRGKE EPSVLPGKKT TIQLTHEQQL ILNHKMEPLQ VVKIMAFAGT GKTSTLVKYA
EKWSESKFLY VTFNKSIAKQ AELVFPSNVI CKTFHSMAYG HVGRKYQLKK KLNLFKLTPF
MVNSVLAEGK GGFIRAKLVC KTLENFFASA DEELTIDHVP IWCKNSQGQR VMVEQSEKLN
GVLEASRLWD NMQKLGECKE EAYQMTHDGY LKLWQLSKPL LASFDAIFVD EAQDCTPAIM
NIVLSQPCGK IFVGDPHQQI YTFRGAVNAL FTVPHTHVFY LTQSFRFGVE IAYVGATILD
VCKRVRKKTL VGGNHQSGIR GDVKGQVALL SRTNANVFDE AVRVTEEVPS RIHLIGGIKS
FGLDRIIDIW ILLQPEEERK KRNLFIKDRF IRRWVHKEGF SGFKRYVTAA EDKELEAKIA
VVEKYNIRIP ELVARIEKCH ILDFAEYILG TVHKAKGLEF DTVHVLDDFV KVPCARHNLA
QLPHFRVESF SEDEWNLLYV AVTRAKKRLI MTKSLENILT LAGEYFLQAE LTSNVLKTGV
VRCCVGQCNN AIPVDTVLTM KKLPITYSNR KENNGGYLCH SCVEQRIGPL AFLTASPEQV
RSMERTVENI VLPRHEALLF LVF
//
