ID G1ST64_RABIT Unreviewed; 630 AA.
AC G1ST64;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Leiomodin 1 {ECO:0000313|Ensembl:ENSOCUP00000006483.3};
GN Name=LMOD1 {ECO:0000313|Ensembl:ENSOCUP00000006483.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000006483.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000006483.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000006483.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000006483.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000006483.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere
CC {ECO:0000256|ARBA:ARBA00004204}.
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DR EMBL; AAGW02025253; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02025254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02025255; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02025256; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1ST64; -.
DR PaxDb; 9986-ENSOCUP00000006483; -.
DR Ensembl; ENSOCUT00000007494.4; ENSOCUP00000006483.3; ENSOCUG00000007492.4.
DR eggNOG; KOG3735; Eukaryota.
DR GeneTree; ENSGT00940000159825; -.
DR HOGENOM; CLU_031052_4_0_1; -.
DR OMA; NQTEKQP; -.
DR TreeFam; TF315841; -.
DR Proteomes; UP000001811; Chromosome 16.
DR Bgee; ENSOCUG00000007492; Expressed in aorta and 16 other cell types or tissues.
DR GO; GO:0030017; C:sarcomere; IEA:UniProtKB-SubCell.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0005523; F:tropomyosin binding; IEA:InterPro.
DR GO; GO:0051694; P:pointed-end actin filament capping; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR004934; TMOD.
DR InterPro; IPR003124; WH2_dom.
DR PANTHER; PTHR10901:SF5; LEIOMODIN-1; 1.
DR PANTHER; PTHR10901; TROPOMODULIN; 1.
DR Pfam; PF03250; Tropomodulin; 1.
DR Pfam; PF02205; WH2; 1.
DR SMART; SM00246; WH2; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS51082; WH2; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 604..623
FT /note="WH2"
FT /evidence="ECO:0000259|PROSITE:PS51082"
FT REGION 69..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 113..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 502..603
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 113..321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..351
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 502..529
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 540..575
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 630 AA; 69289 MW; 339C3AEC81F6E5A9 CRC64;
MLLLPSRTAC CFSLWTPESQ ARGAAHVAKM SKVAKYRRQV SEDPDIDSLL STLSPEEMEE
LEKELDVVDP DGSIPVGLRQ RDQTDKQSTG VYNREAMLNF CEKETKKLIQ REMSVDESKK
VESNADAKNG EERGRDAGTK ALGPRKDPDL GKEPRKGVLK KSVSRDKGDT DGPGGEKPKE
EKLIRGLDKG RVRAAVDKKE GAGEPRAAAS RKEAGDRHLG VSRDKDKKRE EAKEVAKKEE
EEKGKGPSRS PDPRKEGEKL KPRKEDEKPT RPSGGADREK EGEEARRVPG KTDTKKRGEE
GQTEASPAGK EAKDESKTKA PEKQAPTAPP KAAEAPAKAE EEAAPSIFDE PLERVKNNDP
EMTEVNVNNS DCITNEILVR FTEALEFNTV VKVFALANTR ADDHVAFAIA IMLKANKTIT
SLNLDSNHIT GKGILAIFRA LLQNSTLTEL RFHNQRHICG GKTEMEIAKL LKENTTLLKL
GYHFELAGPR MTVTNLLSRN MDKQRQKRLQ EQRQAQEASG EKRELLEVPK AGALAKGSPR
PSPQPSPKPS PKNSPKKGGA PAAPPPPPPP LAPPLIMENL KNSLSPATQR KMGDKVLPAQ
EKNSRDQLLA AIRSSNLKQL KKVEVPKLLQ
//
