ID G1STB2_RABIT Unreviewed; 605 AA.
AC G1STB2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Kelch-like protein 3 {ECO:0000256|ARBA:ARBA00023889};
GN Name=KLHL3 {ECO:0000313|Ensembl:ENSOCUP00000006538.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000006538.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000006538.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000006538.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000006538.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000006538.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}. Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the KLHL3 family.
CC {ECO:0000256|ARBA:ARBA00035639}.
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DR EMBL; AAGW02027790; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02027791; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02027792; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02027793; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02027794; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02027795; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02027796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02027797; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02027798; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1STB2; -.
DR SMR; G1STB2; -.
DR STRING; 9986.ENSOCUP00000006538; -.
DR PaxDb; 9986-ENSOCUP00000006538; -.
DR Ensembl; ENSOCUT00000007561.4; ENSOCUP00000006538.4; ENSOCUG00000007560.4.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00940000157891; -.
DR HOGENOM; CLU_004253_14_2_1; -.
DR InParanoid; G1STB2; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001811; Chromosome 3.
DR Bgee; ENSOCUG00000007560; Expressed in frontal cortex and 14 other cell types or tissues.
DR GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0097602; F:cullin family protein binding; IEA:Ensembl.
DR GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; IEA:Ensembl.
DR GO; GO:0072156; P:distal tubule morphogenesis; IEA:Ensembl.
DR GO; GO:0050801; P:monoatomic ion homeostasis; IEA:Ensembl.
DR GO; GO:0043161; P:proteasome-mediated ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR GO; GO:0070936; P:protein K48-linked ubiquitination; IEA:Ensembl.
DR GO; GO:0070294; P:renal sodium ion absorption; IEA:Ensembl.
DR CDD; cd18513; BACK_KLHL3; 1.
DR CDD; cd18339; BTB_POZ_KLHL3; 1.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR017096; BTB-kelch_protein.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR030578; KLHL3_BACK.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR PANTHER; PTHR24412:SF475; RING CANAL KELCH PROTEIN; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 6.
DR PIRSF; PIRSF037037; Kelch-like_protein_gigaxonin; 1.
DR PRINTS; PR00501; KELCHREPEAT.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00023212};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 68..135
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
SQ SEQUENCE 605 AA; 67308 MW; 252E4224A3E99459 CRC64;
MLDLRTASRL YGFYPDWQRW HLSVKPGSQP PIQAGDDEKN QRTVTVNPAH MGKAFKVMNE
LRSKQLLCDV MIVAEDVEIE AHRVVLAACS PYFCAMFTGD MSESKAKKIE IKDVDGQTLS
KLIDYIYTAE IEVTEENVQV LLPAASLLQL MDVRQNCCDF LQSQLHPTNC LGIRAFADVH
TCTDLLQQAN AYAEQHFPEV MLGEEFLSLS LDQVCSLISS DKLTVSSEEK VFEAVISWIN
YEKETRLEHM AKLMEHVRLP LLPRDYLVQT VEEEVLIKNN NTCKDFLIEA MKYHLLPLDQ
RLLIKNPRTK PRTPVSLPKV MIVVGGQAPK AIRSVECYDF EEDRWDQIAE LPSRRCRAGV
VFMAGHVYAV GGFNGSLRVR TVDVYDGVKD QWTSIASMQE RRSTLGAAVL NDLLYAVGGF
DGSTGLASVE AYSYKTNEWF FVAPMNTRRS SVGVGVVEGK LYAVGGYDGA SRQCLSTVEQ
YDPATNEWIY VADMSTRRSG AGVGVLSGQL YATGGHDGPL VRKSVEVYDP GTNTWKQVAD
MNMCRRNAGV CAVNGLLYVV GGDDGSCNLA SVEYYNPVTD RWTLLPTNMS TGRSYAGVAV
IHKSL
//
