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Database: UniProt
Entry: G1STZ7_RABIT
LinkDB: G1STZ7_RABIT
Original site: G1STZ7_RABIT 
ID   G1STZ7_RABIT            Unreviewed;      2014 AA.
AC   G1STZ7;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   30-AUG-2017, entry version 43.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN5A {ECO:0000313|Ensembl:ENSOCUP00000006803};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000006803, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811};
RG   The Genome Sequencing Platform;
RG   The Genome Assembly Team;
RA   Lindblad-Toh K., Chang J.L., Gnerre S., Clamp M., Lander E.S.;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke inbred {ECO:0000313|Proteomes:UP000001811};
RG   The Genome Sequencing Platform;
RG   The Assembly Computation and Development Core Team;
RA   Di Palma F., Heiman D., Young S., Gnerre S., Johnson J., Lander E.S.,
RA   Lindblad-Toh K.;
RT   "Version 2 of The Genome Sequence of Oryctolagus cuniculus (European
RT   rabbit).";
RL   Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|Ensembl:ENSOCUP00000006803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000006803};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [4] {ECO:0000313|Ensembl:ENSOCUP00000006803}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000006803};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000006803}.
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DR   STRING; 9986.ENSOCUP00000006803; -.
DR   Ensembl; ENSOCUT00000007872; ENSOCUP00000006803; ENSOCUG00000007870.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; G1STZ7; -.
DR   OMA; TWDFCCG; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000001811; Unplaced.
DR   Bgee; ENSOCUG00000007870; -.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR008053; Na_channel_a5su.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PRINTS; PR01666; NACHANNEL5.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    127    151       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    200    220       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    232    249       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    255    275       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    390    418       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    835    858       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    878    895       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    915    938       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1203   1221       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1242   1258       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1270   1290       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1319   1345       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1441   1467       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1643   1672       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1744   1770       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      133    424       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      480    664       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      744    942       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      952   1197       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1201   1475       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1615   1780       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      415    446       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2014 AA;  224477 MW;  85E6271EADFF0994 CRC64;
     MANLLLPRGT GSFRRFTRES LAAIEKRMAE KQARGSAASQ ESRAGLPEEE APRPQLDLQA
     SKKLPDLYGN PPRELIGEPL EDLDPFYSTQ KTFIVLNKGK TIFRFSATNA LYLLSPFHPI
     RRAAVKILVH SCTLFSLLIM CTILTNCVFM AQHDPPPWTK YVEYAFTAIY TFESLVKILA
     RGFCLHAFTF LRDPWNWLDF SVIVMAYTTE FVDLGNVSAL RTFRVLRALK TISVIAGLKT
     IVGALIQSVK KLADVMVLTV FCLSVFALIG LQLFMGNLRH KCVRNFTALN DTNGSVEADG
     LVWNSLDDYL NDPGNYLLKN GTSDVLLCGN SSDAGTCPEG YRCLKAGENP DHGYTSFDSF
     AWAFLALFRL MTQDCWERLY QQTLRSAGKI YMIFFMLVIF LGSFYLVNLI LAVVAMAYEE
     QNQATIAESE EKEKRFQEAM EMLRKEHEAL AIQGVDTVSR SSREMSPLAP VANHERRSKR
     RKVLSSGTEE CGDDRVPKSD SDDGPRALNH LGLPRGPSRS SGRPRSSRGS LFTFRRRDLG
     SEADFADDEN STAGESESHR TSLLVPWPLR RPSTQGQLGP GHALNGKRNS TVDCNGVVSL
     LGTGDAEATS PGSHLRRPGV PERPADTTTP SEEPGGPQVL SPQAPGVDGF EEPGARQRAL
     SAVSVLTSAL EELEESRRKC PPCWNHFAQR CLIWECCPLW LAVKPGKSLS KLAPETDRTV
     HRCHMVELPA GGVNVWKNEA RFETNMEGNN LVFTGIFTAE MTFKIIALDP YYYFQQGWNI
     FDSIIVILSL MELGLSRMGN LSVLRSFRLL RVFKLAKSWP TLNTLIKIIG NSVGALGNLT
     LVLAIIVFIF AVVGMQLFGK NYSEQRHRIS DAGLLPRWHM MDFFHAFLII FRILCGEWIE
     TMWDCMEVSG QSLCLLVFLL VMVIGNLVVL NLFLALLLSS FSADNLTAPD EDGEMNNLQL
     ALARIQRGLR FVRRTARDCC RGLLRRPPKP TALATCGPLP PCVAAPSSPP PPEAEKPPPA
     HKETRFEEGR RPGEGAPGDP EPMCVPIAVA ESDTEDPEEG EDDSLGSEED SSKPESQPVS
     GDPEGPPEPR AWSRVSETAS SEAEASASRA DGWQRRPAEA GAAGCPETHE DSYSEGSTAD
     MTNTADLMEQ IPDLGEDVRD PEDCFTEGCV RRCPCCAVDV TQGPGKVWWR LRKTCYRIVE
     HSWFESFIIF MILLSSGALA FEDIYLEERK AIKALLEYAD KMFTYVFVLE MVLKWVAYGF
     KKYFTSAWCW LDFLIVAVSL VSLVANTLGF SEMGPIKSLR TLRALRPLRA LSRFEGMRVV
     VNALVGAIPS IMNVLLVCLI FWLIFSIMGV NLFAGKFGRC INQTEGDVPL NHTVVNNKSE
     CESFNVTGEL YWTKVKVNFD NVGAGYLALL QVATFKGWMD IMYAAVDSRG YEEQPQWENN
     LYMYIYFVIF IIFGSFFTLN LFIGVIIDNF NQQKKKIRGA RAPLHCPIGA PEEAMKSNAP
     YTFSRHPVHR GQGRHAHFTL PPASIRERGV PATGLLCKYP QRPRSRRSET RSGLPSLASH
     HHCFPGFYTS RKLEQRPRRG SRAPGGGGAV GGRRPQAVLS PAGTVLSDII QKYFFSPTLF
     RVIRLARIGR VLRLIRGAKG IRTLLFALMM SLPALFNIGL LLFLVMFIYA IFGMANFAYV
     KWEAGIDDMF NFQTFANSML CLFQITTSAG WDGLLSPILN TGPPYCDPSL PTGSGSRGNC
     GSPAVGILFF TTYIIISFLI VVNMYIAIIL ENFSVATEES TEPLSEDDFD MFYEIWEKFD
     PEATQFIEYS ALPAFADALS EPLRIAKPNQ LSLISMDLPM VSGDRIHCMD ILFAFTKRVL
     GESGEMDALK IQMEEKFMAA NPSKISYEPI TTTLRRKHEE VSATVIQRAF RRHLLQRSLR
     HASFLFRQRA GSGGLSEEDA PEREGLLART MSEHFARSPG PPCSSSVSST SFSPSYDSVT
     RATSDNLPVR SDCSRSEELA DFLLVSDRDR EFRR
//
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