ID G1SW40_RABIT Unreviewed; 585 AA.
AC G1SW40;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Switching B cell complex subunit SWAP70 {ECO:0000313|Ensembl:ENSOCUP00000007682.2};
GN Name=SWAP70 {ECO:0000313|Ensembl:ENSOCUP00000007682.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000007682.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000007682.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000007682.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000007682.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000007682.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02007894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007895; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007896; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007897; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007898; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02007900; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002708854.1; XM_002708808.3.
DR AlphaFoldDB; G1SW40; -.
DR SMR; G1SW40; -.
DR STRING; 9986.ENSOCUP00000007682; -.
DR PaxDb; 9986-ENSOCUP00000007682; -.
DR Ensembl; ENSOCUT00000008899.4; ENSOCUP00000007682.2; ENSOCUG00000008896.4.
DR GeneID; 100346427; -.
DR KEGG; ocu:100346427; -.
DR CTD; 23075; -.
DR eggNOG; ENOG502QSXX; Eukaryota.
DR GeneTree; ENSGT00950000183017; -.
DR HOGENOM; CLU_029358_1_0_1; -.
DR InParanoid; G1SW40; -.
DR OMA; DYKVNFD; -.
DR OrthoDB; 5354765at2759; -.
DR TreeFam; TF333160; -.
DR Proteomes; UP000001811; Chromosome 1.
DR Bgee; ENSOCUG00000008896; Expressed in autopod skin and 14 other cell types or tissues.
DR GO; GO:0015629; C:actin cytoskeleton; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:Ensembl.
DR GO; GO:0003677; F:DNA binding; IEA:Ensembl.
DR GO; GO:0051017; P:actin filament bundle assembly; IEA:Ensembl.
DR GO; GO:0045190; P:isotype switching; IEA:Ensembl.
DR GO; GO:0030835; P:negative regulation of actin filament depolymerization; IEA:Ensembl.
DR GO; GO:0033633; P:negative regulation of cell-cell adhesion mediated by integrin; IEA:Ensembl.
DR GO; GO:1902309; P:negative regulation of peptidyl-serine dephosphorylation; IEA:Ensembl.
DR GO; GO:0032233; P:positive regulation of actin filament bundle assembly; IEA:Ensembl.
DR GO; GO:0007204; P:positive regulation of cytosolic calcium ion concentration; IEA:Ensembl.
DR GO; GO:0060754; P:positive regulation of mast cell chemotaxis; IEA:Ensembl.
DR GO; GO:0032880; P:regulation of protein localization; IEA:Ensembl.
DR CDD; cd13273; PH_SWAP-70; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR14383; SWAP-70 RECOMBINASE; 1.
DR PANTHER; PTHR14383:SF6; SWITCH-ASSOCIATED PROTEIN 70; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 210..306
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT COILED 316..530
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 585 AA; 69007 MW; C564D2A9A0816C6F CRC64;
MGGLKDELLK AIWHAFTALD LDHSGKVSKS QLKVLSHNLC TVLKVPHDPV ALEEHFRDDD
EGPVSNQGYM PYLNRFILEK VQDNFDKIEF NRMCWTLCVK KNLTKSPLLI TEEDAFKVWV
IFNFLSEDKY PLIIVPEEIE YLLKKLTEAM GGGWQQEQFE HYKINFEDSK DGLSVWELIE
LIGNGQFSKG MDRQTVSMAI NEVFNELILD VLKQGYMMKK GHRRKNWTER WFVLKPNIMS
YYVGEDLKDK KGDIFLDENC CVESLPDKDG KKCLFLIKCF DKTFEISASD KKKKQEWIQA
IHSTIHLLKL GSPPPHKEAR QRRKELRKRL LAEQEELERQ MKELQAANEN KQQELETVRK
KLEEAASRAA EEEKKRLQTQ VELQARFSTE LEREKLIRQQ MEEQVAQKSS ELEQYLQRVR
ELEDMYLKLQ EALEDERQAR QDEETVRKLQ ARLLEEESSK RAELEKWHLE QQQTIQTTEA
EKQELENQRI LKERALQEAM EQLEQLELER KQALEQYEGV KKKLEMATNK TKSWKDKVAH
HEGLIRLIEP GSKNPHLITH WGPAAFTQAE LEEREKNWKG KKTTE
//
