ID G1SXS7_RABIT Unreviewed; 564 AA.
AC G1SXS7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000008377.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000008377.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000008377.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000008377.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000008377.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the ATR family. {ECO:0000256|ARBA:ARBA00008095}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAGW02067573; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02067574; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1SXS7; -.
DR SMR; G1SXS7; -.
DR STRING; 9986.ENSOCUP00000008377; -.
DR PaxDb; 9986-ENSOCUP00000008377; -.
DR Ensembl; ENSOCUT00000009725.3; ENSOCUP00000008377.3; ENSOCUG00000009721.3.
DR eggNOG; ENOG502QSKR; Eukaryota.
DR GeneTree; ENSGT00940000157727; -.
DR HOGENOM; CLU_029760_1_0_1; -.
DR InParanoid; G1SXS7; -.
DR TreeFam; TF328943; -.
DR Proteomes; UP000001811; Chromosome 18.
DR Bgee; ENSOCUG00000009721; Expressed in testis and 1 other cell type or tissue.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd01474; vWA_ATR; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR008400; Anthrax_toxin_rcpt_extracel.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR16059; ANTHRAX TOXIN RECEPTOR; 1.
DR PANTHER; PTHR16059:SF16; ANTHRAX TOXIN RECEPTOR-LIKE; 1.
DR Pfam; PF05587; Anth_Ig; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..29
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 30..564
FT /note="VWFA domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023812948"
FT TRANSMEM 358..377
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 76..247
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 542..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 564 AA; 61961 MW; 1ABC5E9C1DDACFE8 CRC64;
MGGHSPCAPG FPLFFFLLLL LLLPPLVRAG SLPYRGPGWK VFQRLGIGSR LFQHRQGPGG
KPQWRQAEEE CHGSFDLYII LDKSGSVNNN WIDIYVFVEQ LVERFQHPKL RMSFILYSGD
AYTLMPLTSD RDKIREGLEK LQQVIPAGNT NMHEGLKKAN EQIEEANSGD EKVASMIIAM
TDGTLLPMPF ELSKDEAAKA REMGAVIYTV GVKDYNKKQL EAIADRPDYA FGVDNGFKAL
KDIVDSLATQ SCIEVTSMEP STVCVGESSQ VVINGKGFHN AKDQDQVICR FTVEESMVVD
EKPSSMDENV ITCPVPVIDE ANKLIFLEVS LTNGKSFIGN KLNMTSTHCR AGVVSNPIYF
SFLPALLLIP CLLWCCWRLC CRRKVKEPLP LPPPEKEPEE LPPPPPPPPP PPPPINTCPT
VIVSCCGCGC TSGIEGTVDG FCNYIQPSCH SSPIMWCRAR GQARCTNLAL VNSRCAQAPC
SPKVCLRPSR ECFHVPTPCD PQICLQPSQE CFPIPQAPCG SRICLQPTQE CVSLPQLPAT
LQSPSARPLP RQAAEVSGLL PRAT
//
