ID G1SXX2_RABIT Unreviewed; 215 AA.
AC G1SXX2;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Serine and arginine rich splicing factor 6 {ECO:0000313|Ensembl:ENSOCUP00000008429.4};
GN Name=SRSF6 {ECO:0000313|Ensembl:ENSOCUP00000008429.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000008429.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000008429.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000008429.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000008429.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1SXX2; -.
DR SMR; G1SXX2; -.
DR STRING; 9986.ENSOCUP00000008429; -.
DR PaxDb; 9986-ENSOCUP00000008429; -.
DR Ensembl; ENSOCUT00000009785.4; ENSOCUP00000008429.4; ENSOCUG00000009785.4.
DR GeneTree; ENSGT00940000155448; -.
DR HOGENOM; CLU_012062_34_2_1; -.
DR InParanoid; G1SXX2; -.
DR TreeFam; TF351335; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000009785; Expressed in embryo and 14 other cell types or tissues.
DR GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
DR GO; GO:0036002; F:pre-mRNA binding; IEA:Ensembl.
DR GO; GO:0000380; P:alternative mRNA splicing, via spliceosome; IEA:Ensembl.
DR GO; GO:0006376; P:mRNA splice site recognition; IEA:Ensembl.
DR GO; GO:0045617; P:negative regulation of keratinocyte differentiation; IEA:Ensembl.
DR GO; GO:0048025; P:negative regulation of mRNA splicing, via spliceosome; IEA:Ensembl.
DR GO; GO:0060501; P:positive regulation of epithelial cell proliferation involved in lung morphogenesis; IEA:Ensembl.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:Ensembl.
DR GO; GO:0010837; P:regulation of keratinocyte proliferation; IEA:Ensembl.
DR GO; GO:0061041; P:regulation of wound healing; IEA:Ensembl.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR48038; RIBONUCLEOPROTEIN RB97D; 1.
DR PANTHER; PTHR48038:SF1; RIBONUCLEOPROTEIN RB97D; 1.
DR Pfam; PF00076; RRM_1; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00176}.
FT DOMAIN 1..54
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 35..215
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..59
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..120
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 215 AA; 24777 MW; 5B60B91326D613F6 CRC64;
MRQAGEVTYA DAHKERTNEG VIEFRSYSDM KRALDKLDGT EINGRNIRLI EDKPRTSHRR
SYSGSRSRSR SRRRSRSRSR RSSRSRSRSI SKSRSRSRSR SKGRSRSRSK GRKSRSKSKS
KPKSDRGSRS RSRSRSKDEY EKSRSRSRSR SRSPKENGKG DIKSKSRSRS QSRSNSPLPV
PPSKARSVSP PPKRATSRSR SRSRSRSRSR SSSRD
//
