ID G1T1P5_RABIT Unreviewed; 1123 AA.
AC G1T1P5;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=RNA binding motif protein 6 {ECO:0000313|Ensembl:ENSOCUP00000010014.2};
GN Name=RBM6 {ECO:0000313|Ensembl:ENSOCUP00000010014.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000010014.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000010014.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000010014.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000010014.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000010014.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02044104; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02044105; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1T1P5; -.
DR STRING; 9986.ENSOCUP00000010014; -.
DR PaxDb; 9986-ENSOCUP00000010014; -.
DR Ensembl; ENSOCUT00000011644.3; ENSOCUP00000010014.2; ENSOCUG00000011638.3.
DR eggNOG; KOG0154; Eukaryota.
DR GeneTree; ENSGT00940000157976; -.
DR HOGENOM; CLU_291499_0_0_1; -.
DR InParanoid; G1T1P5; -.
DR OMA; REVGSCM; -.
DR TreeFam; TF315789; -.
DR Proteomes; UP000001811; Chromosome 9.
DR Bgee; ENSOCUG00000011638; Expressed in autopod skin and 15 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd12563; RRM2_RBM6; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR Gene3D; 2.160.20.80; E3 ubiquitin-protein ligase SopA; 1.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR041591; OCRE.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR034125; RBM6_RRM2.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR13948; RNA-BINDING PROTEIN; 1.
DR PANTHER; PTHR13948:SF22; RNA-BINDING PROTEIN 6; 1.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF17780; OCRE; 1.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00360; RRM; 2.
DR SUPFAM; SSF141571; Pentapeptide repeat-like; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50174; G_PATCH; 1.
DR PROSITE; PS50102; RRM; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 456..536
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 1051..1097
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT REGION 1..392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 576..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 741..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 815..947
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1004..1109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 976..1003
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 111..134
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..165
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 179..234
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 241..289
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 306..347
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..380
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 576..593
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 594..650
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 742..771
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 772..788
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..864
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 872..886
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1004..1052
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1123 AA; 128442 MW; 9014C0845AE24F30 CRC64;
MWGDSRSANR TGPFRGSQEE RFAPGWNRDY PPPPLKSHAQ ERHSGNFPGR DSLPFDFQGH
SGPPFANVEE HAFSYGARDG PHGDYRGGEG PGHDFRGGDF SSSDFQSRDS SQLDFRGRDI
HSGDFRDREG PPMDYRGGDG TSMDYRGRDT PHMNYRDRDA HTVDFRGRNA PPSDFRGRGT
YDLDFRGRDG SHADFRGRDL PDLDFRPREQ SRSDFRNRDV SDLDFRDKDG TQMDYRGRGS
GTTDLDFRDR DTPHSDFRGR HRSRSDQDFR GREVGPCMEF KDREMPPGDS HILDYIQSST
QDRENSDMNV NKREESTHDH TIERPAFGIQ KGEFEHSETR EGETQGIAFE HESPSDFQNS
QSPTQDQEKS QPSGGEQQSS DAGLFKEEGG LDFLGQQDTD YRSMEYRDVD HRLPGSQIFS
YGQSKSFLEG KTARDAQRDL QDQDYRMGSS EEKPSKLIRL SGVPENSTKE EILNAFRTPD
GRPVKELQLK EYNAGYDYGY VCVEFSLLED AIGCMEANQG TLMIHDKEVT LEYVPGPDFW
YCKRCKSSTG GHRSSCSFYK CPREVTESKQ VLITYPQPQK TSIPASSEKQ PNQLARPADK
ESESRKREEG QESRLGHQKR EAERCLPHSR REGPTFRRDR EKEPWSGDVR QDGESKTIML
KRIYRSTPPE VIVEVLEPYV RLTTANVRII KNRTGPMGHT YGFIDLDSHA EALRVVKILQ
NLDPPFSIDG KMVAVNLATG KRRNDSGDHS DHMHYYQGKK YFRDRRGGGR NSDWSTDTNR
QGQQSSSDCY IYDSATGYYY DPLAGTYYDP TTQQEVYVPQ DPGSPEEEEI KEKKSTSQGK
SSSKKETSKK EGKEKKDRGV TKFQENTSEG KAPQEDVFKK PLPPTVKKEE SPPPPKVVNP
LIGLLGEYGG DSDYEEEEEE EQAPPQQPRT VQPQQREELA KKENEEDKLT DWNKLACLLC
RRQFPNKEVL IKHQQLSDLH KQNLEIHRKI KQSEQELAYL ERREREGRFK ERGNDRREKL
QSFDSPERKR IKYSRETDSD RKPVDKEESD TSSKGGCAQQ ATGWRKGTGL GHGHPGLASS
EETEGRMKGT GVGAPGRTSK RQSNETYRDA VRRVMFARYK ELD
//
