ID G1T1Q6_RABIT Unreviewed; 734 AA.
AC G1T1Q6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Kelch like family member 25 {ECO:0000313|Ensembl:ENSOCUP00000010031.3};
GN Name=KLHL25 {ECO:0000313|Ensembl:ENSOCUP00000010031.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000010031.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000010031.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000010031.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000010031.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1T1Q6; -.
DR SMR; G1T1Q6; -.
DR STRING; 9986.ENSOCUP00000010031; -.
DR PaxDb; 9986-ENSOCUP00000010031; -.
DR Ensembl; ENSOCUT00000011667.3; ENSOCUP00000010031.3; ENSOCUG00000011669.3.
DR eggNOG; KOG4441; Eukaryota.
DR GeneTree; ENSGT00950000182983; -.
DR HOGENOM; CLU_004253_14_6_1; -.
DR InParanoid; G1T1Q6; -.
DR TreeFam; TF329218; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000011669; Expressed in skin of back and 19 other cell types or tissues.
DR GO; GO:0031463; C:Cul3-RING ubiquitin ligase complex; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:1990756; F:ubiquitin ligase-substrate adaptor activity; IEA:Ensembl.
DR GO; GO:0045717; P:negative regulation of fatty acid biosynthetic process; IEA:Ensembl.
DR GO; GO:0032831; P:positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation; IEA:Ensembl.
DR GO; GO:0046321; P:positive regulation of fatty acid oxidation; IEA:Ensembl.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0006446; P:regulation of translational initiation; IEA:Ensembl.
DR GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IEA:Ensembl.
DR Gene3D; 1.25.40.420; -; 1.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 2.
DR InterPro; IPR011705; BACK.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR InterPro; IPR006652; Kelch_1.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR PANTHER; PTHR24412; KELCH PROTEIN; 1.
DR PANTHER; PTHR24412:SF488; KELCH-LIKE PROTEIN 20; 1.
DR Pfam; PF07707; BACK; 1.
DR Pfam; PF00651; BTB; 1.
DR Pfam; PF01344; Kelch_1; 4.
DR SMART; SM00875; BACK; 1.
DR SMART; SM00225; BTB; 1.
DR SMART; SM00612; Kelch; 6.
DR SUPFAM; SSF117281; Kelch motif; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
DR PROSITE; PS50097; BTB; 1.
PE 4: Predicted;
KW Kelch repeat {ECO:0000256|ARBA:ARBA00022441};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 191..259
FT /note="BTB"
FT /evidence="ECO:0000259|PROSITE:PS50097"
FT REGION 98..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 142..161
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 734 AA; 80913 MW; E0837BB3CCE8D0E6 CRC64;
MCLRRGCPMD TVPPCPERGC AGCPSFCIRQ RSDCGSCWEW RLKAQTPPPP PAASRRRCGT
CAFCSPWTCP TRPSHISACP SPSGDCRGFG TGCRPRTAAT AMGPPLESKV PEPLPLQPCP
GAPTEQTVRP GPREPGRPPE QTVGTMSVSV HETRKSRGST GSMNITLFHK ASHPDCVLAH
LNTLRQHRVL TDVTLWAGGR AFPCHRAVLA ASSRYFEAMF SHGLRESRDD TVDFQDNLHP
EVLALLLDFA YSSRIVINEE NAESLLEAGD MLQFPDVRDA AAEFLEKNLL PSNCLRTLLL
ADAHQCRRLH EFSWRMCLLH FETVCRGDDF HGLSKDALLG LISSDELEAQ DERAVLEAVL
QWVKHDLERR RAHLPELLHA VRLALLPSDC LREAAAAEAL LMADERTRLL VDEALRCKTR
ILQNDGVVTS PCARPRKAGH TLLILGGQTF MCDKIYQVDH KAKEIIPKAN LPSPRKEFSA
SAIGCKVYVT GGRGSENGVS KDVWVYDTVH EEWSKAAPML IARFGHGSAE LEHCLYVVGG
HTALAGVFPA SPSVSLKQVE RYDPSANKWV MVAPLRDGVS NAAVVSARLR LFVFGGTSIY
RDMVSKVQCY DPAENRWSIK AECPQPWRYT AAAVLGSQIF IMGGDTEFTA ASAYRFDCES
NQWTRVGDMT AKRMSCHALA SGNKLYVVGG YFGTQRCKTL DCYDPTSDTW SCVTTVPYSL
IPTAFVSTWK HLPA
//
