ID G1T2B9_RABIT Unreviewed; 1598 AA.
AC G1T2B9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Unc-13 homolog B {ECO:0000313|Ensembl:ENSOCUP00000010286.3};
GN Name=UNC13B {ECO:0000313|Ensembl:ENSOCUP00000010286.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000010286.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000010286.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000010286.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000010286.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000010286.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02033497; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02033498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02033499; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02033500; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02033501; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02033502; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02033503; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02033504; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02033505; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02033506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR PaxDb; 9986-ENSOCUP00000010286; -.
DR Ensembl; ENSOCUT00000011960.3; ENSOCUP00000010286.3; ENSOCUG00000011954.4.
DR eggNOG; KOG1011; Eukaryota.
DR GeneTree; ENSGT00940000154929; -.
DR HOGENOM; CLU_001304_3_0_1; -.
DR TreeFam; TF312844; -.
DR Proteomes; UP000001811; Chromosome 1.
DR Bgee; ENSOCUG00000011954; Expressed in prefrontal cortex and 15 other cell types or tissues.
DR GO; GO:0098793; C:presynapse; IEA:UniProt.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0019992; F:diacylglycerol binding; IEA:InterPro.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IEA:UniProt.
DR GO; GO:0016079; P:synaptic vesicle exocytosis; IEA:UniProt.
DR CDD; cd20859; C1_Munc13-2-like; 1.
DR CDD; cd08394; C2A_Munc13; 1.
DR CDD; cd04027; C2B_Munc13; 1.
DR CDD; cd08395; C2C_Munc13; 1.
DR Gene3D; 1.10.357.50; -; 1.
DR Gene3D; 1.20.58.1100; -; 1.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 3.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR010439; MUN_dom.
DR InterPro; IPR014770; Munc13_1.
DR InterPro; IPR014772; Munc13_dom-2.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR027080; Unc-13.
DR InterPro; IPR037302; Unc-13_C2B.
DR PANTHER; PTHR10480; PROTEIN UNC-13 HOMOLOG; 1.
DR PANTHER; PTHR10480:SF8; PROTEIN UNC-13 HOMOLOG B; 1.
DR Pfam; PF00130; C1_1; 1.
DR Pfam; PF00168; C2; 3.
DR Pfam; PF06292; MUN; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00109; C1; 1.
DR SMART; SM00239; C2; 3.
DR SMART; SM01145; DUF1041; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 3.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR PROSITE; PS50004; C2; 3.
DR PROSITE; PS51258; MHD1; 1.
DR PROSITE; PS51259; MHD2; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Exocytosis {ECO:0000256|ARBA:ARBA00022483};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 1..92
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 484..534
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 590..714
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 1020..1163
FT /note="MHD1"
FT /evidence="ECO:0000259|PROSITE:PS51258"
FT DOMAIN 1270..1412
FT /note="MHD2"
FT /evidence="ECO:0000259|PROSITE:PS51259"
FT DOMAIN 1426..1553
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT REGION 183..217
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 234..351
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 234..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..284
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 324..341
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1598 AA; 181413 MW; 14744197B0C7D4CF CRC64;
MTVKRAKFQG SPDKFNTYVT LKVQNVKSTT VAVRGDQPCW EQDFMFEISR LDLGLSVEVW
NKGLIWDTMV GTVWIALKTI RQSDEEGPGE WSTLEAETLM KDDEICGTKN PTPHKILLDT
RFELPFDIPE EEARYWTYKL EQINALGDDD EYSIQEENQR KPLPTAAAQC CHWTYLGWGE
QQTFEDPDSA VDDRDSDYRS ETSNSIPPPY HTTCQPNASV HQFSVPLRLP QQQLLQGGSR
DSCNDSMQSY DLDYPERRAL SPTSSSRYGS SCNVSQGSSQ LSELDQYHEQ DDDRRERDSI
HSYHSSGSLS RDGQAGFGEQ EKALEVTGKA EKGKTCEPKE MNEDATTLPP PDLVLHKDHI
VGPQESFPKE NASSPFTQAR VHWIRAVTKV RLQLQEIPDD GDPSVPQWLP EGPAGGLYGI
DSMPDLRRKK PLPLVSDLSL LQSRKAGISS AMATRTSLKD EELKSHVYKK TLQALIYPIS
CTTPHNFEVW SASTPTYCYE CEGLLWGIAR QGMRCSECGV KCHEKCQDLL NADCLQRAAE
KSSKHGAEDR TQNIIMAMKD RMKIRERNKP EIFEVIRDVF SVSKVAHVQQ MKTVKQSVLD
GTSKWSAKIT ITVVCAQGLQ AKDKTGSSDP YVTVQVGKTK KRTKTIFGNL NPVWEEKFHF
ECHNSSDRIK VRVWDEDDDI KSRVKQRLKR ESDDFLGQTI IEVRTLSGEM DVWYNLEKRT
DKSAVSGAIR LQISVEIKGE EKVAPYHVQY TCLHENLFHY LTDIQGSGGV RISEARGDDA
WKVYFDETAQ EIVDEFAMRY GIESIYQAMT HFACLSSKYM CPGVPAVMST LLANINAYYA
HTTASTNVSA SDRFAASNFG KERFVKLLDQ LHNSLRIDLS TYRNNFPAGS PERLQDLKST
VDLLTSITFF RMKVQELQSP PRASQVVRDC VKACLNSTYE YIFNNCHDLY SHQYQLNQEL
PPEEQGPSIQ NLDFWPKLIT LIVSIIEEDK NSYTPVLNQF PQELNVGKVS AEVMWHLFAQ
DMKYALEEHE KDRLCKSADY MNLHFKVKWL HNEYVRDLPA LQGQVPEYPA WFEQFVLQWL
DENEDVSLEF LRGALERDKK DGFQQTSEHA LFSCSVVDVF TQLNQSFEII RKLECPDPSI
LAHYMRRFAK TIGKVLMQYA DILSKDFPAY CTKEKLPCIL MNNMQQLRVQ LEKMFEAMGG
KELDPEAADS LKELQVKLNT VLDELSMVFG NSFQVRIEEC IRQMADILGQ VRGTGNSSPN
ARASVAQDAD GALRPLMDFL DGNLTLFATV CEKTVLKRVL KELWRVVMNT MERMIVLPPL
TDHTGTQLIF TAAKELSQLS KLKDHMVREE TRSLTPKQCA VLDLALDTIK QYFHAGGNGL
KKAFLEKSPD LQSLRYALSL YTQTTDTLIK TFVRSQIAQG SGVDDPVGEV SIQVDLFTHP
GTGEHKVTVK VVAANDLKWQ TAGMFRPFVE VTMVGPHQND KKRKFTTKSK SNNWAPKYNE
TFHFLLGNEE GPEAYELQIC VKDYCFARED RVLGLAVMPL RDVAAKGSCA CWCPLGRKIH
MDETGVTILR ILSQRSNDEV AREFVKLKSE SRSTEEGS
//
