ID G1T354_RABIT Unreviewed; 956 AA.
AC G1T354;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=Kelch domain containing 4 {ECO:0008006|Google:ProtNLM};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000010641.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000010641.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000010641.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000010641.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1T354; -.
DR SMR; G1T354; -.
DR STRING; 9986.ENSOCUP00000010641; -.
DR Ensembl; ENSOCUT00000012360.4; ENSOCUP00000010641.4; ENSOCUG00000012364.4.
DR eggNOG; KOG1230; Eukaryota.
DR GeneTree; ENSGT00390000003374; -.
DR HOGENOM; CLU_008722_3_1_1; -.
DR InParanoid; G1T354; -.
DR TreeFam; TF323290; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000012364; Expressed in blood and 17 other cell types or tissues.
DR Gene3D; 2.120.10.80; Kelch-type beta propeller; 1.
DR InterPro; IPR015915; Kelch-typ_b-propeller.
DR PANTHER; PTHR46063; KELCH DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46063:SF1; KELCH DOMAIN-CONTAINING PROTEIN 4; 1.
DR Pfam; PF13418; Kelch_4; 2.
DR Pfam; PF13854; Kelch_5; 1.
DR SUPFAM; SSF117281; Kelch motif; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..27
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 28..956
FT /note="Kelch domain containing 4"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023820388"
FT REGION 52..71
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 116..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 157..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 267..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 352..414
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 749..784
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 805..837
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 891..956
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 183..197
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..282
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..393
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 891..926
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 927..942
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 956 AA; 104961 MW; 596A424FE89C23AF CRC64;
VIPNTFTPTF LFLKALFIYL KVRVTHTHTH RERERERERI FHPLVHSPVG SNGRSWADLK
PGASSRPPTR VQGPEDLDHL LLLSQATAES SVGSGAARTR TSAHVGCQHR RWQLSPLSRE
VSGRGSRSPH GWSALGSHFP PRRASALGEA GGLSAVAGGR GASACSAGPA APAPDCPPPA
LHYRVGRRRR HAGSPRHPKA GPRREPGAPS RSPTGRRGPR TAAAAPPGAQ RASSPPRPAC
PARVLTAGGS GCQKAGAAGV KILAGTSSAL SPSPSTQRTA TGRGGREKAG AGGAHRPRPR
SPRPLAPPNP RPEAARGRAG SDAHSARRAV RRAPASGGRA FASFLVAGAA SDPARWARRA
RRRRRAAVRR RRPPRWRRKC PSARGRRRKT WRPSSPTSRL WTPGRPRSWR RRAPRPHHGT
WDVFALANLW RLWSWRQGQC RRERPPGHRR GRLSWGGAWV LNVSYRLNAS LSAHPEKDEL
ILFGGEYFNG QKTLLYNELY VYNTRKDTWT KVDIPSPPPR RCAHQAVVVP QGGGQLWIFG
GEFASPDGEQ FYHYKDLWVL HLANKTWEQV KAPGGPSGRS GHRMVAWKRH LILFGGFHES
ARDYIYYNDV YAFNLDTFTW SKLCPSGTGP SPRSGCQMSI TPQGGIVVYG GYSKQRVKKD
VDHGTQHSDM FLLKPEDGRE GKWTWARIHP SGVKPSPRSG FSVAVAPNQQ TLLFGGVCDE
EEEERLEGDF FNDLHFYDAT RNRWFAGQLK GPKSEKRKRR RGKKEDLAGA CEPESRGASA
PQPLEVVSEV VTEDGTVVTI KQMVAAPGPV GQPQEEDEDG DGAEAAGGPE VGPSPRSHAM
LAVKHGLLYL YGGMFEAGDR QITLGDLYCL DLHRMEEWKV LVDVDPETQE WLEETDSDED
SEEAESADGS DEDENSGEEE EEEEPPHSEV ATERRRGQHA AQRPAEGRSP APCGAR
//
