ID G1T393_RABIT Unreviewed; 894 AA.
AC G1T393;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=GEM interacting protein {ECO:0000313|Ensembl:ENSOCUP00000010686.4};
GN Name=GMIP {ECO:0000313|Ensembl:ENSOCUP00000010686.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000010686.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000010686.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000010686.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000010686.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1T393; -.
DR Ensembl; ENSOCUT00000012414.4; ENSOCUP00000010686.4; ENSOCUG00000012412.4.
DR eggNOG; KOG1453; Eukaryota.
DR GeneTree; ENSGT00950000183110; -.
DR HOGENOM; CLU_006236_1_0_1; -.
DR TreeFam; TF351450; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000012412; Expressed in blood and 17 other cell types or tissues.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR15228:SF16; GEM-INTERACTING PROTEIN; 1.
DR PANTHER; PTHR15228; SPERMATHECAL PHYSIOLOGY VARIANT; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Zinc {ECO:0000256|ARBA:ARBA00022771};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 62..325
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 509..701
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 212..243
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 341..458
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 711..811
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 835..854
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 870..894
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..243
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..447
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 785..799
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 894 AA; 97946 MW; 736B0621CEFFEBF9 CRC64;
MDAAEPGLTP APDGRKRYSD IFRSLDNLEI SLGNVTLLGR GTSEASCWSC PSIESPAPLS
GEELDLRLIR TKGGVDMALD YAKTWSRYAK ELLAWTEKRA NYELEFARSV MKIAEAGKVS
IHQQSHMPLQ YIYTLFLEHD LSLGALAVET VAQQRRDYCQ PLAAKRTEIE KWRKEFKEQW
MKEQKRMNEA VQALRRAQLH YFQRCEDLRA RCQGSPEDPA PQASPGPSKQ QERRRRSREE
AQAKAQEAEA LYQACVREAN ARQQDLEAAK QRIVSHVRKL VLQGDEVLRR VTLGLFGLRG
AQAERAPRAF AALAECCEPF EPGQRYQEYV RALRPEAPPA PPPAFCFQEF APPAHSSPLD
TRKKLSGPPP PRLDESLAEP GAWEDPGAGR QGPAPGSDVD SVGGGSESRS LDSPTSSPGT
RRLVKVSSTG TESSDDFEER DPGEAGSRGR GSGRSPWRLR PTGCGGCGAR PSAASCLLTC
HKRCLETLLI LCGHRKLPAR TPLFGVDFLQ LPRDFPEEVP FVVTKCTAEI EHRALGVQGI
YRVSGSRVRV ERLCQAFENG RALVELSGNS PHDVSSVLKR FLQEVGALGL VVTLHADPGA
DPGAPSPRPE VVYLLKTLLV QLPHSNYNTL RHLVAHLFRV AAHCEENRMS ANNLGIVFGP
TLLRPAEDPR TAGASPATCL LDSGYQAQLV EFLIVHYEQI FGMDELPLAS EPLTQDPSPA
PGPLAITSPC LAPASGPGPE PHPHGSLEKR GEDTTPESPA PPSDQREEVA EDTKDEAEEE
TSQGPEDSFL GTQSRGHFSR QPVKYPRGGV RPVTHQLSSL ALVASKLCEE TPVASVNPGS
LRRRGPSPLC RTPLPKHFEI TQETARLLSK LDSEAVPRTA GSADPQPEED EEHL
//
