ID G1T3N4_RABIT Unreviewed; 386 AA.
AC G1T3N4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 74.
DE SubName: Full=Ankyrin repeat and SOCS box containing 5 {ECO:0000313|Ensembl:ENSOCUP00000010841.4};
GN Name=ASB5 {ECO:0000313|Ensembl:ENSOCUP00000010841.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000010841.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000010841.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000010841.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000010841.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000010841.4};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000256|ARBA:ARBA00005949}.
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DR EMBL; AAGW02011347; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02011348; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1T3N4; -.
DR SMR; G1T3N4; -.
DR Ensembl; ENSOCUT00000012591.4; ENSOCUP00000010841.4; ENSOCUG00000012592.4.
DR GeneTree; ENSGT00940000159851; -.
DR HOGENOM; CLU_000134_4_1_1; -.
DR InParanoid; G1T3N4; -.
DR TreeFam; TF331945; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000001811; Chromosome 2.
DR Bgee; ENSOCUG00000012592; Expressed in skeletal muscle tissue and 13 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03724; SOCS_ASB5; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037328; ASB5_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR24136:SF18; ANKYRIN REPEAT AND SOCS BOX PROTEIN 5; 1.
DR PANTHER; PTHR24136; SOWAH (DROSOPHILA) HOMOLOG; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 4.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS50225; SOCS; 1.
PE 3: Inferred from homology;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 74..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 126..158
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 159..191
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 192..224
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 289..321
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 335..386
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
SQ SEQUENCE 386 AA; 42609 MW; 454194EC6091BE58 CRC64;
MTHWTQSTIA ELVLPLTVTK VYFLKDLGPA VQEHPGREPG TFETWIELKT AADSSAAMSV
LEESRPFAQQ LSNVYFTILS LFCFKLFVKI SLAILSHFYI VKGNRKEAAR IAAEFYGVTQ
GQGSWADRSP LHEAASQGRL LALRTLLSQG YNVNAVTIDH ITPLHEACLG DHVACARTLL
EAGANVNAIT IDGVTPLFNA CSQGSTSCTE LLLEYGAKAQ LESCLPSPTH EAASKGHHEC
LDLLISWGID VDQDIPHLGT PLYVACMSQQ FHCIWKLLYA GADVQKGKYW DTPLHAAAQQ
SSTEIVNLLI EFGADINAKN TELLRPVDVA TTSSMVERIL LQHEATPSSL CQLCRLCIRN
YIGRPRLHLI PQLQLPTLLQ NFLQYR
//