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Database: UniProt
Entry: G1T4K1_RABIT
LinkDB: G1T4K1_RABIT
Original site: G1T4K1_RABIT 
ID   G1T4K1_RABIT            Unreviewed;      2006 AA.
AC   G1T4K1;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   30-AUG-2017, entry version 44.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=SCN3A {ECO:0000313|Ensembl:ENSOCUP00000011209};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000011209, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000011209, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000011209}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000011209};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000011209}.
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DR   EMBL; AAGW02004248; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02004249; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02004250; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02004251; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9986.ENSOCUP00000011209; -.
DR   Ensembl; ENSOCUT00000013019; ENSOCUP00000011209; ENSOCUG00000013003.
DR   eggNOG; ENOG410KCTY; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; G1T4K1; -.
DR   OMA; EGCIKKF; -.
DR   OrthoDB; EOG091G00FK; -.
DR   TreeFam; TF323985; -.
DR   Proteomes; UP000001811; Chromosome 7.
DR   Bgee; ENSOCUG00000013003; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    124    147       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    192    211       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    223    244       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    250    270       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    400    427       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    772    790       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    802    825       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    882    910       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    972    995       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1218   1236       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1257   1276       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1288   1314       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1334   1360       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1455   1479       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1538   1556       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1568   1586       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1593   1618       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1655   1683       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1759   1782       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      127    434       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      507    721       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      772   1000       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1009   1211       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1216   1487       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1537   1792       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      424    465       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2006 AA;  227064 MW;  347C4EE2BCA4A8B3 CRC64;
     MAQTLLVPPG PESFRLFTRE SLAAIEKRAA EEKAKKPKKE QDNDDENKPK PNSDLEAGKN
     LPFIYGDIPP EMVSEPLEDL DSYYINKKTF IVLNKGKAIF RFSATSALYI LTPLNPVRKI
     AIKILVHSLF SMLIMCTILT NCVFMTLSNP PDWTKNVEYT FTGIYTFESL IKILARGFCL
     EDFTFLRDPW NWLDFSVIVM AYVTEFVDLG NVSALRTFRV LRALKTISVI PGLKTIVGAL
     IQSVKKLSDV MILTVFCLSV FALIGLQLFM GNLRNKCLQW PPSDSAFETN TTSYFNSTMD
     SNGTFVNVTT NTFDWKDYIG DDSHFYVLDG QNDPLLCGNG SDAGQCPEGY ICVKAGRNPN
     YGYTSFDTFS WAFLSLFRLM TQDYWENLYQ LTLRAAGKTY MIFFVLVIFL GSFYLVNLIL
     AVVAMAYEEQ NQATLEEAEQ KEAEFQQMLE QLKKQQEEAQ AVAAASAASR DFSGIGGLGE
     LLESSSEASK LSSKSAKEWR NRRKKRRQRE HFEGNSKGEE DRFPKSESED SVKRRSFLFS
     MDGNRLTGDK KFCSPHQSLL SIRGSLFSPR RNSKTSIFSF RGRAKDVGSE NDFADDEHST
     FEDSESRRDS LFVPHRHGER RNSNVSQASM SSRMVPGLPA NGKMHSTVDC NGVVSLVGGP
     SALTSPTGQL QPEVIIDKLA TTDIGTTTET DVRKRRLSSY QISMEMLEDS SGRQRAMSIA
     SILTNTMEEL EESRQKCPPC WYRFANVFLI WDCCEAWLKV KRLVNLIVMD PFVDLAITIC
     IVLNTLFMAM EHYPMTDQFS SVLAVGNLVF TGIFTAEMVL KIIAMDPYYY FQEGWNIFDG
     IIVSLSLMEL GLANVEGLSV LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL
     AIIVFIFAVV GMQLFGKSYK ECVCKISSDC KLPRWHMNDF FHSFLIVFRV LCGEWIETMW
     DCMEVAGQTM CLIVFMLVMV IGNLVVLNLF LALLLSSFSS DNLAATDDDN EMNNLQIAVG
     RMQKGIDYVK DKIQECFRKA FFRKSKVLEI HEGNKIESCI SNNTGIEISK ELNYLKDGNG
     TTSGVGTGSS VEKYVIDEND YMSFINNPSL TVTVPIAVGE SDFENLNTEE FSSESELEES
     KEKLNATSSS EGSTVDVAPP REGEQAEIEP EEDLKPEACF TEGCIKKFPF CQVSTEEGKG
     KIWWNLRKTC YSIVEHNWFE TFIVFMILLS SGALAFEDIY IEQRKTIKTM LEYADKVFTY
     IFILEMLLKW VAYGFQTYFT NAWCWLDFLI VDVSLVSLVA NALGYSELGA IRSLRTLRAL
     RPLRALSRFE GMRVVVNALV GAIPSIMNVL LVCLIFWLIF SIMGVNLFAG KFYHCVNMTT
     GNRFDVKEVN NWSDCQALGN QARWKNVKVN FDNVGAGYLA LLQVATFKGW MDIMYAAVDS
     RDVKLQPVYE ENLYMYLYFV IFIIFGSFFT LNLFIGVIID NFNQQKKKFG GQDIFMTEEQ
     KKYYNAMKKL GSKKPQKPIP RPANKLQGMV FDFVTRQVFD ISIMILICLN MVTMMVETDD
     QSKYMTLVLS RINLVFIVLF TGEFVLKLVS LRYYYFTIGW NIFDFVVVIL SIVGMFLAEL
     IEKYFVSPTL FRVIRLARIG RILRLIKGAK GIRTLLFALM MSLPALFNIG LLLFLVMFIY
     AIFGMSNFAY VKKEAGIDDM FNFETFGNSM ICLFQITTSA GWDGLLAPIL NSAPPDCDPD
     TIHPGSSVKG DCGNPSVGIF FFVSYIIISF LVVVNMYIAV ILENFSVATE ESAEPLSEDD
     FEMFYEVWEK FDPDATQFIE FSKLSDFAAA LDPPLLIAKP NKVQLIAMDL PMVSGDRIHC
     LDILFAFTKR VLGESGEMDA LRIQMEDRFM ASNPSKVSYE PITTTLKRKQ EEVSAAIIQR
     NYRCYLLKQR LKKISSKYDK EAIKGRIDLP IKEDMIIDKL NGNSTPEKTD GSSSTTSPPS
     YDSVTKPDKE KFEKDKTEKE SKGKEV
//
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