ID G1T515_RABIT Unreviewed; 1144 AA.
AC G1T515;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 75.
DE RecName: Full=Structural maintenance of chromosomes protein 5 {ECO:0000256|ARBA:ARBA00018687};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000011406.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000011406.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000011406.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000011406.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000011406.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC5 subfamily.
CC {ECO:0000256|ARBA:ARBA00010171}.
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DR EMBL; AAGW02048621; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02048622; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02048623; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02048624; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1T515; -.
DR SMR; G1T515; -.
DR STRING; 9986.ENSOCUP00000011406; -.
DR PaxDb; 9986-ENSOCUP00000011406; -.
DR Ensembl; ENSOCUT00000013251.4; ENSOCUP00000011406.4; ENSOCUG00000013243.4.
DR eggNOG; KOG0979; Eukaryota.
DR GeneTree; ENSGT01100000263667; -.
DR HOGENOM; CLU_004969_1_0_1; -.
DR InParanoid; G1T515; -.
DR TreeFam; TF105708; -.
DR Proteomes; UP000001811; Chromosome 1.
DR Bgee; ENSOCUG00000013243; Expressed in autopod skin and 15 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0030915; C:Smc5-Smc6 complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR027131; SMC5.
DR PANTHER; PTHR45916; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5; 1.
DR PANTHER; PTHR45916:SF1; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5; 1.
DR Pfam; PF02463; SMC_N; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 95..1095
FT /note="RecF/RecN/SMC N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02463"
FT REGION 1..85
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 278..493
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 694..790
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 932..969
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 29..43
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1144 AA; 133698 MW; B2500C684D2E172B CRC64;
MRRAAARTGS RAGQFAREPG AAAPGAARRW ERKPLRGAEE ARMATSSRKT PTSTPLASKR
ALPRDPSSEV PSKRKNSAPQ PSLLQSAGPF VEGSIVRISM ENFLTYDVCE VSPGPHLNMI
IGANGTGKSS IVCAICLGLA GKPAFMGRAD KVGFFVKRGC SRGMVEIELF RASGNLVITR
EIDVAKNQSF WFINKKSTTQ KIVEEQVAAL NIQVGNLCQF LPQDKVGEFA KLSKIELLEA
TEKSIGPPEM HRYHCELKNF REKEKQLETS CKEKTEYLEK MIQRNERYKQ DVERFYERKR
HLDLIEMLEA KRPWVEYENV RQEYEEVKQA RDRVKEEVRK LKEGQIPMTR RMEEIEKQRH
VLEAQIKEKA TDIKETSQKC KQKQDIIERK DKHIEELQQA LIVKQNEEHD RQRRISNTRK
MIEDLQNELK TAENCENLQP QIDAITNDLR RVQDEKALCE GEIIDKRRER ETLEKEKKNV
DDHIVRFDNL MNQKEDKLRQ RYRDTYDAVL WLRNNRDKFK QRVCEPIMLT INMKDNKNAK
YIENHIPSND LRAFVFESQE DMEVFLKEVR DNKKLRVNAV IAPKNSYAAK APSRSLNELK
QYGFFSYLRE LFDAPDPVMS YLCCQYHIHE VPVGTERTRE RIERVIQETR LKQIYTAEEK
YVVKTSFYSN KLISSNTSLK VAQFLTVTVD LEQRRHLEEQ LKEINRKLQL VESGLSTLRE
TNKHLEHKDN ELRQKKKELL ERKTRKRQLE QKISSKLGSL KLMEQDTCNL EEEERKAATK
IKEINVQKAK LVTELTNLVK ICTSLHIQKV DLILQNTTVI SEKNKLESDY MAASSQLRVT
EQHFVELDEN RQRLLQKCKE LMKRARQVCN LGAEQTVPQE YQTQVPTIPN GHNSSPPMAF
QDLPNTLDEI DALLTEERSR ASCFTGLNPT VVEEYTKREE EIEQLTKELK GKRIELDKYR
ENISQVKERW LNPLKELVEK INEKFSNFFS SMQCAGEVDL HTENEEDYDK YGIRIRVKFR
SSTQLHELTP HHQSGGERSV STMLYLMALQ ELNRCPFRVV DEINQGMDPI NERRVFEMVV
NTACKENTSQ YFFITPKLLQ NLPYSEKMTV LFVYNGPHML EPNRWNLKAF QRRRRRITFT
QPAQ
//
