ID G1T6Y7_RABIT Unreviewed; 712 AA.
AC G1T6Y7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN Name=SLCO2B1 {ECO:0000313|Ensembl:ENSOCUP00000012227.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000012227.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000012227.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000012227.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000012227.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000012227.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362056}.
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DR EMBL; AAGW02008221; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02008222; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02008223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02008224; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02008225; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008262157.1; XM_008263935.2.
DR AlphaFoldDB; G1T6Y7; -.
DR STRING; 9986.ENSOCUP00000012227; -.
DR PaxDb; 9986-ENSOCUP00000012227; -.
DR Ensembl; ENSOCUT00000014225.4; ENSOCUP00000012227.3; ENSOCUG00000014225.4.
DR GeneID; 100353580; -.
DR CTD; 11309; -.
DR eggNOG; KOG3626; Eukaryota.
DR GeneTree; ENSGT01080000257336; -.
DR HOGENOM; CLU_008954_4_2_1; -.
DR InParanoid; G1T6Y7; -.
DR OMA; FMLGSAM; -.
DR OrthoDB; 2874223at2759; -.
DR TreeFam; TF317540; -.
DR Proteomes; UP000001811; Chromosome 1.
DR Bgee; ENSOCUG00000014225; Expressed in liver and 18 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF87; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 2B1; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 86..107
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 114..135
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 182..201
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 222..250
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 270..294
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 369..391
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 403..429
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 441..459
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 558..583
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 595..613
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 650..672
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 480..542
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 682..712
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 712 AA; 77029 MW; A35C66150E533024 CRC64;
MGPRIGPAGE EPPTPDKATM PSEDTAGEDA SPAPRDLRPS VFYNIKFFVL CHSLLQLTQL
MVSGYLKSSI STVEKRFGLS SQTSGLLASF NEVGNTTLIV FVSYFGSRVH RPRLIGCGAV
LVALAGLLMT LPHFLSEPYR YDHSNPEDTP QDVQASLCLP TTPAPALALS NSSCSSYTEN
RHLTMVGIML TAQTLLGVGG VPIQPFGISY IDDFAHHSNS PFYLGILFAV TLMGPGLSFG
LGSLMLRLYV DINRMPEGGI KLTSKDPRWV GAWWLGFLIS AGAVALAAIP YFFFPREMPK
EKRELHFRRK LLTIAASPAS KGEDSPLEQS LGESQKKQDG LAQIATDLTV IQFIKVFPRV
LLRTLRHPIF LLVVLSQVCM SCMAAGMATF LPKFLERQFS ITASYANLLI GSLTIPSAIL
GIVVGGVLIK RLHMGPLRCG ILCLLGALLG LLLTTPLFFT GCSAHRIEGI AQRPAMQPEP
GLFPSCMEAC SCPADGFNPV CDPSTHVEYI TPCHAGCTSQ VVQEATDKSQ PQVLYTNCSC
VEGGGPVLGG SCDSACSYLV LPFMLLVSAG TAAFSITHTP SFMLILRGVK KEDKALAVGI
QFMLLRVLAW MPSPVIHGSA IDTTCVHWAL SCGRQAVCRY YDHDLLRTRF IGLQFFFKTG
TMVCFALVVA ILRQQDKEAR AAATVSGPGS SPGLQQKLLV SEPERKREDS RV
//
