ID G1T7S7_RABIT Unreviewed; 257 AA.
AC G1T7S7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=Potassium channel tetramerization domain containing 1 {ECO:0000313|Ensembl:ENSOCUP00000012578.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000012578.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000012578.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000012578.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000012578.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000012578.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02031837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02031838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02031839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02031840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02031841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017199582.1; XM_017344093.1.
DR RefSeq; XP_017199584.1; XM_017344095.1.
DR AlphaFoldDB; G1T7S7; -.
DR Ensembl; ENSOCUT00000014630.4; ENSOCUP00000012578.3; ENSOCUG00000014635.4.
DR eggNOG; KOG2723; Eukaryota.
DR GeneTree; ENSGT00940000156453; -.
DR HOGENOM; CLU_357861_0_0_1; -.
DR OrthoDB; 2912088at2759; -.
DR TreeFam; TF315332; -.
DR Proteomes; UP000001811; Chromosome 9.
DR Bgee; ENSOCUG00000014635; Expressed in skin of back and 15 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0051260; P:protein homooligomerization; IEA:InterPro.
DR CDD; cd18387; BTB_POZ_KCTD1; 1.
DR InterPro; IPR000210; BTB/POZ_dom.
DR InterPro; IPR048599; BTB_POZ_KCTD1.
DR InterPro; IPR048595; KCTD1-15-like_C.
DR InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR InterPro; IPR003131; T1-type_BTB.
DR PANTHER; PTHR14499:SF65; BTB_POZ DOMAIN-CONTAINING PROTEIN KCTD1; 1.
DR PANTHER; PTHR14499; POTASSIUM CHANNEL TETRAMERIZATION DOMAIN-CONTAINING; 1.
DR Pfam; PF02214; BTB_2; 1.
DR Pfam; PF20871; KCTD1-15_CTD; 1.
DR SMART; SM00225; BTB; 1.
DR SUPFAM; SSF54695; POZ domain; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00022475};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 30..132
FT /note="BTB"
FT /evidence="ECO:0000259|SMART:SM00225"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 257 AA; 29375 MW; 0F73E558392C06A6 CRC64;
MSRPLITRSP ASPLNNQGIP TPAQLTKSNA PVHIDVGGHM YTSSLATLTK YPESRIGRLF
DGTEPIVLDS LKQHYFIDRD GQMFRYILNF LRTSKLLIPD DFKDYTLLYE EAKYFQLQPM
LLEMERWKQD RESGRFARPC ECLVVRVAPD LGERITLSGD KSLIEEVFPE IGDVMCNSVN
AGWNHDSTHV IRFPLNGYCH LNSVQVLERL QQRGFEIVGS CGGGVDSSQF SEYVLRRELR
RTPRVPSVIR IKQEPLD
//
