ID G1T8M9_RABIT Unreviewed; 1457 AA.
AC G1T8M9;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 24-JAN-2024, entry version 75.
DE SubName: Full=Leucine rich pentatricopeptide repeat containing {ECO:0000313|Ensembl:ENSOCUP00000012939.3};
GN Name=LRPPRC {ECO:0000313|Ensembl:ENSOCUP00000012939.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000012939.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000012939.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000012939.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000012939.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000012939.3};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; AAGW02006150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02006151; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02006152; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9986.ENSOCUP00000012939; -.
DR PaxDb; 9986-ENSOCUP00000012939; -.
DR Ensembl; ENSOCUT00000015057.4; ENSOCUP00000012939.3; ENSOCUG00000015046.4.
DR eggNOG; KOG4318; Eukaryota.
DR GeneTree; ENSGT00960000186682; -.
DR HOGENOM; CLU_006166_0_0_1; -.
DR InParanoid; G1T8M9; -.
DR OMA; HIDRNKI; -.
DR TreeFam; TF323626; -.
DR Proteomes; UP000001811; Chromosome 2.
DR Bgee; ENSOCUG00000015046; Expressed in skeletal muscle tissue and 16 other cell types or tissues.
DR GO; GO:0000794; C:condensed nuclear chromosome; IEA:Ensembl.
DR GO; GO:0005874; C:microtubule; IEA:Ensembl.
DR GO; GO:0042645; C:mitochondrial nucleoid; IEA:Ensembl.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:Ensembl.
DR GO; GO:0048487; F:beta-tubulin binding; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; IEA:Ensembl.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IEA:Ensembl.
DR GO; GO:0000957; P:mitochondrial RNA catabolic process; IEA:Ensembl.
DR GO; GO:0000961; P:negative regulation of mitochondrial RNA catabolic process; IEA:Ensembl.
DR GO; GO:0070129; P:regulation of mitochondrial translation; IEA:Ensembl.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR InterPro; IPR033490; LRP130.
DR InterPro; IPR002885; Pentatricopeptide_rpt.
DR InterPro; IPR033443; PPR_long.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR NCBIfam; TIGR00756; PPR; 2.
DR PANTHER; PTHR46669; LEUCINE-RICH PPR MOTIF-CONTAINING PROTEIN, MITOCHONDRIAL; 1.
DR PANTHER; PTHR46669:SF1; LEUCINE-RICH PPR MOTIF-CONTAINING PROTEIN, MITOCHONDRIAL; 1.
DR Pfam; PF01535; PPR; 3.
DR Pfam; PF13812; PPR_3; 1.
DR Pfam; PF17177; PPR_long; 1.
DR PROSITE; PS51375; PPR; 4.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT REPEAT 260..294
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT DOMAIN 286..393
FT /note="Pentacotripeptide-repeat region of PRORP"
FT /evidence="ECO:0000259|Pfam:PF17177"
FT REPEAT 295..329
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REPEAT 811..845
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
FT REPEAT 1018..1052
FT /note="PPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00708"
SQ SEQUENCE 1457 AA; 164283 MW; ACD87A7B39FD3F35 CRC64;
MPNRANYFFT QIGFPVLQSQ TTTASPYAWR AGSLVRPAPV DPAVTCSSCP SEERASRRGD
SQAMAALLRP ARWLLRAGRA ARLPLSLRLL AGCSGLPHAV PCLPAARSGP IAGGLLSQAR
LYAIAAEKKN VLQEEPTLSP KRNARWFDWA LMRLDNSVRR TGRIPKMLLQ RVFDSTCHSG
SPGSNQALLL LRSCGSLLPE LTLAERTEFA HQIWEKLQKL GTVYDVSHYN ALLKVYLQNE
YKFSPTDFLA KMEEANIQPN RVTYQRLIAA YCNVGDIEGA SKILGFMKTK DLPVTEAVFS
ALVTGHARAG DMENAENILT VMKEAGIEPG PDTYLALLNA YAEKGDIDRV KQTLEKVEKS
DLYLMDRDLL QIIFSFSKAG YPQYVSEILE KITYERRYIP DAMNLILLLV TEKLEDTALQ
ILLACPISKE DNLTDFGSFF LKHCVTVDTP VDKLIDYCKK LKEAQMHSSP LQFTLHCALV
ANKTDLAKAL MKTLKEEGFP VRTHYFWPLL VGYQKKKNVQ GIIEVLKGMH EMGVVPDQET
YINYVFPSFD NVQSVRAVLQ ENGCLPESDT FSLAEVRHEA LNGNLAYILS FLESNTTPFP
FNYLRGSLIL GFRRSMDVNL WGKITELLYK DGRYCQEPPG PTEAVGYFLY NLIDSMSDSE
VQAKEELLRQ YFHQLKEMNV KIPDNIYRGI RNLLDSYHVP ELIKDVNLLV EREKIDSQKT
FQPASSDLES TLEKLKAQNQ PIGDVLKQLI LVLCSKENMQ KALELKAKYE SDMVLGGYAA
LINLCCRHDN AEDALNLKQE FDRLDSSAVL DTNKYVGLVR VLGKHGKLQD AINILKEMKE
KDVLIKDATV LSFFHILNGA ALRGEIETVK QLHEAIVTLG LAKPSTNISS PLVTVYLEKD
NLAAALEVAM DCYRKYQILP RIHDILCKLI EKGETDLIQK AMDFVSQEQG EMTMLYDLFF
AFLQTGNYKE AKKIIETPGI RARPARLQWF CERCISSNQV ETLEKLVELT QKLFECDRDQ
MYYSLLKLYK INGNWQKADA VWNKMQEENV IPREKTLRLL ADILRNSNQE VPFDVPELWC
EDEAGSLSSS SPSPLETDIQ KHVLKACQMK RNKDAYNIFL KAERQNIVFN SETYNSLIKL
LLSNNGFIQA MQVKDFAETH IKGFTLNDAA NSLLIITQVR RDYLKEALRT LKAALDLGQT
PSRLAVTRLI QAFALKGDVQ SIEAIQKMVH GLDSIGLSRM VFINNIALAQ IKNNNVDVVV
ENIENMLTSG TPTVEPQFFG LAYLFRKVIE EQLDPAAEKL SIMAERLANQ FAVYKPVTDF
FLQLVDAGKT DDARALLQRC GAIAEQTPIL LVFCIRSSQK PGKAPTLKSL LELIPELTEK
EEAYTSAMKS YVLDKDVASA KALYEHLTAK KTKLNDLFLK RYAVLLKGAG ESVPFPEPPE
SFEFYANQLK ESKEKPL
//