ID G1T9B7_RABIT Unreviewed; 664 AA.
AC G1T9B7;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Leucine rich repeat containing 32 {ECO:0000313|Ensembl:ENSOCUP00000013219.3};
GN Name=LRRC32 {ECO:0000313|Ensembl:ENSOCUP00000013219.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000013219.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000013219.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000013219.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000013219.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000013219.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
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DR EMBL; AAGW02008253; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008261952.1; XM_008263730.2.
DR AlphaFoldDB; G1T9B7; -.
DR SMR; G1T9B7; -.
DR STRING; 9986.ENSOCUP00000013219; -.
DR Ensembl; ENSOCUT00000015385.3; ENSOCUP00000013219.3; ENSOCUG00000015394.3.
DR GeneID; 100353075; -.
DR KEGG; ocu:100353075; -.
DR CTD; 2615; -.
DR eggNOG; KOG0619; Eukaryota.
DR GeneTree; ENSGT00940000162288; -.
DR HOGENOM; CLU_024194_1_0_1; -.
DR InParanoid; G1T9B7; -.
DR OrthoDB; 3449906at2759; -.
DR TreeFam; TF317167; -.
DR Proteomes; UP000001811; Chromosome 1.
DR Bgee; ENSOCUG00000015394; Expressed in ovary and 18 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0050431; F:transforming growth factor beta binding; IEA:Ensembl.
DR GO; GO:0046007; P:negative regulation of activated T cell proliferation; IEA:Ensembl.
DR GO; GO:0001818; P:negative regulation of cytokine production; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:1901398; P:regulation of transforming growth factor beta3 activation; IEA:Ensembl.
DR GO; GO:0062009; P:secondary palate development; IEA:Ensembl.
DR GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR24373; SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN; 1.
DR PANTHER; PTHR24373:SF275; VASORIN; 1.
DR Pfam; PF13855; LRR_8; 5.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 6.
DR SMART; SM00368; LRR_RI; 3.
DR SMART; SM00369; LRR_TYP; 16.
DR SUPFAM; SSF52058; L domain-like; 2.
DR PROSITE; PS51450; LRR; 4.
PE 4: Predicted;
KW Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Proteoglycan {ECO:0000256|ARBA:ARBA00022974};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022530}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..664
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023904053"
FT TRANSMEM 630..653
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 282..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 664 AA; 71341 MW; 1C0A4E45BA242959 CRC64;
MSPQMLLLLT VLSPALATSQ HRLKVPCKMV GKEALCQGLG LLQVPAMLLA DIETLDLSGN
QLRSVLASPL DFYTSLRHLD LSANEISFLQ PGVFQALPQL QHLNLAHNRL AAGTVLSAGS
LSPLPHVTSL DLSGNSLYSG LLEQLLGEAP HLHSLSLAEN SLTRLGRRTF RGLPALERLD
LHSNVLMDIE DGAFEALPRL AHLNLSRNSL TCISDFSLPQ LQVLDLSCNS IEAFQTAPEP
PAEYQLTWLD LRENRLLQLP DLAALPKLLY LNMSNNLIRL PAGPPQGGEA SPAPSQGWPA
WPPGGSPGWN ASSQPLSQLL NLDLSYNEIE LVPGGFLEHL ASLRFLNLSR NCLRAFEAGH
AGSLPLLVLL DLSHNALEAL ELGARALGSL RTLLLQDNAL RSLPPYTFAG LASLQRLNLQ
GNRVSPCGGP AEPAPPGCVA FSGISSLRVL NLVDNEMGTL RAGAFLRTPL TELDLSANPG
LEVATGALAG LEASLEVLAL QGNGLAVLQV DLPCFSCLKR LNLAGNRLSH LPAWTQAVSL
EVLDLRNNSF SLLPGSAMGG LEPSLRRLYL QGNPLSCCGN GWLAAQLHQG RVDVDATQGL
ICRFGSQEEV SLSHVRPEDC EKGGLKNVNL IIILTFTLLL AIVLTTLATC CCVRRQRFNQ
QYKA
//
