ID G1TAL8_RABIT Unreviewed; 870 AA.
AC G1TAL8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Ankyrin repeat and KH domain containing 1 {ECO:0000313|Ensembl:ENSOCUP00000013725.4};
GN Name=ANKHD1 {ECO:0000313|Ensembl:ENSOCUP00000013725.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000013725.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000013725.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000013725.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000013725.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000013725.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02027695; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02027696; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02027697; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02027698; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02027699; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1TAL8; -.
DR Ensembl; ENSOCUT00000015968.4; ENSOCUP00000013725.4; ENSOCUG00000015943.4.
DR GeneTree; ENSGT00940000153768; -.
DR HOGENOM; CLU_000590_0_1_1; -.
DR Proteomes; UP000001811; Chromosome 3.
DR Bgee; ENSOCUG00000015943; Expressed in autopod skin and 14 other cell types or tissues.
DR ExpressionAtlas; G1TAL8; baseline.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR CDD; cd22503; KH-I_ANKHD1; 1.
DR Gene3D; 3.30.1370.10; K Homology domain, type 1; 1.
DR InterPro; IPR047374; KH-I_ANKHD1.
DR InterPro; IPR004087; KH_dom.
DR InterPro; IPR004088; KH_dom_type_1.
DR InterPro; IPR036612; KH_dom_type_1_sf.
DR PANTHER; PTHR23206:SF5; ANKYRIN REPEAT AND KH DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23206; MASK PROTEIN; 1.
DR Pfam; PF00013; KH_1; 1.
DR SMART; SM00322; KH; 1.
DR SUPFAM; SSF54791; Eukaryotic type KH-domain (KH-domain type I); 1.
DR PROSITE; PS50084; KH_TYPE_1; 1.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00117}.
FT DOMAIN 80..150
FT /note="K Homology"
FT /evidence="ECO:0000259|SMART:SM00322"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 274..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 647..695
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 374..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..684
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 870 AA; 92019 MW; 8A71D267B3CF692A CRC64;
MDVNSSNDRR YPPLLLHSQE EKTSSTTSKT QTRLEGEVNS NSLSSSYKSV SLPLSSPNIK
LNLTSPKRGQ KREEGWKEVV RRSKKLSVPA SVVSRIMGRG GCNITAIQDV TGAHIDVDKQ
KDKNGERMIT IRGGTESTRY AVQLINALIQ DPAKELEDLI PKNHIRTPAN NKSIHANFSS
GVGTTTASSK NTFPLGAPTL VTSQGTTLST FQPTNKLSKN VATNVRSSFP VSLPLAYPHP
HFALLAAQTM QQIRHPRLPM AQFGGTFSPS ANTWGPFPVR PVNPSNTNSS PKHNNTSNRL
PNQNGTVLPS ESPGLTTASC PITVSSVVAA SQQLCVTNTR TPSSVRKQLF ACVPKTSPPT
TVISSVTSTC SSLPSVSSAS ITSGQVPTTF LPTSTPQAQL SSQKMESFST VPSPKEKVSA
QDQPMANLCT PSPTTNSCSS SASNTPGAPE THPSSSPTPT SSNTQEEAQP SSASDLSPMS
IPFASNSEPA PLTLTSPRLV SADNQDTSNL PQLTIPAPRV SHRMQPRGSF YSVVPNAAIH
QDPQSIFVTN PVPLTPPQGP PATVQLSSAV NIMNGSQMHI NPANKSLPPA FGPATLFNHF
SSLFDSSQVP ANQGWGDGPL SSRVAADASF TVQSAFLGNS VLGHLENVHP DNSKAPGFRP
PSQRVSTSPA ATSAAPTLGQ AKGGSASQDR KIPPPIGTER LARIRQGGSV AQAPMGTSFV
APVGHSGIWS FGVNAVSEGL SGWSQSVIGN HPMHQQLSDP STFSQHQPME RDDSGMVAPS
NIFHQPMASG FVDFSKGLPI SMYGGALIPS HPQLADVPGG PLFNGLHNPD PAWNPMIKVI
QNSAECTEAQ QIWPGTWAPH IGNMHLKYVN
//
