ID G1TAS8_RABIT Unreviewed; 985 AA.
AC G1TAS8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 76.
DE SubName: Full=RAB44, member RAS oncogene family {ECO:0000313|Ensembl:ENSOCUP00000013796.4};
GN Name=RAB44 {ECO:0000313|Ensembl:ENSOCUP00000013796.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000013796.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000013796.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000013796.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000013796.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000013796.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Apical cell membrane
CC {ECO:0000256|ARBA:ARBA00004221}.
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DR EMBL; AAGW02017838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_017200566.1; XM_017345077.1.
DR AlphaFoldDB; G1TAS8; -.
DR SMR; G1TAS8; -.
DR STRING; 9986.ENSOCUP00000013796; -.
DR PaxDb; 9986-ENSOCUP00000013796; -.
DR Ensembl; ENSOCUT00000016049.4; ENSOCUP00000013796.4; ENSOCUG00000016053.4.
DR GeneID; 100341179; -.
DR KEGG; ocu:100341179; -.
DR CTD; 401258; -.
DR eggNOG; KOG0078; Eukaryota.
DR GeneTree; ENSGT00940000160379; -.
DR HOGENOM; CLU_012405_0_0_1; -.
DR InParanoid; G1TAS8; -.
DR OrthoDB; 5310663at2759; -.
DR TreeFam; TF313199; -.
DR Proteomes; UP000001811; Chromosome 12.
DR Bgee; ENSOCUG00000016053; Expressed in blood and 2 other cell types or tissues.
DR GO; GO:0016324; C:apical plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0002553; P:histamine secretion by mast cell; IEA:Ensembl.
DR GO; GO:0097279; P:histamine secretion mediated by IgE immunoglobulin; IEA:Ensembl.
DR CDD; cd00154; Rab; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR025662; Sigma_54_int_dom_ATP-bd_1.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR47977; RAS-RELATED PROTEIN RAB; 1.
DR PANTHER; PTHR47977:SF72; RAS-RELATED PROTEIN RAB-44; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
DR PROSITE; PS00675; SIGMA54_INTERACT_1; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 77..112
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 1..40
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 318..405
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 446..788
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 191..247
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 698..718
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 985 AA; 106227 MW; 4CEF37E93511D276 CRC64;
MESGQRVSRR GRKLGSSRRR QMREPADGQD APVAPEPLSW SAQTQEELQD FFQDCGARER
GFVTRQDLEA AKFSFLGSED ELEMIFDWVD VERKGRLSLE EFSSGLKNIF GSSLCTHRLR
RRRPRPTKRL PTATSFLELE EADAEEREAF LTFTEQLGTG PFLPEQAEIW QLWKKLRQEE
PQLAGNLEGF LARMSSRLQE VQASKEALEL TLRKRDSDHH REVQRLYEEM EQQIVRERQQ
LQAESDSRGL ALSSQVHDVL AAKELKAQQL AAGHRELEAH LQRLSSTQQE ASAENLQLRE
AQRDLAGQLE EVRGQLRATR GRLASARARV SWQTEEEPSV PSTREKVPDP PATAPEEAPL
PELVGDNDDW DQLLSGFRSP PRGALQLTWS PPPTPRAASG PQTPRVVRQI SISEPQALPS
AQEPAAHSDG APSLLPGVIA LAKGREGVER SGRDIGPEPP VQAQSLEPTL KPGPPAEAHF
LYDPPGAPGE ESQSLGAAAL RMLMPLEGEP PPQESAPPPQ ALAGPNKQSQ VPGPRPQGPG
LRSAAAELPR LGAARSRDLP DTGSESSAGS LGALALPLGS AEPSQGLEPV SLAPAEGLEQ
GQLNPAGQEG PPGGPQDARG QGPGPNGWPA LPHQGLEEEP REEEEEIKEV GGGSRSPGSV
QALEAPGLPP GPGEQTQERA LPAPLPLHAA PARAGTEAPG PGKPPPASGP PPTALPGATG
GPQGPTQTFP SVPEPGAQPR PPATNAHQEG RPGFPGSQEA RAEGRPGDPG MDSGEAGRPL
TRGDHRPGEP PVCPDYVFHV IFLGDSGVGK TSFLHLLHHN SFASGPTATV GVDFRVKTLL
VDNKWFALQL WDTAGQERYH SLTRQLLRKA DGVVLMYDVT CQSSFARVRY WLHCLQDAGA
DEVAILLLGN KTDCEEVRQV PTEAGRHLAQ ELGVSFGECS AALGHNILEP MVSLARSLRV
QEDRLKRSLV DMVPKRPPKR AGCCS
//
