ID G1TB02_RABIT Unreviewed; 1464 AA.
AC G1TB02;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 82.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRM {ECO:0000313|Ensembl:ENSOCUP00000013875.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000013875.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000013875.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000013875.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000013875.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000013875.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 2B subfamily. {ECO:0000256|ARBA:ARBA00006396}.
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DR EMBL; AAGW02031471; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02031472; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02031473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02031474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02031475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02031476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02031477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02031478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02031479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02031480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008259278.1; XM_008261056.2.
DR PaxDb; 9986-ENSOCUP00000013875; -.
DR Ensembl; ENSOCUT00000016145.4; ENSOCUP00000013875.4; ENSOCUG00000016125.4.
DR eggNOG; KOG4228; Eukaryota.
DR GeneTree; ENSGT00940000155020; -.
DR HOGENOM; CLU_001645_0_1_1; -.
DR OrthoDB; 2875525at2759; -.
DR TreeFam; TF312900; -.
DR Proteomes; UP000001811; Chromosome 9.
DR Bgee; ENSOCUG00000016125; Expressed in upper lobe of left lung and 15 other cell types or tissues.
DR GO; GO:0005912; C:adherens junction; ISS:UniProtKB.
DR GO; GO:0030027; C:lamellipodium; ISS:UniProtKB.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
DR GO; GO:0045296; F:cadherin binding; ISS:UniProtKB.
DR GO; GO:0005001; F:transmembrane receptor protein tyrosine phosphatase activity; ISS:UniProtKB.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; ISS:UniProtKB.
DR GO; GO:0016525; P:negative regulation of angiogenesis; ISS:UniProtKB.
DR GO; GO:0010596; P:negative regulation of endothelial cell migration; ISS:UniProtKB.
DR GO; GO:0001937; P:negative regulation of endothelial cell proliferation; ISS:UniProtKB.
DR GO; GO:0031175; P:neuron projection development; ISS:UniProtKB.
DR GO; GO:0006470; P:protein dephosphorylation; ISS:UniProtKB.
DR GO; GO:0009410; P:response to xenobiotic stimulus; ISS:UniProtKB.
DR GO; GO:0010842; P:retina layer formation; ISS:UniProtKB.
DR GO; GO:0031290; P:retinal ganglion cell axon guidance; ISS:UniProtKB.
DR GO; GO:0007165; P:signal transduction; ISS:UniProtKB.
DR CDD; cd00063; FN3; 3.
DR CDD; cd06263; MAM; 1.
DR CDD; cd14633; R-PTPc-M-1; 1.
DR CDD; cd14635; R-PTPc-M-2; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR000998; MAM_dom.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR045911; R-PTP-mu_cat_rpt1.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR24051:SF12; PROTEIN TYROSINE PHOSPHATASE, RECEPTOR TYPE, M; 1.
DR PANTHER; PTHR24051; SUSHI DOMAIN-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 2.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF00629; MAM; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00020; MAMDOMAIN.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 4.
DR SMART; SM00409; IG; 1.
DR SMART; SM00137; MAM; 1.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00740; MAM_1; 1.
DR PROSITE; PS50060; MAM_2; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..1464
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023938220"
FT TRANSMEM 742..763
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 24..183
FT /note="MAM"
FT /evidence="ECO:0000259|PROSITE:PS50060"
FT DOMAIN 185..276
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 283..378
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 381..479
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 481..586
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 912..1166
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1083..1157
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1198..1460
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1374..1451
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1464 AA; 164959 MW; B1802C8435385AD6 CRC64;
MRLGTCLATL AGLLLTAAGD TFSGGCLFDE PYSTCGYSQA EDDDFNWEQV NTLTKPTSDP
WMPSGSFMLV NTSGRPEQQT AHLLLPQLKE NDTHCIDFHY FVSSKSNSAP GLLNVYVRVN
NGPLGNPIWN ISGDPTRTWN RAELAISTFW PNFYQVIFEV VTSGHQGYLA IDEVKVLGHP
CTRTPHFLRI QNVEVNAGQF ATFQCSAIGR TVAGDRLWLQ GIDVRDAPLK EIKVTSSRRF
IASFNVVNTT KRDAGKYRCM IRTEGGVGIS NYAELVVKEP PVPIAPPQLA SVGATYLWIQ
LNANSINGDG PIVAREVEYC TASGSWNDRQ PVDSTSYKIG HLDPDTEYEI SVLLTRPGEG
GTGSPGPALR TRTKCADPMR GPRKLEVVEV KSRQITIRWE PFGYNVTRCH SYNLTVHYCY
QVGGQEQVRE EVSWDPDNSH PQHTITNLSP YTNVSVKLIL MNPEGRKESQ ALVVQTDEDL
PGAVPTESIQ GSTFEEKIFL QWREPTQTYG VITLYEITYK AVSSFDPEID LSNQSGRVSK
LGNETHFLFF GLYPGTTYSF TIRASTAKGF GPPATNQFTT KISAPSMPAY ELETPLNQTD
NTVTVMLKPA QSRGAPVSVY QIVVEEERPR RTKKTTEVLK CYPVPIHFQN ASILNSQYYF
AAEFPADSLQ AAQPFTVGDN KTYSGYWNTP LLPHKSYRIY FQAASRANGE TKIDCVRVAT
KGAATPKPVP EPEKQTDHTV KIAGVIAGIL LFVIIFLGVV LVMKKRKLAK KRKETMSSTR
QEMTVMVNSM DKSYAEQGTN CDEAFSFMDT HNLNGRSVSS PSSFTMKTNT LSTSVPNSYY
PDPFVPTAIL VPINDETHTM ASDTSSLVQS HTYKKREQTD VPYQTGQLHP AIRVADLLQH
ITQMKCAEGY GFKEEYESFF EGQSAPWDSA KKDENRMKNR YGNIIAYDHS RVRLQTIEGD
TNSDYINGNY IDGYHRPNHY IATQGPMQET IYDFWRMVWH ENTASIIMVT NLVEVGRVKC
CKYWPDDTEI YKDIKVTLIE TELLAEYVIR TFAVEKRGVH EIREIRQFHF TGWPDHGVPY
HATGLLGFVR QVKSKSPPNA GPLVVHCSAG AGRTGCFIVI DIMLDMAERE GVVDIYNCVR
ELRSRRVNMV QTEEQYVFIH DAILEACLCG DTSVPASQVR SLYYDMNKLD PQTNSSQIKE
EFRTLNMVTP TLRVEDCSIA LLPRNHEKNR CMDILPPDRC LPFLITIDGE SSNYINAALM
DSYKQPSAFI VTQHPLPNTV KDFWRLALDY HCTSVVMLND VDPAQLCPQY WPENGVHRHG
PIQVEFVSAD LEEDIISRIF RIYNAARPQD GYRMVQQFQF LGWPMYRDTP VSKRSFLKLI
RQVDKWQEEY NGGEGRTVVH CLNGGGRSGT FCAISIVCEM LRHQRSVDVF HAVKTLRNNK
PNMVDLLDQY KFCYEVALEY LNSG
//
