ID G1TBR3_RABIT Unreviewed; 877 AA.
AC G1TBR3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 24-JAN-2024, entry version 74.
DE SubName: Full=Cation channel sperm associated 1 {ECO:0000313|Ensembl:ENSOCUP00000014177.4};
GN Name=CATSPER1 {ECO:0000313|Ensembl:ENSOCUP00000014177.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000014177.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000014177.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000014177.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000014177.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000014177.4};
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
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DR EMBL; AAGW02071500; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008271712.1; XM_008273490.2.
DR AlphaFoldDB; G1TBR3; -.
DR STRING; 9986.ENSOCUP00000014177; -.
DR PaxDb; 9986-ENSOCUP00000014177; -.
DR Ensembl; ENSOCUT00000016495.4; ENSOCUP00000014177.4; ENSOCUG00000016490.4.
DR GeneID; 100357804; -.
DR KEGG; ocu:100357804; -.
DR CTD; 117144; -.
DR eggNOG; KOG2302; Eukaryota.
DR GeneTree; ENSGT00940000162437; -.
DR HOGENOM; CLU_016037_0_0_1; -.
DR InParanoid; G1TBR3; -.
DR OrthoDB; 2914780at2759; -.
DR Proteomes; UP000001811; Chromosome 1.
DR Bgee; ENSOCUG00000016490; Expressed in testis and 4 other cell types or tissues.
DR GO; GO:0036128; C:CatSper complex; IEA:InterPro.
DR GO; GO:0005227; F:calcium activated cation channel activity; IEA:InterPro.
DR GO; GO:0030317; P:flagellated sperm motility; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 1.
DR InterPro; IPR028746; CatSper1.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR47193; CATION CHANNEL SPERM-ASSOCIATED PROTEIN 1; 1.
DR PANTHER; PTHR47193:SF1; CATION CHANNEL SPERM-ASSOCIATED PROTEIN 1; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 542..561
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 573..601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 656..674
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 680..702
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 714..734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 740..768
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 543..773
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 1..504
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 34..56
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 57..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 88..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 103..128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..212
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 225..348
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..402
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 409..428
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 432..450
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 461..484
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..499
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 877 AA; 99830 MW; B092EF3F4A586609 CRC64;
MSEKGQNEAD PDGGGVFTRP HSSPPQHRPG HGGALRHHES HHHRGASQHR GLARPHGGPR
HPREFQDNQD DRAFSHHAPR EAHHPTSLGL SPSRSIAPSH HSYSEDSSDD DQYHGNRVHH
HHAESSPHGG RQHLTVPPPY SGPHHHAEPD PHGGPHLLTV PPHHGGPHHH TEPGHHGGPH
HHTEPGHHGG PHHHAVSDHH GGPHHHAEPD PHGGPQHLTV PSHHGGPHRH AEPPHHGGPH
RHAEPDPHGG PHRHAEPSHH GGPHRYAEPD PHGGPHRHAE PSHHGGSHRH AEPDPHGGPH
RHAEPSHHGG PHRHAEPPHH GGPHRHVEDG HRGGLPHHGE PSYREEFHHK HARPHHHDSS
PHRRHPRYGD NVSCTSLDGS SHHGTPHHRE YHAPEHPHGE WPHHRSKHQR PRQPDDHPHS
DPRHRDYLWS PSDQSVPGTS QGSSSLSHPA TPHAHVHRWS SGHSTAPSHV AGSSKVCSQE
SSSKDSESYT EDNEQLRKRK TRRTPRSRKK LQLENCFQWW YEKLIVLFHG LQRMLWKLTH
CLAFETFIFL VVCLNTIMLV AQTFAEVEIR GEWHFLILDC IFLCIYMVEA LLKIIALGFS
YFHDFWNNLD FCIMMVAVLD FTLMQLNPLS YSFYHQSLFR ILKVFKSMRA LRAIRVLRRL
SFLTSLHEVT GTLARSLPSI TAIFVLMFTC LFLFSVVLRA LFRKSDPKRF QNIFSTLFTL
FTMLTLDDWS LIYMDNRAQG AWYIIPILMV YIIIQYFIFL NLVIAVLVDN FQMALLKGLE
KVRQERAARI QENLLDDSLT ELRQAEPKEI RSEGTMQKQL LEKKFGTLTE KQRQLLFQFL
QLVAGVEQQQ QKFRSQASVI DEIVDTAFEA GEEDFRK
//