ID G1TC31_RABIT Unreviewed; 837 AA.
AC G1TC31;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Prominin 1 {ECO:0000313|Ensembl:ENSOCUP00000014313.4};
GN Name=PROM1 {ECO:0000313|Ensembl:ENSOCUP00000014313.4};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000014313.4, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000014313.4, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000014313.4,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000014313.4}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000014313.4};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell projection, microvillus membrane
CC {ECO:0000256|ARBA:ARBA00004475}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004475}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the prominin family.
CC {ECO:0000256|ARBA:ARBA00006058}.
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DR EMBL; AAGW02010043; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02010044; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02010045; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02010046; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1TC31; -.
DR PaxDb; 9986-ENSOCUP00000014313; -.
DR Ensembl; ENSOCUT00000016648.4; ENSOCUP00000014313.4; ENSOCUG00000016642.4.
DR eggNOG; KOG4331; Eukaryota.
DR GeneTree; ENSGT00530000063586; -.
DR HOGENOM; CLU_008293_0_0_1; -.
DR TreeFam; TF324631; -.
DR Proteomes; UP000001811; Chromosome 2.
DR Bgee; ENSOCUG00000016642; Expressed in testis and 15 other cell types or tissues.
DR GO; GO:0031528; C:microvillus membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR008795; Prominin.
DR PANTHER; PTHR22730; PROMININ PROM PROTEIN; 1.
DR PANTHER; PTHR22730:SF3; PROMININ-1; 1.
DR Pfam; PF05478; Prominin; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..837
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023807928"
FT TRANSMEM 108..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 158..179
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 434..461
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 482..508
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 795..815
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 837 AA; 94304 MW; 8FA19B0B0B9FB4E2 CRC64;
MAHLLGFLLL LLGLCGDLVS GGQPSAPRPL EALNYTLPTA KYRIQQAYEV GPIGALFRMV
HVFLYVVQPH AFPEDTVRKI IQKKFEPSVD YEKPENIVLA LKVVYYEMGI IICSFLGLLF
ILLMPLVGCF VCICRCCNKC GGKMHQREKE DMVFRRKCLG ATLLVICILI SLGIIYGFVA
NHQVRTRVKR TRRLADSTFR DLRTFLDQTP KQIKYILAQY NTTKDLAFSD LNNINSKLGG
EICGQLKPVV IPVLDEIKAM ATAIRETKEA LESMKSSLDS LHSSSEQLNR SLTDVRTSVE
QSLQDPQCLV QPGVETCSSI QTSLSQLQGN SELGQLPSVD AELNKVNDVL STDLDGMVEQ
GYKSFNDIPE RVQQQSTAVV AEIKKVLDST GSEIDSVTQQ LPIKETLDNF IGYMNESEKY
LHDILPKVEE ADSYWWLVCL IICFLLTLII IFFNLGLLLG VCGYNRLATP TTRGCVSNTG
GIFLMVGAGL SFLFSWILML LVVVAFIVGA NMEKLICEPY ANRKLFRVLD TPYLLNEDWK
YYLSGMVLSK PDIKLTFEQV YSDCKDDKGI YTTLQLQNRF NITEQLDIGQ HTQKLVREFE
SMNINLDGIV LLDDSGKRNL QEFSECGIDK IDYASYLTQT GKSPTKVNLL SFAYDLEAKA
NHLPPGNLKN SMKEAAQNIT AIHEQQVIPM EQSLVTLHRS VKTLQRTSGS LQKGVNKTLY
SLDDAQNFIT RNISSIIIKE TKKFGRTIIS HFEYYLQWVE YAITEKLASC KPVATALDST
VQVIFCTYLT DPLNLFWFGI GKATLLLLPA LILGIKLAKY YRRMESEDVY DDEPLRY
//
