ID G1TCQ0_RABIT Unreviewed; 712 AA.
AC G1TCQ0;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 19-OCT-2011, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN Name=SLCO4C1 {ECO:0000313|Ensembl:ENSOCUP00000014569.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000014569.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000014569.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000014569.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000014569.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000014569.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
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DR EMBL; AAGW02043699; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02043700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02043701; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002714000.1; XM_002713954.3.
DR AlphaFoldDB; G1TCQ0; -.
DR STRING; 9986.ENSOCUP00000014569; -.
DR PaxDb; 9986-ENSOCUP00000014569; -.
DR Ensembl; ENSOCUT00000016955.4; ENSOCUP00000014569.2; ENSOCUG00000016948.4.
DR GeneID; 100357486; -.
DR KEGG; ocu:100357486; -.
DR CTD; 353189; -.
DR eggNOG; KOG3626; Eukaryota.
DR GeneTree; ENSGT01080000257410; -.
DR HOGENOM; CLU_008954_2_1_1; -.
DR InParanoid; G1TCQ0; -.
DR OMA; QFFSGEY; -.
DR OrthoDB; 2874223at2759; -.
DR TreeFam; TF317540; -.
DR Proteomes; UP000001811; Chromosome 11.
DR Bgee; ENSOCUG00000016948; Expressed in adult mammalian kidney and 6 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008514; F:organic anion transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR CDD; cd17463; MFS_SLCO4C_OATP4C; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF103; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 4C1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 96..118
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 162..183
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 217..241
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 253..281
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 301..323
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 375..397
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 409..436
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 448..466
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 572..596
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 608..631
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 660..683
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 95..680
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT DOMAIN 487..542
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 712 AA; 77173 MW; 41ADEA55790D3944 CRC64;
MKGAQGIENP AFVPCSPDTS RRLSPSPSQV QVSVASSDAQ GAESRPQEEP KSPEAPPASA
EPPGPPSRSE FEEGPCGWRN FHPRCLQRCN TPRGFLLHYC LLALTQGIVV NGLVNISIST
IEKRYEMKSS LTGLISSSYD ISFCVLSLFV SFIGERGHKP RWLAFASFMI GLGALVFSLP
QFFSGQYHLG SIFEDTCLTA RNSTSCTSST SSLSNYLYVF ILGQLLLGMG GTPLYTLGTA
FIDDSAPTHT SSLYIGIGYS MSILGPAIGY VLGGQLLTMY IDVAMGLSTD ITEDDPRWLG
AWWIGFLICW LFAWSLIIPF SCFPKHLPGT AKIQAEKISQ THQNKSSSSQ HTDENFGKSF
KDFPAALKNL MRNTVFMCLV LSTSSEALVT TGFATFLPKF IENQFGLTSS FAATLGGAVL
IPGAALGQIL GGVIVSKFKM TCKNTMRFAL ATSGVALVLS FVFIYAKCEN RPFAGVSESY
NGTGELGNLS APCNANCNCL RSYYYPLCGG DGVQYFSPCF AGCLNTVSKS KPKLYYNCSC
TEKKTETTLT AEGLSFEAKA GKCETQCTNL PIFLGVFFIT VVFTFMAGTP ITVSILRCVN
QRQRSLALGI QFMLLRLLGT IPGPIIFGVI IDSTCILWDI NECGIKGACW LYNNIKMAHM
LVAISVTCKI ITIFFNGLAV FLYKPPPSGT DVLFQNQNAV VVEHVSKAED EG
//
