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Database: UniProt
Entry: G1TG95_RABIT
LinkDB: G1TG95_RABIT
Original site: G1TG95_RABIT 
ID   G1TG95_RABIT            Unreviewed;      2177 AA.
AC   G1TG95;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   25-OCT-2017, entry version 42.
DE   RecName: Full=Voltage-dependent T-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=CACNA1G {ECO:0000313|Ensembl:ENSOCUP00000015945};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000015945, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000015945, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000015945}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000015945};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. This channel gives
CC       rise to T-type calcium currents. T-type calcium channels belong to
CC       the "low-voltage activated (LVA)" group and are strongly blocked
CC       by nickel and mibefradil. A particularity of this type of channels
CC       is an opening at quite negative potentials, and a voltage-
CC       dependent inactivation. T-type channels serve pacemaking functions
CC       in both central neurons and cardiac nodal cells and support
CC       calcium signaling in secretory cells and vascular smooth muscle.
CC       They may also be involved in the modulation of firing patterns of
CC       neurons which is important for information processing as well as
CC       in cell growth processes. {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000015945}.
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DR   EMBL; AAGW02039529; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02039530; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02039531; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 9986.ENSOCUP00000015945; -.
DR   Ensembl; ENSOCUT00000030629; ENSOCUP00000015945; ENSOCUG00000002733.
DR   eggNOG; KOG2302; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   InParanoid; G1TG95; -.
DR   OMA; FWRLICD; -.
DR   OrthoDB; EOG091G02L1; -.
DR   TreeFam; TF313555; -.
DR   Proteomes; UP000001811; Chromosome 19.
DR   Bgee; ENSOCUG00000002733; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:Ensembl.
DR   GO; GO:0008332; F:low voltage-gated calcium channel activity; IEA:Ensembl.
DR   GO; GO:0097110; F:scaffold protein binding; IEA:Ensembl.
DR   GO; GO:0086056; F:voltage-gated calcium channel activity involved in AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0086059; F:voltage-gated calcium channel activity involved SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0070509; P:calcium ion import; IEA:Ensembl.
DR   GO; GO:0086002; P:cardiac muscle cell action potential involved in contraction; IEA:Ensembl.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:Ensembl.
DR   GO; GO:0060371; P:regulation of atrial cardiac muscle cell membrane depolarization; IEA:Ensembl.
DR   GO; GO:0086091; P:regulation of heart rate by cardiac conduction; IEA:Ensembl.
DR   GO; GO:0010045; P:response to nickel cation; IEA:Ensembl.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR005445; VDCC_T_a1.
DR   InterPro; IPR030154; VDCC_T_a1G.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF137; PTHR10037:SF137; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01629; TVDCCALPHA1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     14     33       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     54     74       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    146    169       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    264    285       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    291    316       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    655    673       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    685    706       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    776    795       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    852    875       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1187   1205       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1225   1246       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1258   1277       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1322   1344       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1424   1447       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1522   1543       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1555   1578       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1656   1675       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1739   1761       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       12    327       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      654    880       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1185   1457       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1521   1771       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED     1456   1483       {ECO:0000256|SAM:Coils}.
FT   COILED     1760   1784       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2177 AA;  241564 MW;  8281871D2CA79988 CRC64;
     DSAPNSWCLR CHTWFERISM LVILLNCVTL GMFRPCEDIA CDSQRCRILQ AFDDFIFAFF
     AVEMVVKMVA LGIFGKKCYL GDTWNRLDFF IVIAGMLEYS LDLQNVSFSA VRTVRVLRPL
     RAINRVPSMR ILVTLLLDTL PMLGNVLLLC FFVFFIFGIV GVQLWAGLLR NRCFLPENFS
     LPLSVDLERY YQTENEDESP FICSQPRENG MRSCRSVPTC GLDYEAYNSS SNTTCVNWNQ
     YYTNCSAGEH NPFKGAINFD NIGYAWIAIF QVITLEGWVD IMYFVMDAHS FYNFIYFILL
     IIVGSFFMIN LCLVVIATQF SETKQRESQL MREQRVRFLS NASTLASFSE PGSCYEELLK
     YLVYILRKAA RRLAQVSRAV GVRAGLLSSP APLGSQEPQA SSSCSRSHRR LSVHHLLGNG
     TLRAPRASPE IQDRDANGSR RLMLPAPSTP TLSGGPAPGG AESVHSFYHA DCHLEPVRCQ
     APPPRSPSEA SGRTVGSGKV YPTVHTSPPP EMLKEKALVE VAPSSGPPTL TSLNIPPGPY
     SSMHKLLETQ STGTCQSSCK ISSPCLKADR GACGPDSCPY CARAGSGEVE LADREMPDSD
     SEAVYEFTQD VQQSDLRDPH GRRRRSQGCD AEPSPVLAFW RLICDTFRKI VDSKYFGRGI
     MIAILVNTLS MGIEYHEQPE ELTNALEISN IVFTSLFALE MLLKLLVYGP FGYIKNPYNI
     FDGVIVVISV WEIVGQQGGG LSVLRTFRLM RVLKLVRFLP ALQRQLVVLM KTMDNVATFC
     MLLMLFIFIF SILGMHLFGC KFASERDGDT LPDRKNFDSL LWAIVTVFQI LTQEDWNKVL
     YNGMASTSSW AALYFIALMT FGNYVLFNLL VAILVEGFQA EEISKREDTS GQLSCIQLPV
     NSQGGDATKS ESEPDFFSPS LDGDGDRKKH LALVSLGEHP ELRKSLLPPL IIHTAATPMS
     LPKSNSTGLG EALGPSSRRT SSSGSAEPGV AHEMKSPPSA RSSPHSPWSA ASSWTSRRSS
     RNSLGRAPSL KRRSPSGERR SLLSGEGRES QDEESSEEER ASPAGSDRRH RGSLEREAKS
     SFDLPDTLQV PGLHRTASGR SSASEHQDCN GKSASGRLAR ALRPDDPPLD GDDGDDEGNL
     SKGERIRAWV RARLPACCRE RDAWSAYIFP PQSRFRLLCH RIITHKMFDH VVLVIIFLNC
     ITIAMERPKI DPHSAERIFL TLSNYIFTAV FLAEMTVKVV ALGWCFGEQA YLRSSWNVLD
     GLLVLISVID ILVSMVSDSG TKILGMLRVL RLLRTLRPLR VISRAQGLKL VVETLMSSLK
     PIGNIVVICC AFFIIFGILG VQLFKGKFFV CQGEDTRNIT NKSDCAEASY RWVRHKYNFD
     NLGQALMSLF VLASKDGWVD IMYDGLDAVG VDQQPIMNHN PWMLLYFISF LLIVAFFVLN
     MFVGVVVENF HKCRQHQEEE EARRREEKRL RRLEKKRRNL MLDDVIASGS SASAASEAQC
     KPYYSDYSRF RLLVHHLCTS HYLDLFITGV IGLNVVTMAM EHYQQPQILD EALKICNYIF
     TVIFVLESVF KLVAFGFRRF FQDRWNQLDL AIVLLSIMGI TLEEIEVNAS LPINPTIIRI
     MRVLRIARVL KLLKMAVGMR ALLDTVMQAL PQVGNLGLLF MLLFFIFAAL GVELFGDLEC
     DETHPCEGLG RHATFRNFGM AFLTLFRVST GDNWNGIMKD TLRDCDQEST CYNTVISPIY
     FVSFVLTAQF VLVNVVIAVL MKHLEESNKE AKEEAELEAE LELELKTLSP QPRSPLGSPF
     LWPGAEGPDS PDSSKPGAPQ PAAHTRAASR FSLEHPTMEP HPEEVPAALG PDLLTVRKAG
     VSRTHSLPND SYMCRDGSTA EGSLGPRGWG LPKAQSGSVL SVHSQPADTS YNLQLPKDAP
     NLLQPHSAPT WGTIPKLPPP GRSPLAQRPL RRQASSLVAK RRASLLGHRA EAPITGSPQT
     PTPPRQXFWG RPSIRARQHF RSQSKISKHM ALSALCPGPE PSRSKGPPET RSSFELDTEL
     SWVSGDLLAL GSQEAPPSPR DLKKCYSVEA QSGRRRPVSW LDEQRRHSIA VSCLDGGSSL
     AGQPLGGPGS RPKKKLSPPS ISIDPPESIC LRRRAPSSDA KDPSASGPSD SMAASPSPKK
     DVLSLSGLSS DPADLDP
//
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