ID G1TGG3_RABIT Unreviewed; 655 AA.
AC G1TGG3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Zinc finger BED-type containing 1 {ECO:0000313|Ensembl:ENSOCUP00000016013.2};
GN Name=ZBED1 {ECO:0000313|Ensembl:ENSOCUP00000016013.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000016013.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000016013.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000016013.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000016013.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; G1TGG3; -.
DR SMR; G1TGG3; -.
DR STRING; 9986.ENSOCUP00000016013; -.
DR PaxDb; 9986-ENSOCUP00000016013; -.
DR Ensembl; ENSOCUT00000028949.2; ENSOCUP00000016013.2; ENSOCUG00000023740.2.
DR eggNOG; KOG1121; Eukaryota.
DR GeneTree; ENSGT00940000163186; -.
DR HOGENOM; CLU_009123_12_2_1; -.
DR InParanoid; G1TGG3; -.
DR TreeFam; TF322818; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000023740; Expressed in embryo and 17 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
DR GO; GO:0016605; C:PML body; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0061665; F:SUMO ligase activity; IEA:Ensembl.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR GO; GO:0044828; P:negative regulation by host of viral genome replication; IEA:Ensembl.
DR InterPro; IPR008906; HATC_C_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR003656; Znf_BED.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR PANTHER; PTHR46169; DNA REPLICATION-RELATED ELEMENT FACTOR, ISOFORM A; 1.
DR PANTHER; PTHR46169:SF2; E3 SUMO-PROTEIN LIGASE ZBED1; 1.
DR Pfam; PF05699; Dimer_Tnp_hAT; 1.
DR Pfam; PF02892; zf-BED; 1.
DR SMART; SM00614; ZnF_BED; 1.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 1.
DR SUPFAM; SSF140996; Hermes dimerisation domain; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS50808; ZF_BED; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00027}.
FT DOMAIN 20..78
FT /note="BED-type"
FT /evidence="ECO:0000259|PROSITE:PS50808"
FT REGION 523..546
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 655 AA; 73414 MW; E1161E1FBBBB6C6B CRC64;
MESKSLEGPQ ADLKLVAHPR AKSKVWKYFG FDTDADGCIL QWKRIYCRIC MAQIAYSGNT
SNLSYHLEKN HPEEFCEFVK SNTEQMREAF ATAFSRLKPE ASSLQSVPDT LATTTAPAKA
GHSYESKKQQ ELTAAILGLI CEGLYPASIV DEPTFRVLLR TADPKYELPS RKFFTSKAIP
QKYGEVREAV LKELADASWC GISTDTWRSH SQNRAYVTLA AHFLGVGSPS GLSMGSRCLK
TFEVPEDNMA ETITRVLYEA FIEWGLSTKV FGATTDAGRD MAKACSLLDI PVQMPCLGHA
FDVAIQQAFQ LPKLAGLLSR CRRLVEYFQH SPVAMCILYE KQRQQGVATP PCMLVSDRVC
WWGSTLAMLR RLQEQQLVVA AVLVEDSNNH HLMLESAEWT TVAGLVDLLQ PFQQVAETLA
TSRYPAISMV KPLLHMLLNS TLSAKDTDPK EISMAKEVIA KELSRTYQDS PEVDLFLNVA
TFLDPRYKRL PFLSAFKRQQ VENRVVDELK GLLDKAQDAH LGPTASEDKV YPVPEEPPAK
KLPLASTPPS STAIHDLLAE IFCPVDCGED QEEWHAQAME ELSNFKSQKL LGLHEDPLKW
WSDRLALFPG LPKVLQKYWC VAATRVFPER LFGSSANMER NLCILGYICL FLLLK
//
