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Database: UniProt
Entry: G1TIT8_RABIT
LinkDB: G1TIT8_RABIT
Original site: G1TIT8_RABIT 
ID   G1TIT8_RABIT            Unreviewed;      2640 AA.
AC   G1TIT8;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   25-APR-2018, entry version 45.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSOCUP00000016860};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSOCUP00000016860};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000016860, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000016860, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000016860}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000016860};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
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DR   EMBL; AAGW02026444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOCUT00000026779; ENSOCUP00000016860; ENSOCUG00000002425.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; G1TIT8; -.
DR   OMA; KRIRIHY; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000001811; Chromosome 16.
DR   Bgee; ENSOCUG00000002425; -.
DR   GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
DR   GO; GO:0033017; C:sarcoplasmic reticulum membrane; IEA:Ensembl.
DR   GO; GO:0005790; C:smooth endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR   GO; GO:0048763; F:calcium-induced calcium release activity; IEA:Ensembl.
DR   GO; GO:0005516; F:calmodulin binding; IEA:Ensembl.
DR   GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR   GO; GO:0034236; F:protein kinase A catalytic subunit binding; IEA:Ensembl.
DR   GO; GO:0034237; F:protein kinase A regulatory subunit binding; IEA:Ensembl.
DR   GO; GO:0043621; F:protein self-association; IEA:Ensembl.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:Ensembl.
DR   GO; GO:0043924; F:suramin binding; IEA:Ensembl.
DR   GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
DR   GO; GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IEA:Ensembl.
DR   GO; GO:0060070; P:canonical Wnt signaling pathway; IEA:Ensembl.
DR   GO; GO:0003300; P:cardiac muscle hypertrophy; IEA:Ensembl.
DR   GO; GO:0071313; P:cellular response to caffeine; IEA:Ensembl.
DR   GO; GO:0071872; P:cellular response to epinephrine stimulus; IEA:Ensembl.
DR   GO; GO:0005513; P:detection of calcium ion; IEA:Ensembl.
DR   GO; GO:0003143; P:embryonic heart tube morphogenesis; IEA:Ensembl.
DR   GO; GO:0072599; P:establishment of protein localization to endoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
DR   GO; GO:1901896; P:positive regulation of calcium-transporting ATPase activity; IEA:Ensembl.
DR   GO; GO:0010460; P:positive regulation of heart rate; IEA:Ensembl.
DR   GO; GO:0051284; P:positive regulation of sequestering of calcium ion; IEA:Ensembl.
DR   GO; GO:0098735; P:positive regulation of the force of heart contraction; IEA:Ensembl.
DR   GO; GO:0086029; P:Purkinje myocyte to ventricular cardiac muscle cell signaling; IEA:Ensembl.
DR   GO; GO:0098910; P:regulation of atrial cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0098904; P:regulation of AV node cell action potential; IEA:Ensembl.
DR   GO; GO:0010881; P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion; IEA:Ensembl.
DR   GO; GO:0098907; P:regulation of SA node cell action potential; IEA:Ensembl.
DR   GO; GO:0098911; P:regulation of ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   GO; GO:0014808; P:release of sequestered calcium ion into cytosol by sarcoplasmic reticulum; IEA:Ensembl.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   GO; GO:0014850; P:response to muscle activity; IEA:Ensembl.
DR   GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
DR   GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR   GO; GO:0097050; P:type B pancreatic cell apoptotic process; IEA:Ensembl.
DR   GO; GO:0086005; P:ventricular cardiac muscle cell action potential; IEA:Ensembl.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT   DOMAIN      216    426       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      642    839       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      974   1179       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED       89    109       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2640 AA;  298404 MW;  17C7148F245F7C72 CRC64;
     MGSIQRKAIM HHEGHMDDGL NLSRSQHEES RTARVIRSTV FLFNRFIRGL DALSKKAKAS
     SVDLPIESVS LSLQDLIGYF HPPDEHLEHE DKQNRLRALK NRQNLFQEEG MINLVLECID
     RLHVYSSAAH FADVAGREAG ESWKSILNSL YELLAALIRG NRKNCAQFSG SLDWLISRLE
     RLEASSGILE VLHCVLVESP EALNIIKEGH IKSIISLLDK HGRNHKVLDV LCSLCVCHGV
     AVRSNQHLIC DNLLPGRDLL LQTRLVNHVS SMRPNIFLGV SEGSAQYKKW YYELMVDHTE
     PFVTAEATHL RVGWASTEGY SPYPGGGEEW GGNGVGDDLF SYGFDGLHLW SGCIARTVSS
     PNQHLLRTDD VISCCLDLSA PSISFRINGQ PVQGMFENFN IDGLFFPVVS FSAGIKVRFL
     LGGRHGEFKF LPPPGYAPCY EAVLPKEKLK VEHSREYKQE RTYTRDLLGP TVSLTQAAFT
     PIPVDTSQIV LPPHLERIRE KLAENIHELW VMNKIELGWQ YGPVRDDNKR QHPCLVEFSK
     LPEQERNYNL QMSLETLKTL LALGCHVGIS DEHAEEKVKK MKLPKNYQLT SGYKPAPMDL
     SFIKLTPSQE AMVDKLAENA HNVWARDRIR QGWTYGIQQD VKNRRNPRLV PYTLLDDRTK
     KSNKDSLREA VRTLLGYGYN LEAPDQDHAA RAEVCSGTGE RFRIFRAEKT YAVKAGRWYF
     EFEAVTSGDM RVGWSRPGCQ PDQELGSDER AFAFDGFKAQ RWHQGNEHYG RSWQAGDVVG
     CMVDMNEHTM MFTLNGEILL DDSGSELAFK DFDVGDGFIP VCSLGVAQVG RMNFGKDVST
     LKYFTICGLQ EGYEPFAVNT NRDITMWLSK RLPQFLQVPS NHEHIEVTRI DGTIDSSPCL
     KVTQKSFGSQ NSNTDIMFYR LSMPIECAEV FSKTVPGGLP GAGLFGPKND LEDYDADSDF
     EVLMKTAHGH LVPDRVDKDK ETTKAEFNNH KDYAQEKPSR LKQRFLLRRT KPDYSTSHSA
     RLTEDVLADD RDDYDFLMQT STYYYSVRIF PGQEPANVWV GWITSDFHQY DTGFDLDRVR
     TVTVTLGDEK GKVHESIKRS NCYMVCAGES MSPGQGRNNN GLEIGCVVDA ASGLLTFIAN
     GKELSTYYQV EPSTKLFPAV FAQATSPNVF QFELGRIKNV MPLSAGLFKS EHKNPVPQCP
     PRLHVQFLSH VLWSRMPNQF LKVDVSRISE RQGWLVQCLD PLQFMSLHIP EENRSVDILE
     LTEQEELLKF HYHTLRLYSA VCALGNHRVA HALCSHVDEP QLLYAIENKY MPGLLRTGYY
     DLLIDIHLSS YATARLMMNN EFIVPMTEET KSITLFPDEN KKHGLPGIGL STSLRPRMQF
     SSPSFVSINN ECYQYSPEFP LDILKAKTIQ MLTEAVKEGS LHARDPVGGT TEFLFVPLIK
     LFYTLLIMGI FHNEDLRHIL QLIEPSVFKD AATPEEEGDT LEEEPSVEDT KLEGAGEEEA
     KVGKRPKEGL LQMKLPEPVK LQMCLLLQYL CDCQVRHRIE AIVAFSDDFV AKLQDNQRFR
     YNEVMQALNM SAALTARKTK EFRSPPQEQI NMLLNFKDDK SECPCPEEIR DQLLDFHEDL
     MTHCGIELDE DGSLDGNSDL TIRGRLLSLV EKVTYLKKKQ TEKPVESDSR KSSTLQQLIS
     ETMVRWAQES VIEDPELVRA MFVLLHRQYD GIGGLVRALP KTYTINGVSV EDTINLLASL
     GQIRSLLSVR MGKEEEKLMI RGLGDIMNNK VFYQHPNLMR ALGMHETVME VMVNVLGGGE
     SKEITFPKMV ANCCRFLCYF CRISRQNQKA MFDHLSYLLE NSSVGLASPA MRGSTPLDVA
     AASVMDNNEL ALALREPDLE KVVVRYLAGC GLQSCQMLVS KGYPDIGWNP VEGERYLDFL
     RFAVFCNGES VEENANVVVR LLIRRPECFG PALRGEGGNG LLAAMEEAIK IAEDPSRDGP
     SPTSGSSKTL DTEEEEDDTI HMGNAIMTFY AALIDLLGRC APEMHLIHAG KGEAIRIRSI
     LRSLIPLGDL VGVISIAFQM PTIAKDGNVV EPDMSAGFCP DHKAAMVLFL DRVYGIEVQD
     FLLHLLEVGF LPDLRAAASL DTAALSATDM ALALNRYLCT AVLPLLTRCA PLFAGTEHHA
     SLIDSLLHTV YRLSKGCSLT KAQRDSIEVC LLSICGQLRP SMMQHLLRRL VFDVPLLNEH
     AKMPLKLLTN HYERCWKYYC LPGGWGNFGA ASEEELHLSR KLFWGIFDAL SQKKYEQELF
     KLALPCLSAV AGALPPDYME SNYVSMMEKQ SSMDSEGNFN PQPVDTSNII IPEKLEYFIN
     KYAEHSHDKW SMDKLANGWI YGEIYSDSSK IQPLMKPYKL LSEKEKEIYR WPIKESLKTM
     LAWGWRIERT REGDSMALYN RTRRISQTSQ VSVDAAHGYS PRAIDMSNVT LSRDLHAMAE
     MMAENYHNIW AKKKKLELES KGGGNHPLLV PYDTLTAKEK AKDREKAQDI LKFLQINGYA
     VSRGFKDLEL DTPSIEKRFA YSFLQQLIRY VDEAHQYILE FDGGSRSKGE HFPYEQEIKF
     FAKVVLPLID QYFKNHRLYF LSAASRPLCS GGHASNKEKE MVTSLFCKLG VLVRHRISLF
//
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