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Database: UniProt
Entry: G1TIT8_RABIT
LinkDB: G1TIT8_RABIT
Original site: G1TIT8_RABIT 
ID   G1TIT8_RABIT            Unreviewed;      2640 AA.
AC   G1TIT8;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   25-OCT-2017, entry version 39.
DE   SubName: Full=Ryanodine receptor 2 {ECO:0000313|Ensembl:ENSOCUP00000016860};
GN   Name=RYR2 {ECO:0000313|Ensembl:ENSOCUP00000016860};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae;
OC   Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000016860, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000016860, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J.,
RA   Washietl S., Kheradpour P., Ernst J., Jordan G., Mauceli E.,
RA   Ward L.D., Lowe C.B., Holloway A.K., Clamp M., Gnerre S., Alfoldi J.,
RA   Beal K., Chang J., Clawson H., Cuff J., Di Palma F., Fitzgerald S.,
RA   Flicek P., Guttman M., Hubisz M.J., Jaffe D.B., Jungreis I.,
RA   Kent W.J., Kostka D., Lara M., Martins A.L., Massingham T., Moltke I.,
RA   Raney B.J., Rasmussen M.D., Robinson J., Stark A., Vilella A.J.,
RA   Wen J., Xie X., Zody M.C., Baldwin J., Bloom T., Chin C.W., Heiman D.,
RA   Nicol R., Nusbaum C., Young S., Wilkinson J., Worley K.C., Kovar C.L.,
RA   Muzny D.M., Gibbs R.A., Cree A., Dihn H.H., Fowler G., Jhangiani S.,
RA   Joshi V., Lee S., Lewis L.R., Nazareth L.V., Okwuonu G.,
RA   Santibanez J., Warren W.C., Mardis E.R., Weinstock G.M., Wilson R.K.,
RA   Delehaunty K., Dooling D., Fronik C., Fulton L., Fulton B., Graves T.,
RA   Minx P., Sodergren E., Birney E., Margulies E.H., Herrero J.,
RA   Green E.D., Haussler D., Siepel A., Goldman N., Pollard K.S.,
RA   Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29
RT   mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000016860}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000016860};
RG   Ensembl;
RL   Submitted (SEP-2011) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSOCUP00000016860}.
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DR   EMBL; AAGW02026444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026445; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026447; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026448; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026449; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026450; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026452; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02026453; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSOCUT00000026779; ENSOCUP00000016860; ENSOCUG00000002425.
DR   eggNOG; KOG2243; Eukaryota.
DR   eggNOG; ENOG410YCNW; LUCA.
DR   GeneTree; ENSGT00760000119152; -.
DR   InParanoid; G1TIT8; -.
DR   OMA; KRIRIHY; -.
DR   OrthoDB; EOG091G00T0; -.
DR   TreeFam; TF315244; -.
DR   Proteomes; UP000001811; Chromosome 16.
DR   Bgee; ENSOCUG00000002425; -.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016020; C:membrane; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF49899; SSF49899; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001811};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT   DOMAIN      216    426       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      642    839       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      974   1179       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   2640 AA;  298404 MW;  17C7148F245F7C72 CRC64;
     MGSIQRKAIM HHEGHMDDGL NLSRSQHEES RTARVIRSTV FLFNRFIRGL DALSKKAKAS
     SVDLPIESVS LSLQDLIGYF HPPDEHLEHE DKQNRLRALK NRQNLFQEEG MINLVLECID
     RLHVYSSAAH FADVAGREAG ESWKSILNSL YELLAALIRG NRKNCAQFSG SLDWLISRLE
     RLEASSGILE VLHCVLVESP EALNIIKEGH IKSIISLLDK HGRNHKVLDV LCSLCVCHGV
     AVRSNQHLIC DNLLPGRDLL LQTRLVNHVS SMRPNIFLGV SEGSAQYKKW YYELMVDHTE
     PFVTAEATHL RVGWASTEGY SPYPGGGEEW GGNGVGDDLF SYGFDGLHLW SGCIARTVSS
     PNQHLLRTDD VISCCLDLSA PSISFRINGQ PVQGMFENFN IDGLFFPVVS FSAGIKVRFL
     LGGRHGEFKF LPPPGYAPCY EAVLPKEKLK VEHSREYKQE RTYTRDLLGP TVSLTQAAFT
     PIPVDTSQIV LPPHLERIRE KLAENIHELW VMNKIELGWQ YGPVRDDNKR QHPCLVEFSK
     LPEQERNYNL QMSLETLKTL LALGCHVGIS DEHAEEKVKK MKLPKNYQLT SGYKPAPMDL
     SFIKLTPSQE AMVDKLAENA HNVWARDRIR QGWTYGIQQD VKNRRNPRLV PYTLLDDRTK
     KSNKDSLREA VRTLLGYGYN LEAPDQDHAA RAEVCSGTGE RFRIFRAEKT YAVKAGRWYF
     EFEAVTSGDM RVGWSRPGCQ PDQELGSDER AFAFDGFKAQ RWHQGNEHYG RSWQAGDVVG
     CMVDMNEHTM MFTLNGEILL DDSGSELAFK DFDVGDGFIP VCSLGVAQVG RMNFGKDVST
     LKYFTICGLQ EGYEPFAVNT NRDITMWLSK RLPQFLQVPS NHEHIEVTRI DGTIDSSPCL
     KVTQKSFGSQ NSNTDIMFYR LSMPIECAEV FSKTVPGGLP GAGLFGPKND LEDYDADSDF
     EVLMKTAHGH LVPDRVDKDK ETTKAEFNNH KDYAQEKPSR LKQRFLLRRT KPDYSTSHSA
     RLTEDVLADD RDDYDFLMQT STYYYSVRIF PGQEPANVWV GWITSDFHQY DTGFDLDRVR
     TVTVTLGDEK GKVHESIKRS NCYMVCAGES MSPGQGRNNN GLEIGCVVDA ASGLLTFIAN
     GKELSTYYQV EPSTKLFPAV FAQATSPNVF QFELGRIKNV MPLSAGLFKS EHKNPVPQCP
     PRLHVQFLSH VLWSRMPNQF LKVDVSRISE RQGWLVQCLD PLQFMSLHIP EENRSVDILE
     LTEQEELLKF HYHTLRLYSA VCALGNHRVA HALCSHVDEP QLLYAIENKY MPGLLRTGYY
     DLLIDIHLSS YATARLMMNN EFIVPMTEET KSITLFPDEN KKHGLPGIGL STSLRPRMQF
     SSPSFVSINN ECYQYSPEFP LDILKAKTIQ MLTEAVKEGS LHARDPVGGT TEFLFVPLIK
     LFYTLLIMGI FHNEDLRHIL QLIEPSVFKD AATPEEEGDT LEEEPSVEDT KLEGAGEEEA
     KVGKRPKEGL LQMKLPEPVK LQMCLLLQYL CDCQVRHRIE AIVAFSDDFV AKLQDNQRFR
     YNEVMQALNM SAALTARKTK EFRSPPQEQI NMLLNFKDDK SECPCPEEIR DQLLDFHEDL
     MTHCGIELDE DGSLDGNSDL TIRGRLLSLV EKVTYLKKKQ TEKPVESDSR KSSTLQQLIS
     ETMVRWAQES VIEDPELVRA MFVLLHRQYD GIGGLVRALP KTYTINGVSV EDTINLLASL
     GQIRSLLSVR MGKEEEKLMI RGLGDIMNNK VFYQHPNLMR ALGMHETVME VMVNVLGGGE
     SKEITFPKMV ANCCRFLCYF CRISRQNQKA MFDHLSYLLE NSSVGLASPA MRGSTPLDVA
     AASVMDNNEL ALALREPDLE KVVVRYLAGC GLQSCQMLVS KGYPDIGWNP VEGERYLDFL
     RFAVFCNGES VEENANVVVR LLIRRPECFG PALRGEGGNG LLAAMEEAIK IAEDPSRDGP
     SPTSGSSKTL DTEEEEDDTI HMGNAIMTFY AALIDLLGRC APEMHLIHAG KGEAIRIRSI
     LRSLIPLGDL VGVISIAFQM PTIAKDGNVV EPDMSAGFCP DHKAAMVLFL DRVYGIEVQD
     FLLHLLEVGF LPDLRAAASL DTAALSATDM ALALNRYLCT AVLPLLTRCA PLFAGTEHHA
     SLIDSLLHTV YRLSKGCSLT KAQRDSIEVC LLSICGQLRP SMMQHLLRRL VFDVPLLNEH
     AKMPLKLLTN HYERCWKYYC LPGGWGNFGA ASEEELHLSR KLFWGIFDAL SQKKYEQELF
     KLALPCLSAV AGALPPDYME SNYVSMMEKQ SSMDSEGNFN PQPVDTSNII IPEKLEYFIN
     KYAEHSHDKW SMDKLANGWI YGEIYSDSSK IQPLMKPYKL LSEKEKEIYR WPIKESLKTM
     LAWGWRIERT REGDSMALYN RTRRISQTSQ VSVDAAHGYS PRAIDMSNVT LSRDLHAMAE
     MMAENYHNIW AKKKKLELES KGGGNHPLLV PYDTLTAKEK AKDREKAQDI LKFLQINGYA
     VSRGFKDLEL DTPSIEKRFA YSFLQQLIRY VDEAHQYILE FDGGSRSKGE HFPYEQEIKF
     FAKVVLPLID QYFKNHRLYF LSAASRPLCS GGHASNKEKE MVTSLFCKLG VLVRHRISLF
//
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