ID G1TM19_RABIT Unreviewed; 734 AA.
AC G1TM19;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 60.
DE SubName: Full=Plakophilin 1 {ECO:0000313|Ensembl:ENSOCUP00000018025.2};
GN Name=PKP1 {ECO:0000313|Ensembl:ENSOCUP00000018025.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000018025.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000018025.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000018025.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000018025.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000018025.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the beta-catenin family.
CC {ECO:0000256|ARBA:ARBA00005462}.
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DR EMBL; AAGW02025229; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02025230; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02025231; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02025232; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02053981; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02053982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; G1TM19; -.
DR SMR; G1TM19; -.
DR STRING; 9986.ENSOCUP00000018025; -.
DR PaxDb; 9986-ENSOCUP00000026434; -.
DR Ensembl; ENSOCUT00000022371.2; ENSOCUP00000018025.2; ENSOCUG00000021242.3.
DR GeneTree; ENSGT00940000156735; -.
DR InParanoid; G1TM19; -.
DR TreeFam; TF321877; -.
DR Proteomes; UP000001811; Chromosome 16.
DR Bgee; ENSOCUG00000021242; Expressed in autopod skin and 9 other cell types or tissues.
DR ExpressionAtlas; G1TM19; baseline.
DR GO; GO:0001533; C:cornified envelope; IEA:Ensembl.
DR GO; GO:0030057; C:desmosome; IEA:Ensembl.
DR GO; GO:1990124; C:messenger ribonucleoprotein complex; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005521; F:lamin binding; IEA:Ensembl.
DR GO; GO:0098609; P:cell-cell adhesion; IEA:InterPro.
DR GO; GO:0045110; P:intermediate filament bundle assembly; IEA:Ensembl.
DR GO; GO:1902373; P:negative regulation of mRNA catabolic process; IEA:Ensembl.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR028435; Plakophilin/d_Catenin.
DR PANTHER; PTHR10372:SF3; PLAKOPHILIN-1; 1.
DR PANTHER; PTHR10372; PLAKOPHILLIN-RELATED; 1.
DR Pfam; PF00514; Arm; 2.
DR SMART; SM00185; ARM; 7.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 3.
PE 3: Inferred from homology;
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT REPEAT 295..337
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 337..380
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 582..610
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
SQ SEQUENCE 734 AA; 81046 MW; BF2C14966EFE9471 CRC64;
MSLRQPSANR VTGQALSISR VTRAQPGTLF LLRPQRPSPS LPTWPCPGSL HVLTAFHQPL
QLPLPQSSTL SHSNRGSMYD GLADNYNNYG TTSRSSYFSK FQAGNGSWGY PIYNGTLKRE
TDNRRFSSYS QMENWGRHYP RGSYNTTGAG SDICFMQKIK ASRSEPDLYC DPRGTLRKGT
LGSKGQKTSQ NRYSFYSTCS GQKTTKKCPV RPPSCTSKQD PVCVPTICNK DLSFGHSRAS
SKICSEDIEC SGLTIPKAVQ YLSSQDEKYQ AIGAYYIQHT CFQDESAKQQ VYQLGGICKL
VDLLRSPNQN VQQAAAGALR NLVFRSATNK LETRRQGGIR EAVSLLRRTG STEIQKQLTG
LLWNLSSTDE LKEELVADAL PVLADRVIIP FSGWCDGNSN VSRDVVDPEV FFNATGCLRN
LSSADAGRQT MRNYVGLIDS LMAYVQNCVA ASRCDDKSVE NCMCILHNLS YRLDAEVPTR
YRQLEYNARN AYTEKSSTGC FSNKSDKMMN NNYDFPLPEE ESNPKGSSWL YHSDAIRTYL
NLMGKSKKDA TLEACAGALQ NLTASKGLMS SGMSQLIGLK EKGLPQIARL LQSGNSDVVR
SGASLLSNMS RHPALHRAMG NQVFPEVTRL LTSHTGNTSN SEDILSSACY TVRNLMASQP
QMAKQYLNGN VLHNLVNLCR GSTSPKAAEA ARLLLSDMWS NKELQGVLRQ HGFDRNMLGT
LAGASSLRNF TSRF
//
