ID G1TPK8_RABIT Unreviewed; 701 AA.
AC G1TPK8;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 13-NOV-2013, sequence version 2.
DT 27-MAR-2024, entry version 77.
DE RecName: Full=Neurofilament medium polypeptide {ECO:0000256|ARBA:ARBA00015894};
DE AltName: Full=160 kDa neurofilament protein {ECO:0000256|ARBA:ARBA00030258};
DE AltName: Full=Neurofilament 3 {ECO:0000256|ARBA:ARBA00033124};
DE AltName: Full=Neurofilament triplet M protein {ECO:0000256|ARBA:ARBA00032778};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000018944.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000018944.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000018944.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000018944.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000018944.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the intermediate filament family.
CC {ECO:0000256|RuleBase:RU000685}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAGW02011107; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_002709357.3; XM_002709311.4.
DR AlphaFoldDB; G1TPK8; -.
DR SMR; G1TPK8; -.
DR PaxDb; 9986-ENSOCUP00000018944; -.
DR Ensembl; ENSOCUT00000030367.3; ENSOCUP00000018944.2; ENSOCUG00000021430.3.
DR GeneID; 100009343; -.
DR KEGG; ocu:100009343; -.
DR CTD; 4741; -.
DR GeneTree; ENSGT00940000161685; -.
DR HOGENOM; CLU_012560_7_3_1; -.
DR InParanoid; G1TPK8; -.
DR OMA; TTYQDTI; -.
DR OrthoDB; 4640531at2759; -.
DR Proteomes; UP000001811; Chromosome 2.
DR Bgee; ENSOCUG00000021430; Expressed in brain and 8 other cell types or tissues.
DR GO; GO:0005882; C:intermediate filament; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.5.500; Single helix bin; 1.
DR Gene3D; 1.20.5.1160; Vasodilator-stimulated phosphoprotein; 1.
DR InterPro; IPR018039; IF_conserved.
DR InterPro; IPR039008; IF_rod_dom.
DR InterPro; IPR002957; Keratin_I.
DR PANTHER; PTHR45652; GLIAL FIBRILLARY ACIDIC PROTEIN; 1.
DR PANTHER; PTHR45652:SF3; NEUROFILAMENT MEDIUM POLYPEPTIDE; 1.
DR Pfam; PF00038; Filament; 1.
DR PRINTS; PR01248; TYPE1KERATIN.
DR SMART; SM01391; Filament; 1.
DR SUPFAM; SSF64593; Intermediate filament protein, coiled coil region; 1.
DR PROSITE; PS00226; IF_ROD_1; 1.
DR PROSITE; PS51842; IF_ROD_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Intermediate filament {ECO:0000256|ARBA:ARBA00022754,
KW ECO:0000256|RuleBase:RU000685};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 1..250
FT /note="IF rod"
FT /evidence="ECO:0000259|PROSITE:PS51842"
FT REGION 323..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 6..82
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 134..221
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 342..362
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 363..385
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 386..402
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..419
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 420..530
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 538..589
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 595..615
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 624..638
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 701 AA; 79368 MW; 69CF29656FF8E004 CRC64;
MVNHEKAQVQ LDSDHLEEDI HRLKERFEEE ARLRDDTEAA IRALRKDIEE SSLVKVELDK
KVQSLQDEVA FLRSNHEEEV ADLLAQIQAS HITVERKDYL KTDISSALKE IRSQLECHSD
QNMHQAEEWF KCRYAKLTEA AEQNKEAIRS AKEEIAEYRR QLQSKSIELE SVRGTKESLE
RQLSDIEERH NHDLSSYQDT IQQLENELRG TKWEMARHLR EYQDLLNVKM ALDIEIAAYR
KLLEGEETRF STFSGSITGP LYTHRQPSVT ISSKIQKTKV EAPKLKVQHK FVEEIIEETK
VEDEKSEMED ALTAIAEELA VSVKEEEKEE EAEGKEEEQE AEEEVAAAKK SPVKATTPEI
KEEEGEKEEE GQEEEEEEED EGVKSDQAEE GGSEKEGSSE KDEGEQEEGE TEAEGEVEEA
EAKEEKKTEE KSEEVAAKEE PVTEAKVGKP EKAKSPVPKS PVEEVKPKAE ATAGKGEQKE
EEEKVEEEKK EAAKESPKEE KVEKKEEKPK DVPKKKAESP VKEEAAEEAA TITKPTKVSV
EKEAKEEEKP QQQEKEKEKE KAEEEGGSEE EGSDQGSKEA KKEDIAVNGE VEGKEEEEQE
TKEKGSGREE EKGVVTNGLD LSPADEKKGG DRSEEKVVVT KKVEKITTEG GDGATKYITK
SVTVTQKVEE HEETFEEKLV STKKVEKVTS HAIVKEVTQS D
//
