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Database: UniProt
Entry: G1TRG8_RABIT
LinkDB: G1TRG8_RABIT
Original site: G1TRG8_RABIT 
ID   G1TRG8_RABIT            Unreviewed;       355 AA.
AC   G1TRG8;
DT   19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT   19-OCT-2011, sequence version 1.
DT   24-JAN-2024, entry version 77.
DE   RecName: Full=Guanine nucleotide-binding protein G(i) subunit alpha-2 {ECO:0000256|ARBA:ARBA00039891};
DE   AltName: Full=Adenylate cyclase-inhibiting G alpha protein {ECO:0000256|ARBA:ARBA00042569};
GN   Name=GNAI2 {ECO:0000313|Ensembl:ENSOCUP00000019624.1};
OS   Oryctolagus cuniculus (Rabbit).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX   NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000019624.1, ECO:0000313|Proteomes:UP000001811};
RN   [1] {ECO:0000313|Ensembl:ENSOCUP00000019624.1, ECO:0000313|Proteomes:UP000001811}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000019624.1,
RC   ECO:0000313|Proteomes:UP000001811};
RX   PubMed=21993624; DOI=10.1038/nature10530;
RA   Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA   Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA   Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA   Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA   Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA   Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA   Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA   Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA   Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA   Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA   Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA   Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA   Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA   Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA   Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT   "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL   Nature 478:476-482(2011).
RN   [2] {ECO:0000313|Ensembl:ENSOCUP00000019624.1}
RP   IDENTIFICATION.
RC   STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000019624.1};
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved
CC       as modulators or transducers in various transmembrane signaling
CC       systems. The G(i) proteins are involved in hormonal regulation of
CC       adenylate cyclase: they inhibit the cyclase in response to beta-
CC       adrenergic stimuli. May play a role in cell division.
CC       {ECO:0000256|ARBA:ARBA00037181}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004236}.
CC       Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
CC       {ECO:0000256|ARBA:ARBA00004300}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004370}.
CC   -!- SIMILARITY: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
CC       {ECO:0000256|ARBA:ARBA00006628}.
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DR   EMBL; AAGW02044108; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02044109; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02044110; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAGW02044111; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_008258899.1; XM_008260677.2.
DR   AlphaFoldDB; G1TRG8; -.
DR   SMR; G1TRG8; -.
DR   STRING; 9986.ENSOCUP00000019624; -.
DR   PaxDb; 9986-ENSOCUP00000019624; -.
DR   Ensembl; ENSOCUT00000029837.3; ENSOCUP00000019624.1; ENSOCUG00000011681.4.
DR   GeneID; 100339066; -.
DR   KEGG; ocu:100339066; -.
DR   CTD; 2771; -.
DR   eggNOG; KOG0082; Eukaryota.
DR   GeneTree; ENSGT00940000155125; -.
DR   HOGENOM; CLU_014184_6_0_1; -.
DR   InParanoid; G1TRG8; -.
DR   OMA; GMGCTVS; -.
DR   OrthoDB; 2897309at2759; -.
DR   TreeFam; TF300673; -.
DR   Proteomes; UP000001811; Chromosome 9.
DR   Bgee; ENSOCUG00000011681; Expressed in upper lobe of left lung and 16 other cell types or tissues.
DR   GO; GO:0044297; C:cell body; IEA:Ensembl.
DR   GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0030425; C:dendrite; IEA:Ensembl.
DR   GO; GO:0030496; C:midbody; IEA:Ensembl.
DR   GO; GO:0098992; C:neuronal dense core vesicle; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0031683; F:G-protein beta/gamma-subunit complex binding; IEA:InterPro.
DR   GO; GO:0005525; F:GTP binding; IMP:BHF-UCL.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007193; P:adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0051301; P:cell division; IEA:Ensembl.
DR   GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR   GO; GO:0007213; P:G protein-coupled acetylcholine receptor signaling pathway; IEA:Ensembl.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IMP:BHF-UCL.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR   GO; GO:0043434; P:response to peptide hormone; IMP:BHF-UCL.
DR   CDD; cd00066; G-alpha; 1.
DR   Gene3D; 1.10.400.10; GI Alpha 1, domain 2-like; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR001408; Gprotein_alpha_I.
DR   InterPro; IPR001019; Gprotein_alpha_su.
DR   InterPro; IPR011025; GproteinA_insert.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10218; GTP-BINDING PROTEIN ALPHA SUBUNIT; 1.
DR   PANTHER; PTHR10218:SF73; GUANINE NUCLEOTIDE-BINDING PROTEIN G(I) SUBUNIT ALPHA-2; 1.
DR   Pfam; PF00503; G-alpha; 1.
DR   PRINTS; PR00318; GPROTEINA.
DR   PRINTS; PR00441; GPROTEINAI.
DR   SMART; SM00275; G_alpha; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF47895; Transducin (alpha subunit), insertion domain; 1.
DR   PROSITE; PS51882; G_ALPHA; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00022707};
KW   Myristate {ECO:0000256|ARBA:ARBA00022707};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW   Transducer {ECO:0000256|ARBA:ARBA00023224}.
SQ   SEQUENCE   355 AA;  40481 MW;  D9AB739CA4B4DA1F CRC64;
     MGCTVSAEDK AAAERSKMID KNLREDGEKA AREVKLLLLG AGESGKSTIV KQMKIIHEDG
     YSEEECRQYR AVVYSNTIQS IMAIVKAMGN LQIDFADTSR NDDARQLFAL SAAAEEQGVL
     PEDLSGVIRR LWADQGVQAC FGRSREYQLN DSAAYYLNDL ERIAQSDYIP TQQDVLRTRV
     KTTGIVETHF TFKDLHFKMF DVGGQRSERK KWIHCFEGVT AIIFCVALSA YDLVLAEDEE
     MNRMHESMKL FDSICNNKWF TDTSIILFLN KKDLFEEKIT HSHLTICFPE YTGANKYDEA
     ASYIQSKFED LNKRKDTKEI YTHFTCATDT KNVQFVFDAV TDVIIKNNLK DCGLF
//
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