ID G1TTD4_RABIT Unreviewed; 853 AA.
AC G1TTD4;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=SID1 transmembrane family member 2 {ECO:0000313|Ensembl:ENSOCUP00000020304.3};
GN Name=SIDT2 {ECO:0000313|Ensembl:ENSOCUP00000020304.3};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000020304.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000020304.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000020304.3,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000020304.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000020304.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SID1 family.
CC {ECO:0000256|ARBA:ARBA00006618}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AAGW02009455; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008259095.1; XM_008260873.2.
DR AlphaFoldDB; G1TTD4; -.
DR STRING; 9986.ENSOCUP00000020304; -.
DR PaxDb; 9986-ENSOCUP00000020304; -.
DR Ensembl; ENSOCUT00000023963.3; ENSOCUP00000020304.3; ENSOCUG00000011955.4.
DR GeneID; 100346592; -.
DR CTD; 51092; -.
DR eggNOG; KOG1388; Eukaryota.
DR GeneTree; ENSGT00390000010091; -.
DR HOGENOM; CLU_357018_0_0_1; -.
DR InParanoid; G1TTD4; -.
DR OrthoDB; 3027694at2759; -.
DR Proteomes; UP000001811; Chromosome 1.
DR Bgee; ENSOCUG00000011955; Expressed in testis and 17 other cell types or tissues.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0035650; F:AP-1 adaptor complex binding; IEA:Ensembl.
DR GO; GO:0035612; F:AP-2 adaptor complex binding; IEA:Ensembl.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0051032; F:nucleic acid transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl.
DR GO; GO:0042593; P:glucose homeostasis; IEA:Ensembl.
DR GO; GO:0061178; P:regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
DR GO; GO:0009749; P:response to glucose; IEA:Ensembl.
DR GO; GO:0006401; P:RNA catabolic process; IEA:Ensembl.
DR GO; GO:0050658; P:RNA transport; IEA:Ensembl.
DR GO; GO:0003323; P:type B pancreatic cell development; IEA:Ensembl.
DR GO; GO:0044342; P:type B pancreatic cell proliferation; IEA:Ensembl.
DR InterPro; IPR025958; SID1_TM_fam.
DR PANTHER; PTHR12185:SF16; SID1 TRANSMEMBRANE FAMILY MEMBER 2; 1.
DR PANTHER; PTHR12185; SID1 TRANSMEMBRANE FAMILY MEMEBER; 1.
DR Pfam; PF13965; SID-1_RNA_chan; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..853
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023817403"
FT TRANSMEM 292..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 470..490
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 524..542
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 570..591
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 628..647
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 653..675
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 735..756
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 768..788
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 819..838
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 853 AA; 96960 MW; CE10E1933D76FA31 CRC64;
MFALGLAFLA LLVASVESHL GALGPKNVSQ KDAEFEHTYV DEVNSELVNI YTFNHTVTRN
RTEGVRVSVN VLNKQKDAPL LFVVRQKEAV VSFQVPLILR GLYQRKYLYQ KVERTLCQPP
TKNESEVQFF YVDVSTLSPV NTTYQLRVIR MDNFVLRTGE QFSFNTTAAQ PQYFKYEFPE
GVDSVIVKVT SNKAFPCSVI SIQDVLCPVY DLDNNVAFIG MYQTMTKKAA ITVQRKDFPS
NSFYVVVVVK TEDQACGGSL PFYPFVEDEP VDQGHRQKTL SVLVSQAVTS EAYVGGMLFC
LGIFLSFYLL TVLLACWENW RQRKKTLLVT VDRACPESGH PRVLADSFPG GSPYEGYNYG
SFESGSGSTD GLVDSSGTGD VSYGYQGLDQ FKRRLPSGQM RQLCIAMDHP FDPGATRPRL
DSMSSVEEDD YDTLTDIDSD KNVIRTKQYL YVADLARKDK RVLRKKYQIY FWNIATIAVF
YALPVVQLVI TYQTVVNVTG NQDICYYNFL CAHPLGNLSA FNNILSNLGY ILLGLLFLLI
ILQREINHNR ALLRNDLYAL ECGIPKHFGL FYAMGTALMM EGLLSACYHV CPNYTNFQFD
TSFMYMIAGL CMLKLYQKRH PDINASAYSA YACLAIVIFF SVLGVVFGKG NTAFWIVFSI
IHITATLLLS TQLYYMGRWK LDSGILRRVL HVLYTDCIRQ CSWPLYVDRM VLLVMGNIIN
WSLAAYGLIM RPNDFASYLL AIGICNLLLY FAFYIIMKLR SGERIKLIPL LCIVCTSVVW
GFALFFFFQG LSTWQKTPAE SREHNRDCIL LDFFDDHDIW HFLSSIAMFG SFLVLLTLDD
DLDTVQRDKI YVF
//