ID G1TUG6_RABIT Unreviewed; 4226 AA.
AC G1TUG6;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=PKHD1 like 1 {ECO:0000313|Ensembl:ENSOCUP00000020692.2};
GN Name=PKHD1L1 {ECO:0000313|Ensembl:ENSOCUP00000020692.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000020692.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000020692.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000020692.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000020692.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000020692.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AAGW02012834; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02012835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02012836; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02012837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02012838; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02012839; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02012840; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 9986.ENSOCUP00000020692; -.
DR PaxDb; 9986-ENSOCUP00000020692; -.
DR Ensembl; ENSOCUT00000026063.3; ENSOCUP00000020692.2; ENSOCUG00000004688.4.
DR eggNOG; KOG3610; Eukaryota.
DR GeneTree; ENSGT00940000157594; -.
DR HOGENOM; CLU_000057_1_0_1; -.
DR InParanoid; G1TUG6; -.
DR TreeFam; TF329582; -.
DR Proteomes; UP000001811; Chromosome 3.
DR Bgee; ENSOCUG00000004688; Expressed in blood and 8 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0120234; C:stereocilium coat; IEA:Ensembl.
DR GO; GO:0032426; C:stereocilium tip; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR CDD; cd00603; IPT_PCSR; 12.
DR Gene3D; 2.60.40.420; Cupredoxins - blue copper proteins; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 14.
DR Gene3D; 2.160.20.10; Single-stranded right-handed beta-helix, Pectin lyase-like; 1.
DR InterPro; IPR008972; Cupredoxin.
DR InterPro; IPR019316; G8_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR037524; PA14/GLEYA.
DR InterPro; IPR011658; PA14_dom.
DR InterPro; IPR006626; PbH1.
DR InterPro; IPR012334; Pectin_lyas_fold.
DR InterPro; IPR011050; Pectin_lyase_fold/virulence.
DR PANTHER; PTHR46769:SF2; FIBROCYSTIN-L; 1.
DR PANTHER; PTHR46769; POLYCYSTIC KIDNEY AND HEPATIC DISEASE 1 (AUTOSOMAL RECESSIVE)-LIKE 1; 1.
DR Pfam; PF10162; G8; 2.
DR Pfam; PF07691; PA14; 1.
DR Pfam; PF01833; TIG; 14.
DR SMART; SM01225; G8; 2.
DR SMART; SM00429; IPT; 12.
DR SMART; SM00710; PbH1; 12.
DR SUPFAM; SSF56988; Anthrax protective antigen; 1.
DR SUPFAM; SSF49503; Cupredoxins; 1.
DR SUPFAM; SSF81296; E set domains; 14.
DR SUPFAM; SSF51126; Pectin lyase-like; 2.
DR PROSITE; PS51484; G8; 2.
DR PROSITE; PS51820; PA14; 1.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 311..466
FT /note="PA14"
FT /evidence="ECO:0000259|PROSITE:PS51820"
FT DOMAIN 2159..2279
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
FT DOMAIN 3011..3149
FT /note="G8"
FT /evidence="ECO:0000259|PROSITE:PS51484"
FT REGION 4146..4173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4226 AA; 464833 MW; 630E76D7E757C907 CRC64;
MMILPPLYYL SGGSKIIPKV TEVIPKYGSI NGATRLTIRG EGFSQENQFN YGVDNAELGN
SVQLVSSFQS ISCDVEKDAS HSTHITCYTR AMPEGSYTVR VSVDGIPIAE NNTCKGHISS
WACTFNAKSF RTPTIRSITP LSGPPGTLIT IQGRIFTDVY GSNTALSSNG KNVRILRVYI
GGMPCELLIP QSDNLYGLTL DHPNGDMGSM ICKTTGTYIG EYWSSLFIEI LLFFLNRSFP
EQMAYFVSSL NKISMFQTYA EITSVSPSKG SIQGDTMLTI SGRFFDQTDF PVKVLVGGIF
HEHYLLCHLP ASGRGLKLEV WNNSRPVHLE EILGYNEKTP GYLGAHWVDS ASHVWPMEQD
TFVARFSGFL VPPDSDFYRF YIKGDDRYAI YFSQTGLPED KVRIAYHSAN ANSYFSSPTQ
RSDDIYLQKG REYYIEILLQ EYRLSAFVDV GLYQYKNVYT EQQTGDAINE EQVIKSQSTI
IQEIQVVTLE HWETASAANE VQQIVITSPC VEANSCSQYQ YRLIYNMEKT ALIPADATDF
ILQSALNDLW SIKPDKVQVM RTQNSQSFIY MITFISTRGD FELLDYEVLE GNNVTLYITE
QIKGKPSMET FTLNWDGIAS KPLTPWPSAD DFQVAVEEMV SAKCPPQIAN FEEGFAVKYF
RDYETDFNLE QINRGQKTAE TDAYCGRYSL KNPAVLFDSA DVKPNRIPYG DLSLFPYNQL
CFAYKGFLAN FIGLKFQFQD NGRITRSTDT QFPYKFAYGN TWTYTCIDLL DLIQAKYTGT
NFALQRIHLQ KASESHSFFV DIVYIGQTAT ISTSDEMPKR RLPALANKGI FFKHFQVNQI
KVNGSTMTSQ YSVTMTSYNC SYDIPLMAVS FGQIISNETE NESVYRGNNW PGESKIRIQR
IQEASPPISG SFDIQAYGQI LKGLPAAVSA ADLQFALQHL EEMGRVSVTR EGTCAGYSWN
IKWKSACGKQ NLLQINDSNI IGEKANMTVT KIKDGGLFRQ RILGDLLRTP NQQPQVEVYV
NGIPAKCSGD CGFTWDPIAT PLVLASSPSQ GSYEEGTILT IAGSGFSPSS AVSVSVGPVA
CSLLSVDENE IKCKILNGSA GQMPIAVSVA DVGLAHNVGG EAFHFIYQSQ VSHIWPDSGS
LAGGTLLTLS GSGFHENSTV LVGNGTCDVI EGDVNRIICR TPKRIEGIVD ISVITNGYQT
LEKDAFSYNC LQTPVITDFS PKVRTIRGEV NLTIKGYNFG NELTQKVAVY VGGKPCLVLH
WNFTDIRCLL PPLSPGKHDI QVEVRNWGFA STRYDKLNAS IQYILEVTNM FPQKGSVYGG
TEITVLGFGF SMIPAENTVL LGPFPCNVTS SSDNVIKCIL HSTGNVFSIT NSGEDSVHGS
GYAWSPSVLN ISVGDTVTWH WQAHPFLRGV GYRVFSVSSP GSVIYDGKGF TNGRQKSTSG
SFSYQFTSPG VHYYSSGYVD EAHSIFLQGV INVLPAETRH VPLHLFVGHT EATYAPGGPE
NLHWGSSVTG CLATEPLCGL NNSRVKNSNR LLFELSSCFS PSISNITPST GTVNELITIT
GHGFSNLTCA NKVTIGRHPC VVEKSSDNSI VCRIDPQNSM DVGIREIITL TVYNLGTAIN
TLPNEFDRHF VLMPNIDMVV PKAGSTTGKT RVTIKGSGFG ESSAGVEVLM GHFPCKILAV
NYTTIECETS PAPQQLVRVD LLVHGVPAQC QGKCSFSYLE SVTPSITGIF PNSIKGSAEV
LIEGGGFGTL LGEIAVFIGN QQFRAIEVNE NNITVLVTPL PAGLHPLSVV VGTKGLAVGN
LTLSSPAVAS VSPTSGSVGG GTTLTITGNG FYPGNTTVIV GRDPCRIISV NSSHVYCHTP
AGTAGTVGVK ILVNTVTYPT WSFTYALEDT PFLRGITPSR GPSGTEIEIT GSNFGTDILE
LSVLINSIQC NVTMVNDSVL RCIVGDHAGG TFPVMMHHET KGSALSTVVF EYPLDIQDIH
PHQGSFGGGQ TLMMTGTGFN PQNSIVLVCG SECAVDRLSS NYTTLLCKIP PNNGSGPEQA
CEVSVVNGKD SSQSRTLFTY TLSLTPLIDE IAPRRGSTAG GTRLTVTGSG FSENMQDVHI
TIGEALCDVE YSNKTHIICI TNAHRPSGWA PIRVNIRNMG LARLDNADFL YVDVWSSNYS
WGGETPPEEG SFVVITKGQT ILLDQSTPIL KMVLIQGGTL MFDEADIELQ AENILITDGG
TLQIGTEASP FQHKAVITLH GHLRSPELPV YGAKTLAVRE GILDLHGLPI PVIWTLLART
AKAGEQTLIL QEAVTWKAGD NIVIASTGHR HSQQENEKRT IAAVSSDGIT ITLTNPLNYT
HLGVAVTLPD GTLFEARAEV GILTRNILIR GSDNIEWNDK IPACPDGFDT GEFATQTCLQ
GKFGEEIGSD QFGGCIMFHA PVPSTNMVTG RIEYVEVFHA GQAFRLGRYP IHWHLLGDLH
FKSYVRGCAI HQTYNRAITI HNTHHLLVER NVIYDVKGGA FFIEDGIEHG NILQYNLAVF
VQQSTSLLND DVTPAAFWVT NPNNTIRHNA AAGGTHFGFW YRMNNHPDGP SYDQNICQKR
VPLGEFFNNT VHSQGWFGIW IFEEYFPMQT GSCTSIVPEP AIFNSLTTWN CQKGAEWVNG
GALQFHNFVM VNNYEAGIET KRILAPYVGG WGEAHGAVIK NAKIVGHLDE LGMGSTFCTT
KGLVLPFSEG LTVSSVHFMN FDRPNCVALG VTSITGVCNE RCGGWSAKFV DVQYFHTPNK
AGFRWEHEVV LMDLDGSLTG HKGHTVIPHS PLLDPSHCTQ EAEWSIGFPG SVCDTSVSFH
RLAFNKAAPS SLLEKDVVLS DSFGTSIVPF QKKRLTHMSG WMALIPNANH INWYFKDVDH
ITNISYTSTF YGFKEEDYVI ISHNFTQNPD MFNVIDMRNG SSNPLSWNTS KNGDWHLEAN
TSTLYYLVSG RSDLHQSQPI SGTLDPDVKD VIINFQAYCC ILQDCFPVHP PSRKSVPRRR
PAMYNLWSND SFWQSSQENN YTVPGPGANV VIPEGTWIVA DTDMPPMERL AIWGVLELED
IYYAGGTKSS HRKVVLNATY ISVQGGRLIG GWEDNPFKGE LQIVLRGNHS SPEWALPNGP
NQGAKVLGVF GELDLHGIPR SIYKTKLSET AEAGSKVLSL MDAVDWQEGE EIVITTTSYD
FHQTETRRII KILHDHKVLI LNDSLSYTHL AERYHVPGTG QSYTLAADVG ILSRNIKIVG
EDYPGWSKDS FGAHVLVGSF TENMMTFTGN ARISNVEFYH SGQEGFRDST DPRYAVTFLN
LGQLQEHGLS YVRGCAFHHG FSPAIGVFGT DGLDIDDNII HFTVGEGIRI WGDANRVRGN
LVVLSVWPGT YQNRKDLSST LWHAAIEINR GTNTVLQNNV VAGFGRAGYR IDGEPCSGQD
NPMEKWFNNE AHGGLYGIYM NQDGQPRCSL IQGFTIWACW DYGIYFQTTE SVHIYNVTLV
DNGMAIFPMI YTPAAISHKI SSKKVQIQNS LIVGSSPEFN CSDVLTNDDP NIELTASHRS
SRPLSGGRSG ICWPTFASAH NMAPRKPHAG IMSYNAISGR LDISGSTFVG FKNVCSGETN
VIFITNPLNE DLQHPIYVKN IQLVDTIEQS KIFIHRPDIS KVNPSDCIDM VCDAKRKSFL
RDMDGSFLGN SGSVIPQAEY EWNGNRQLGI GDYRIPKVML TFLNGSRIPV TEKAPYKGII
RDSTCKFIPE WQSYQCFGME YAMMVIESLD SDTETRRLSP VAIVSNGYVD LINGPQDHGW
CAGYTCQRRL SLFHSIVALN KSYEVYFTGT SPQNLRLMLL NVDHNEAVLV GIFFSTLQRL
DVYVSNSLVC PKNTIWNTQQ KYCEPHGRLH TEQFLPNLDS TVLGENYFDR IYQMLYLLVK
GTTPVEIHTT KVIFVSFQLP FLTDDDFYSS HNLVRNLALF LKIPSNKIRI SKIIRGENLR
RKRSMGLTIE LEIGDPPTQF LNNDTTGQMR LSELQEIASS LGQAVILGKT SSIFGFNISS
MSITSPIPSP SDSGWSKVTA QPVERSVFPV HHVAFVSSLS VITQPVAAQP GQPFSQQPSV
KAVDSDGACV SVGITSLTLK AILKDSNNNQ EVKLFDAFFF LGKNYKIEFI LDNVVRVESG
TFSLPAQTAS SGGSSSSGSS SSSSSTNNSK ASTVGPSAQI MTVVICCLTG RFLLLEIFMA
SIFILNRSIC KYDSFLFDIN LHILRY
//
