ID G1TZ77_RABIT Unreviewed; 1848 AA.
AC G1TZ77;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 2.
DT 27-MAR-2024, entry version 80.
DE SubName: Full=Myosin VB {ECO:0000313|Ensembl:ENSOCUP00000022397.2};
GN Name=MYO5B {ECO:0000313|Ensembl:ENSOCUP00000022397.2};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000022397.2, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000022397.2, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke inbred {ECO:0000313|Ensembl:ENSOCUP00000022397.2,
RC ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000022397.2}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000022397.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
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DR EMBL; AAGW02032389; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02032390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02032391; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02032392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02032393; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02032394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02032395; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAGW02032396; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR SMR; G1TZ77; -.
DR STRING; 9986.ENSOCUP00000022397; -.
DR PaxDb; 9986-ENSOCUP00000022397; -.
DR Ensembl; ENSOCUT00000031171.2; ENSOCUP00000022397.2; ENSOCUG00000009547.4.
DR eggNOG; KOG0160; Eukaryota.
DR GeneTree; ENSGT00940000155402; -.
DR HOGENOM; CLU_000192_9_3_1; -.
DR InParanoid; G1TZ77; -.
DR TreeFam; TF328771; -.
DR Proteomes; UP000001811; Chromosome 9.
DR Bgee; ENSOCUG00000009547; Expressed in liver and 15 other cell types or tissues.
DR GO; GO:0045179; C:apical cortex; IEA:Ensembl.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0016197; P:endosomal transport; IEA:Ensembl.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd15477; Myo5b_CBD; 1.
DR CDD; cd01380; MYSc_Myo5; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.190; -; 3.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR InterPro; IPR002710; Dilute_dom.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR037990; Myo5b_CBD.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR036103; MYSc_Myo5.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR13140; MYOSIN; 1.
DR PANTHER; PTHR13140:SF356; UNCONVENTIONAL MYOSIN-VB; 1.
DR Pfam; PF01843; DIL; 1.
DR Pfam; PF00612; IQ; 6.
DR Pfam; PF00063; Myosin_head; 1.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM01132; DIL; 1.
DR SMART; SM00015; IQ; 6.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51126; DILUTE; 1.
DR PROSITE; PS50096; IQ; 6.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 35..87
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 96..761
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT DOMAIN 1526..1803
FT /note="Dilute"
FT /evidence="ECO:0000259|PROSITE:PS51126"
FT REGION 640..662
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 1090..1122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1163..1191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 896..947
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1202..1264
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1333..1440
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1096..1122
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 190..197
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1848 AA; 213189 MW; D6AFC96A01D267C3 CRC64;
MCARGFKSWG RPCVGGDAFH SWKLCFVSES LVFIFQYTRV WIPDPEEVWR SAELTKDYKE
GDRCLQLRLE DETVREYPIN VQSNQLPFLR NPDILVGEND LTALSYLHEP AVLHNLKVRF
LESNHIYTYC GIVLVAINPY EQLPIYGQDV IYAYSGQNMG DMDPHIFAVA EEAYKQMARD
EKNQSIIVSG ESGAGKTVSA KYAMRYFATV GGSASDTNIE EKVLASSPIM EAIGNAKTTR
NDNSSRFGKY IQIGFDKRYH IIGANMRTYL LEKSRVVFQA DDERNYHIFY QLCAAASLPE
FKELALTCAE DFFYTSQGGD TCIEGVDDAE DFEKTRQAFT LLGVRESHQI SIFKIIASIL
HLGSVEIQAE RDGESCSISP QDEHLGNFCR LLGVEHSQME HWLCHRKLVT TSETYVKTMS
LQQVVNARNA LAKHIYAQLF SWIVEHINKA LHTSLKQHSF IGVLDIYGFE TFEVNSFEQF
CINYANEKLQ QQFNSHVFKL EQEEYMKEQI PWTLIDFYDN QPCIDLIEAK LGILDLLDEE
CKVPKGTDQN WAQKLYDRHS GSQHFQKPRM SNTAFIVVHF ADKFPLVSDL FHDDKDPAPA
TTAVGKGSSS KINIRSARPP LKASNKEHKK TVGHQFRTSL HLLMETLNAT TPHYVRCIKP
NDEKLPFHFD PKRAVQQLRA CGVLETIRIS AAGYPSRWAY HDFFNRYRVL VAKRELANTD
KKAVCKAVLQ DLLKDPDKFQ FGRTKIFFRA GQVAYLEKLR ADKFRAATIM IQKTVRGWLQ
KVKYRRLKGA TLTLQRYCRG YLARRLAEHL RRTRAAVVLQ KQYRMRRARL AYQRVRRAAI
VIQAFARAMF VRRIYRQVLM EHKATVIQKH VRGWRARRRF LQLRAAAIVM QCAFRRLKAK
RELKALKIEA RSAEHLKRLN VGMENKVVQL QRKIDDQNKE FKTLSEQLSA VTSTHAMEVE
KLKRELARYQ QSQDGDASLQ LQEEVQSLRT ELQRAHSERR VLEDAHSREK DQLRKRVADL
EQENALLKDE KEQLNNQILG QSRDEAAQSS MKENLMKKEL EEERARYQNL VKEFSRLEQR
YDNLRDEVAV IKQTPGHRRN PSNQSSLESD SNYPSISTSE IGDTEDALQQ VEEVGLEKAA
MDMTVFLKLQ KRVRELEQER KKLQGQLEKR EQQDSRKNQA EQPKNDLDLD QDADLAYNSL
KRQELESENK RLKNDLNELR KAVADHATQD DATHSSPDGY SLLLNQLRLA NEELEVRKEE
VLILRTQIVS ADQRRLAGKN AEPNINARTS WPNSEKHVDQ EDAIEAYHGV CQTNSKTEDW
GYLNEDGELG LAYQGLKQVA RLLEAQLQAQ SLEHEAAVEQ LQAQVEALKE ELDRQQQTFS
QTLLLSPEAQ VEFGVQQEMS RLTNENLDFK ELVEKLEKNE RKLKKQLKIY MKKVQDLEAA
QALAQSDRRR HELTRQVTVQ RKEKDFQGML EYHKEDEAAL IRNLVTDLKP QTLLGTVPCL
PAYILYMCIR HADYTNDDLK VHSLLTSTIN GIKKVLKKHN DDFEMTTFWL SNTCRLLHCL
KQYSGDEGFM TQNTAKQNEH CLKNFDLTEY RQVLSDLSIQ IYQQLIKIAE GLLQPMIVSA
MLENESIQGL SGVKPTGYRK RSSSMADGDN AYCLEAVIRQ MNSFHTVMCD QGLDPEIIQQ
VFKQLFYMIS AVTLNNLLLR KDACSWSTGM QLRYNISQLE EWLRGRNLHQ SGAVQTMEPL
IQAAQLLQLK KKTQEDAEAI CSLCTALSTQ QIVKILNLYT PLNEFEERVT VAFIRTIQAQ
LQERNDPQQL LLDFKHMFPV LFPFNPSSLT MDSIHIPACL NLEFLNEV
//
