ID G1U0G3_RABIT Unreviewed; 758 AA.
AC G1U0G3;
DT 19-OCT-2011, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 62.
DE RecName: Full=N-terminal Ras-GEF domain-containing protein {ECO:0000259|PROSITE:PS50212};
OS Oryctolagus cuniculus (Rabbit).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus.
OX NCBI_TaxID=9986 {ECO:0000313|Ensembl:ENSOCUP00000022843.3, ECO:0000313|Proteomes:UP000001811};
RN [1] {ECO:0000313|Ensembl:ENSOCUP00000022843.3, ECO:0000313|Proteomes:UP000001811}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Thorbecke {ECO:0000313|Proteomes:UP000001811};
RX PubMed=21993624; DOI=10.1038/nature10530;
RA Lindblad-Toh K., Garber M., Zuk O., Lin M.F., Parker B.J., Washietl S.,
RA Kheradpour P., Ernst J., Jordan G., Mauceli E., Ward L.D., Lowe C.B.,
RA Holloway A.K., Clamp M., Gnerre S., Alfoldi J., Beal K., Chang J.,
RA Clawson H., Cuff J., Di Palma F., Fitzgerald S., Flicek P., Guttman M.,
RA Hubisz M.J., Jaffe D.B., Jungreis I., Kent W.J., Kostka D., Lara M.,
RA Martins A.L., Massingham T., Moltke I., Raney B.J., Rasmussen M.D.,
RA Robinson J., Stark A., Vilella A.J., Wen J., Xie X., Zody M.C., Baldwin J.,
RA Bloom T., Chin C.W., Heiman D., Nicol R., Nusbaum C., Young S.,
RA Wilkinson J., Worley K.C., Kovar C.L., Muzny D.M., Gibbs R.A., Cree A.,
RA Dihn H.H., Fowler G., Jhangiani S., Joshi V., Lee S., Lewis L.R.,
RA Nazareth L.V., Okwuonu G., Santibanez J., Warren W.C., Mardis E.R.,
RA Weinstock G.M., Wilson R.K., Delehaunty K., Dooling D., Fronik C.,
RA Fulton L., Fulton B., Graves T., Minx P., Sodergren E., Birney E.,
RA Margulies E.H., Herrero J., Green E.D., Haussler D., Siepel A., Goldman N.,
RA Pollard K.S., Pedersen J.S., Lander E.S., Kellis M.;
RT "A high-resolution map of human evolutionary constraint using 29 mammals.";
RL Nature 478:476-482(2011).
RN [2] {ECO:0000313|Ensembl:ENSOCUP00000022843.3}
RP IDENTIFICATION.
RC STRAIN=Thorbecke {ECO:0000313|Ensembl:ENSOCUP00000022843.3};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; G1U0G3; -.
DR Ensembl; ENSOCUT00000029108.3; ENSOCUP00000022843.3; ENSOCUG00000026879.3.
DR eggNOG; KOG3629; Eukaryota.
DR GeneTree; ENSGT00940000153181; -.
DR HOGENOM; CLU_389298_0_0_1; -.
DR TreeFam; TF339069; -.
DR Proteomes; UP000001811; Unplaced.
DR Bgee; ENSOCUG00000026879; Expressed in testis.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR CDD; cd06224; REM; 3.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 3.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR PANTHER; PTHR46793:SF1; 1700018F24RIK PROTEIN-RELATED; 1.
DR PANTHER; PTHR46793; 1700018F24RIK PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF00618; RasGEF_N; 3.
DR SMART; SM00229; RasGEFN; 3.
DR SUPFAM; SSF48366; Ras GEF; 3.
DR PROSITE; PS50212; RASGEF_NTER; 3.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00135};
KW Reference proteome {ECO:0000313|Proteomes:UP000001811}.
FT DOMAIN 120..241
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 311..432
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 502..623
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT REGION 40..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 244..276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 286..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 434..465
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..496
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 625..647
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 689..734
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 40..60
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 758 AA; 83357 MW; 469884A83128C2D0 CRC64;
MFSCCLPTSQ GPGRGQPQAA DILQSYRHWV SPRPQQLWQF SQREAKNDSD FATSQDDTSG
VGAMVAGRLE GEPSPKAADS ASLEPDPAEA AAAEMGPGSM LESEEPAAQA PVLSLLAASS
VGTLDTAVVE KLVTQLLPAQ QTGDPFIVPS FLCNYRRFTT TQQVLNLLFH RYAYFQPHCE
EDDRTKDALC SLLGTWLDRY PEHFCQPQDL TCLHQLLAYV QLHMPFSDLA LRAQRLLTQL
EDPEPKEAEA EPKDLAPTTA AAPQPESAEP SPPRAVHLSA AEALEAPDGP SAAPHQEQDV
GTVPSLSAAS RVGTLDTGMV EKLVNQLVPA QQRGDPFFIP TFLNIYQRFA TTQQVLHLLF
QRYASFQPHC EEDDRTKHAL CSLLGTWLDR YPEHFCQPQD LTCLHQLLAY VQLHMPFSDL
ALRAQRNLTQ LEDPEPKEAE AEPKDLVPTT AAAPQPESAE PSLPRAVHLS AAEALEAPEG
PSAGPHQEQD VGTVPSLSAA SRVGTLDTGM VEKLVNQLVP AQQRGDPFFI PTFLNIYQRF
ATTQQVLHLL FQRYASFQPH CEEDDRTKHA LCSFLGTWRD RYPEHFCQPQ DLASLNQLLA
YVQLQMPSSD LARRAQLLLM QLEDTEPQEA EAEAEPEAPA PGGDLEAPLP AAAALLGSDL
VATPASAPQP EPPEACLSLA TVPAVEALEP PASPEAKPEP EHPQPWFTKR RWPWGRRRGQ
RTISNQDRPH RHSPSWVRTL LSCFPIHSSG PRSGPSHE
//
